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MedKoo Cat#: 146148 | Name: Florbetaben

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Florbetaben is a radiolabeled compound used in positron emission tomography (PET) imaging, specifically for the detection of amyloid plaques in the brain. It is primarily applied in the diagnosis of Alzheimer's disease and other neurodegenerative disorders, as amyloid plaque accumulation is a key hallmark of these conditions. Florbetaben binds specifically to amyloid beta plaques, allowing for clear imaging and aiding in the assessment of disease progression. This imaging tool helps clinicians differentiate Alzheimer's disease from other forms of dementia and assess the effectiveness of treatments.

Chemical Structure

Florbetaben
Florbetaben
CAS#902142-97-6

Theoretical Analysis

MedKoo Cat#: 146148

Name: Florbetaben

CAS#: 902142-97-6

Chemical Formula: C21H26FNO3

Exact Mass: 359.1897

Molecular Weight: 359.44

Elemental Analysis: C, 70.17; H, 7.29; F, 5.29; N, 3.90; O, 13.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Florbetaben;
IUPAC/Chemical Name
(E)-4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)styryl)-N-methylaniline
InChi Key
NCWZOASIUQVOFA-NSCUHMNNSA-N
InChi Code
1S/C21H26FNO3/c1-23-20-8-4-18(5-9-20)2-3-19-6-10-21(11-7-19)26-17-16-25-15-14-24-13-12-22/h2-11,23H,12-17H2,1H3/b3-2+
SMILES Code
CNC1=CC=C(\C=C\C2=CC=C(OCCOCCOCCF)C=C2)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 359.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Florbetaben F 18. 2020 Aug 17. PMID: 29999993. 2: Sabri O, Seibyl J, Rowe C, Barthel H. Beta-amyloid imaging with florbetaben. Clin Transl Imaging. 2015;3(1):13-26. doi: 10.1007/s40336-015-0102-6. Epub 2015 Feb 12. PMID: 25741488; PMCID: PMC4339690. 3: Barthel H, Sabri O. Florbetaben to trace amyloid-β in the Alzheimer brain by means of PET. J Alzheimers Dis. 2011;26 Suppl 3:117-21. doi: 10.3233/JAD-2011-0068. PMID: 21971456. 4: Syed YY, Deeks E. [(18)F]Florbetaben: a review in β-amyloid PET imaging in cognitive impairment. CNS Drugs. 2015 Jul;29(7):605-13. doi: 10.1007/s40263-015-0258-7. PMID: 26175116. 5: Richards D, Sabbagh MN. Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain. Neurol Ther. 2014 Nov 27;3(2):79-88. doi: 10.1007/s40120-014-0022-9. PMID: 26000224; PMCID: PMC4386430. 6: Rezai AR, D'Haese PF, Finomore V, Carpenter J, Ranjan M, Wilhelmsen K, Mehta RI, Wang P, Najib U, Vieira Ligo Teixeira C, Arsiwala T, Tarabishy A, Tirumalai P, Claassen DO, Hodder S, Haut MW. Ultrasound Blood-Brain Barrier Opening and Aducanumab in Alzheimer's Disease. N Engl J Med. 2024 Jan 4;390(1):55-62. doi: 10.1056/NEJMoa2308719. PMID: 38169490. 7: Cassano Cassano R, Genovesi D, Vergaro G, Giorgetti A, Aimo A, Del Giudice ML, Galimberti S, Emdin M, Buda G. [18F]-florbetaben PET/CT is sensitive for cardiac AL amyloidosis. Eur J Clin Invest. 2024 Oct;54(10):e14270. doi: 10.1111/eci.14270. Epub 2024 Jul 17. PMID: 39021058. 8: Schindler TH, Sharma V, Imperiale A. 18F-Florbetaben and PET/CT Holds Promise for the Identification and Differentiation Among Cardiac Amyloidosis Entities. JACC Cardiovasc Imaging. 2021 Jan;14(1):256-258. doi: 10.1016/j.jcmg.2020.06.017. Epub 2020 Aug 5. PMID: 32771579. 9: Chiaravalloti A, Danieli R, Lacanfora A, Palumbo B, Caltagirone C, Schillaci O. Usefulness of 18F Florbetaben in Diagnosis of Alzheimer's Disease and Other Types of Dementia. Curr Alzheimer Res. 2017;14(2):154-160. doi: 10.2174/1567205013666160620114309. PMID: 27334940. 