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MedKoo Cat#: 461234 | Name: Reserpiline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Reserpiline is a a hypotensive extract of Rauwolfia vomitoria.

Chemical Structure

Reserpiline
Reserpiline
CAS#131-02-2

Theoretical Analysis

MedKoo Cat#: 461234

Name: Reserpiline

CAS#: 131-02-2

Chemical Formula: C23H28N2O5

Exact Mass: 412.1998

Molecular Weight: 412.48

Elemental Analysis: C, 66.97; H, 6.84; N, 6.79; O, 19.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Reserpiline; Elliptamine;
IUPAC/Chemical Name
methyl (4S,4aS,13bR,14aS)-10,11-dimethoxy-4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylate
InChi Key
FGWJRZQNNZVCHR-BCRCDCHUSA-N
InChi Code
InChI=1S/C23H28N2O5/c1-12-16-10-25-6-5-13-15-8-20(27-2)21(28-3)9-18(15)24-22(13)19(25)7-14(16)17(11-30-12)23(26)29-4/h8-9,11-12,14,16,19,24H,5-7,10H2,1-4H3/t12-,14-,16-,19+/m0/s1
SMILES Code
[H][C@@]12C(NC3=C4C=C(OC)C(OC)=C3)=C4CCN1C[C@]5([C@H](C)OC=C(C(OC)=O)[C@]5(C2)[H])[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 412.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: LA BARRE J, LIEBER CS. [Effects of reserpiline on gastric hypersecretion and hyperacidity after insulin administration]. C R Seances Soc Biol Fil. 1958;152(4):683-5. English, French. PubMed PMID: 13597381. 2: LA BARRE J, HANS MJ, DESMAREZ JJ. [Reserpiline, an hypotensive and non-tranquilizing alkaloid]. C R Seances Soc Biol Fil. 1958;152(3):533-4. French. PubMed PMID: 13597329. 3: HARIGA M. [Preliminary trial of therapeutic use of reserpiline, a hypotensive extract of Rauwolfia vomitoria]. Brux Med. 1959 Mar 29;39(13):451-5. French. PubMed PMID: 13638673. 4: Pauchant M, Bernard JM. [Treatment of arterial hypertension with an association of reserpiline, theophylline and papaverine]. Lille Med. 1971;17:Suppl 3:545-50. French. PubMed PMID: 5153014. 5: Tang HC, Chen CY. Drug design of cyclin-dependent kinase 2 inhibitor for melanoma from traditional Chinese medicine. Biomed Res Int. 2014;2014:798742. doi: 10.1155/2014/798742. Epub 2014 Jun 19. PubMed PMID: 25045703; PubMed Central PMCID: PMC4090515. 6: Balón-Almeida M, Muñoz-Perez MA, Hidalgo-Toledo J, Sánchez-González M. Fluorescence characteristics of Rauwolfia alkaloids in highly concentrated sulphuric acid solutions. Fluorimetric determination of reserpiline. J Pharm Biomed Anal. 1986;4(4):505-9. PubMed PMID: 16867587. 7: GOUTAREL R, GUT M, PARELLO J. [A new alkaloid, isolated from Rauwolfia vomitoria Afz., rauvanine, isomer of reserpiline]. C R Hebd Seances Acad Sci. 1961 Nov 27;253:2589-91. French. PubMed PMID: 13900856. 8: LA BARRE J, GILLO L. [Chemical characteristics of reserpiline and absence of gastric ulcerogenic properties]. C R Seances Soc Biol Fil. 1958;152(3):530-1. French. PubMed PMID: 13597327. 9: LA BARRE J. [The pharmacodynamic properties of reserpiline]. Bull Acad R Med Belg. 1958;23(3-4):240-57. French. PubMed PMID: 13596689. 10: Vieira MN, Leitão SG, Porto PC, Oliveira DR, Pinto SC, Braz-Filho R, Leitão GG. Application of pH-zone-refining countercurrent chromatography for the separation of indole alkaloids from Aspidosperma rigidum Rusby. J Chromatogr A. 2013 Dec 6;1319:166-71. doi: 10.1016/j.chroma.2013.10.044. Epub 2013 Oct 22. PubMed PMID: 24192149. 11: PLISNIER H. [Apropos of the effects of reserpine, reserpiline, and raumitorine on bronchial secretion]. C R Seances Soc Biol Fil. 1960;154:457-8. French. PubMed PMID: 14433499. 12: Maurya A, Gupta S, Srivastava SK. Large-scale separation of antipsychotic alkaloids from Rauwolfia tetraphylla L. by pH-zone-refining fast centrifugal partition chromatography. J Sep Sci. 2013 Jan;36(2):407-13. doi: 10.1002/jssc.201200273. Epub 2012 Nov 29. PubMed PMID: 23335460. 13: LA BARRE J, LIEBER CS, CASTIAU J. [Effect of reserpiline on gastric secretion and motility]. C R Seances Soc Biol Fil. 1958;152(3):532-3. French. PubMed PMID: 13597328. 14: Dwivedi GR, Gupta S, Maurya A, Tripathi S, Sharma A, Darokar MP, Srivastava SK. Synergy Potential of Indole Alkaloids and Its Derivative against Drug-resistant Escherichia coli. Chem Biol Drug Des. 2015 Dec;86(6):1471-81. doi: 10.1111/cbdd.12613. Epub 2015 Aug 21. PubMed PMID: 26132412. 15: Akinloye BA, Court WE. The alkaloids of Rauwolfia volkensii. J Ethnopharmacol. 1981 Jul;4(1):99-109. PubMed PMID: 7253681. 16: Kouamo K, Creche J, Chénieux JC, Rideau M, Viel C. Alkaloid Production by Ochrosia elliptica Cell Suspension Cultures. J Plant Physiol. 1985 Mar;118(3):277-83. doi: 10.1016/S0176-1617(85)80229-7. Epub 2012 Jan 2. PubMed PMID: 23196012. 17: Iwu MM, Court WE. Stem bark alkaloids of Rauwolfia vomitoria. Planta Med. 1982 Jun;45(2):105-11. PubMed PMID: 17396795. 18: Gupta S, Khanna VK, Maurya A, Bawankule DU, Shukla RK, Pal A, Srivastava SK. Bioactivity guided isolation of antipsychotic constituents from the leaves of Rauwolfia tetraphylla L. Fitoterapia. 2012 Sep;83(6):1092-9. doi: 10.1016/j.fitote.2012.04.029. Epub 2012 May 3. PubMed PMID: 22579842. 19: Gupta S, Shanker K, Srivastava SK. HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: a study of organic/green solvent and continuous/pulse sonication. J Pharm Biomed Anal. 2012 Jul;66:33-9. doi: 10.1016/j.jpba.2012.02.018. Epub 2012 Mar 8. PubMed PMID: 22464556.