MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 524548 | Name: Candoxatrilat

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Candoxatrilat, also known as U 73967 and UK69578, is an active neutral endopeptidase inhibitor that reduces degradation of atrial natriuretic peptide. Candoxatrilat reduces the clearance of atrial natriuretic factor in both intact and nephrectomized rats: evidence for an extrarenal site of action.

Chemical Structure

Candoxatrilat
Candoxatrilat
CAS#123122-54-3

Theoretical Analysis

MedKoo Cat#: 524548

Name: Candoxatrilat

CAS#: 123122-54-3

Chemical Formula: C20H33NO7

Exact Mass: 399.2257

Molecular Weight: 399.48

Elemental Analysis: C, 60.13; H, 8.33; N, 3.51; O, 28.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
U 73967; U-73967; U73967; UK69578; UK-69578; UK 69578; Candoxatrilate; Candoxatrilat.
IUPAC/Chemical Name
(1R,4s)-4-(1-((S)-2-carboxy-3-(2-methoxyethoxy)propyl)cyclopentanecarboxamido)cyclohexanecarboxylic acid
InChi Key
ACZWIDANLCXHBM-HRCADAONSA-N
InChi Code
InChI=1S/C20H33NO7/c1-27-10-11-28-13-15(18(24)25)12-20(8-2-3-9-20)19(26)21-16-6-4-14(5-7-16)17(22)23/h14-16H,2-13H2,1H3,(H,21,26)(H,22,23)(H,24,25)/t14-,15-,16+/m0/s1
SMILES Code
COCCOC[C@@H](C(=O)O)CC1(CCCC1)C(=O)N[C@H]2CC[C@H](CC2)C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 399.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kaye B, Brearley CJ, Cussans NJ, Herron M, Humphrey MJ, Mollatt AR. Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril. Xenobiotica. 1997 Oct;27(10):1091-102. PubMed PMID: 9364744. 2: Barclay PL, Bennett JA, Greengrass PM, Griffin A, Samuels GM, Shepperson NB. The pharmacokinetics of 125I-atrial natriuretic factor in anaesthetized rats. Effects of neutral endopeptidase inhibition with candoxatrilat and of ANF-C receptor blockade. Biochem Pharmacol. 1992 Sep 25;44(6):1013-22. PubMed PMID: 1417928. 3: Barclay PL, Bennett JA, Samuels GM, Shepperson NB. The atriopeptidase inhibitor (+/-) candoxatrilat reduces the clearance of atrial natriuretic factor in both intact and nephrectomized rats: evidence for an extrarenal site of action. Biochem Pharmacol. 1991 Mar 1;41(5):841-4. PubMed PMID: 1847819.