10: Johns E, Vossler HA, Young CB, Carlson ML, Winer JR, Younes K, Park J, Rathmann-Bloch J, Smith V, Harrison TM, Landau S, Henderson V, Wagner A, Sha SJ, Zeineh M, Zaharchuk G, Poston KL, Davidzon GA, Mormino EC. Florbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation. Alzheimers Dement. 2024 Aug;20(8):5299-5310. doi: 10.1002/alz.13893. Epub 2024 Jul 4. PMID: 38962867; PMCID: PMC11350032. 11: Martínez G, Vernooij RW, Fuentes Padilla P, Zamora J, Flicker L, Bonfill Cosp X. 18F PET with florbetaben for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2017 Nov 22;11(11):CD012883. doi: 10.1002/14651858.CD012883. PMID: 29164600; PMCID: PMC6485979. 12: Shokri-Kojori E, Wang GJ, Wiers CE, Demiral SB, Guo M, Kim SW, Lindgren E, Ramirez V, Zehra A, Freeman C, Miller G, Manza P, Srivastava T, De Santi S, Tomasi D, Benveniste H, Volkow ND. β-Amyloid accumulation in the human brain after one night of sleep deprivation. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4483-4488. doi: 10.1073/pnas.1721694115. Epub 2018 Apr 9. PMID: 29632177; PMCID: PMC5924922. 13: Stenzel J, Rühlmann C, Lindner T, Polei S, Teipel S, Kurth J, Rominger A, Krause BJ, Vollmar B, Kuhla A. [18F]-florbetaben PET/CT Imaging in the Alzheimer's Disease Mouse Model APPswe/PS1dE9. Curr Alzheimer Res. 2019;16(1):49-55. doi: 10.2174/1567205015666181022095904. PMID: 30345916. 14: Holy EN, Li E, Bhattarai A, Fletcher E, Alfaro ER, Harvey DJ, Spencer BA, Cherry SR, DeCarli CS, Fan AP. Non-invasive quantification of 18F-florbetaben with total-body EXPLORER PET. Res Sq [Preprint]. 2023 Dec 27:rs.3.rs-3764930. doi: 10.21203/rs.3.rs-3764930/v1. Update in: EJNMMI Res. 2024 Apr 16;14(1):39. doi: 10.1186/s13550-024-01104-7. PMID: 38234716; PMCID: PMC10793501. 15: Genovesi D, Vergaro G, Giorgetti A, Marzullo P, Scipioni M, Santarelli MF, Pucci A, Buda G, Volpi E, Emdin M. [18F]-Florbetaben PET/CT for Differential Diagnosis Among Cardiac Immunoglobulin Light Chain, Transthyretin Amyloidosis, and Mimicking Conditions. JACC Cardiovasc Imaging. 2021 Jan;14(1):246-255. doi: 10.1016/j.jcmg.2020.05.031. Epub 2020 Aug 5. PMID: 32771577. 16: Rudolphi-Solero T, Triviño Ibáñez EM, Aroui T, Navidad RH, Gómez-Río M. Dual-Phase 18F-Florbetaben PET/CT: Unsuspected Thalamic Infarction Mimicking Alzheimer Disease. Clin Nucl Med. 2022 Apr 1;47(4):333-335. doi: 10.1097/RLU.0000000000003955. PMID: 34739400. 17: Jovalekic A, Bullich S, Roé-Vellvé N, Kolinger GD, Howard LR, Elsholz F, Lagos-Quintana M, Blanco-Rodriguez B, Pérez-Martínez E, Gismondi R, Perrotin A, Chapleau M, Keegan R, Mueller A, Stephens AW, Koglin N. Experiences from Clinical Research and Routine Use of Florbetaben Amyloid PET-A Decade of Post- Authorization Insights. Pharmaceuticals (Basel). 2024 Dec 7;17(12):1648. doi: 10.3390/ph17121648. PMID: 39770490; PMCID: PMC11728731. 18: D'Estanque E, Chambert B, Moranne O, Kotzki PO, Boudousq V. 18F-Florbetaben: A New Tool for Amyloidosis Staging? Clin Nucl Med. 2017 Jan;42(1):50-53. doi: 10.1097/RLU.0000000000001434. PMID: 27801739. 19: Holy EN, Li E, Bhattarai A, Fletcher E, Alfaro ER, Harvey DJ, Spencer BA, Cherry SR, DeCarli CS, Fan AP. Non-invasive quantification of 18F-florbetaben with total-body EXPLORER PET. EJNMMI Res. 2024 Apr 16;14(1):39. doi: 10.1186/s13550-024-01104-7. PMID: 38625413; PMCID: PMC11021392. 20: Papathanasiou M, Carpinteiro A, Hagenacker T, Herrmann K, Rassaf T, Rischpler C, Luedike P. 18F-florbetaben positron emission tomography detects cardiac involvement in systemic AA amyloidosis. Eur J Nucl Med Mol Imaging. 2020 Dec;47(13):3186-3187. doi: 10.1007/s00259-020-04861-4. Epub 2020 May 20. Erratum in: Eur J Nucl Med Mol Imaging. 2020 Dec;47(13):3196. doi: 10.1007/s00259-020-04907-7. PMID: 32435877; PMCID: PMC7680313.