MedKoo Cat#: 461219 | Name: Rentiapril

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rentiapril is an angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity.

Chemical Structure

Rentiapril
Rentiapril
CAS#72679-47-1

Theoretical Analysis

MedKoo Cat#: 461219

Name: Rentiapril

CAS#: 72679-47-1

Chemical Formula: C13H15NO4S2

Exact Mass: 313.0442

Molecular Weight: 313.38

Elemental Analysis: C, 49.82; H, 4.82; N, 4.47; O, 20.42; S, 20.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Rentiapril;
IUPAC/Chemical Name
2-(2-hydroxyphenyl)-3-(3-mercaptopropanoyl)thiazolidine-4-carboxylic acid
InChi Key
BSHDUMDXSRLRBI-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H15NO4S2/c15-10-4-2-1-3-8(10)12-14(11(16)5-6-19)9(7-20-12)13(17)18/h1-4,9,12,15,19H,5-7H2,(H,17,18)
SMILES Code
O=C(C1N(C(CCS)=O)C(C2=CC=CC=C2O)SC1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 313.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takase K, Ikuse T, Aono H, Okahara A. Toxicity study of the angiotensin converting enzyme inhibitor rentiapril in rats. Arzneimittelforschung. 1995 Jan;45(1):15-8. PubMed PMID: 7893262. 2: Ideishi M, Sasaguri M, Ikeda M, Arakawa K. Effects of the angiotensin converting enzyme inhibitors captopril, rentiapril, and alacepril in patients with essential and renovascular hypertension. Clin Ther. 1989 Jul-Aug;11(4):441-51. PubMed PMID: 2550133. 3: Cozens DD, Barton SJ, Clark R, Hughes EW, Offer JM, Yamamoto Y. Reproductive toxicity studies of rentiapril. Arzneimittelforschung. 1987 Feb;37(2):164-9. PubMed PMID: 3034299. 4: Yamauchi H, Nishimura K, Nakata K, Suda H, Iso T, Shimizu M, Hiramatsu Y. General pharmacological properties of the potent angiotensin converting enzyme inhibitor rentiapril. Arzneimittelforschung. 1987 Feb;37(2):157-64. PubMed PMID: 3034298. 5: Takata Y, Di Nicolantonio R, Mendelsohn FA, Hutchinson JS, Doyle AE. A comparison of the activity of the angiotensin converting enzyme inhibitors SQ 14 225, SA 446, and MK 421. Clin Exp Pharmacol Physiol. 1983 Mar-Apr;10(2):131-45. PubMed PMID: 6307563. 6: Kuno N, Mizutani S, Ohno Y, Goto K, Itakura A, Kondo I, Kurauchi O, Kikkawa F, Tomoda Y. Possible involvement of placental proteases in bradykinin (BK) degradation. Reprod Fertil Dev. 1997;9(6):633-9. PubMed PMID: 9551668. 7: Hooper NM, Hryszko J, Oppong SY, Turner AJ. Inhibition by converting enzyme inhibitors of pig kidney aminopeptidase P. Hypertension. 1992 Mar;19(3):281-5. PubMed PMID: 1312513. 8: Shimada K, Tanaka M, Nambara T, Imai Y. Determination of a new antihypertensive agent (2R,4R)-2-(2-hydroxyphenyl)-3-(3-mercaptopropionyl)-4- thiazolidinecarboxylic acid in blood by high-performance liquid chromatography with electrochemical detection. J Pharm Sci. 1984 Jan;73(1):119-21. PubMed PMID: 6694067. 9: Mizuno K, Nakamaru M, Higashimori K, Inagami T. Local generation and release of angiotensin II in peripheral vascular tissue. Hypertension. 1988 Mar;11(3):223-9. PubMed PMID: 3280482. 10: Nishimura K, Miyazaki M, Okunishi H, Toda N. Hypotensive effect of SA446, an angiotensin converting enzyme inhibitor, in 2-kidney, 1-clip renal hypertensive and normotensive dogs. Jpn J Pharmacol. 1987 Apr;43(4):379-87. PubMed PMID: 3039218. 11: Okunishi H, Miyazaki M, Toda N. Evidence for a putatively new angiotensin II-generating enzyme in the vascular wall. J Hypertens. 1984 Jun;2(3):277-84. PubMed PMID: 6099388. 12: Dinicolantonio R, Mendelsohn FA, Takata Y, Hutchinson JS, Doyle AE. Mechanisms of converting enzyme inhibition: studies in experimental animals. Neth J Med. 1984;27(4):153-60. PubMed PMID: 6330589. 13: Miyazaki M, Okunishi H, Okamura T, Toda N. Elevated vascular angiotensin converting enzyme in chronic two-kidney, one clip hypertension in the dog. J Hypertens. 1987 Apr;5(2):155-60. PubMed PMID: 3038993. 14: Mendelsohn FA, Csicsmann J, Hutchinson JS. Complex competitive and non-competitive inhibition of rat lung angiotensin-converting enzyme by inhibitors containing thiol groups: captopril and SA 446. Clin Sci (Lond). 1981 Dec;61 Suppl 7:277s-280s. PubMed PMID: 6172236. 15: Iwatani T, Naitoh M, Takashina H, Nagamori S, Itoh Y, Iwao J. Determination of SA-446 in human whole blood and urine by electron capture-gas liquid chromatography. Chem Pharm Bull (Tokyo). 1982 Jun;30(6):2087-93. PubMed PMID: 6290091. 16: Abe K, Tajima J, Omata K, Tanno M, Tsunoda K, Kudo K, Onoda Y, Kohzuki M, Sasaki S, Takeuchi K, et al. Effects of three different kininase II inhibitors on blood pressure and renal vasoactive substances in essential hypertensives. Adv Exp Med Biol. 1986;198 Pt B:269-77. PubMed PMID: 3028076. 17: Hooper NM, Hesp RJ, Tieku S. Metabolism of aspartame by human and pig intestinal microvillar peptidases. Biochem J. 1994 Mar 15;298 Pt 3:635-9. PubMed PMID: 8141778; PubMed Central PMCID: PMC1137907. 18: Sugawara M, Hashimoto A, Toda T, Takahashi M, Kobayashi M, Iseki K, Miyazaki K. Changes in the permeation rate of organic anions through the intestinal brush-border membrane with membrane surface potential. Biochim Biophys Acta. 1994 Feb 23;1190(1):85-90. PubMed PMID: 8110822. 19: Kondo K, Kida O, Kodama K, Higa T, Someya N, Morotomi Y, Tanaka K. Comparison of the acute effects of three structurally different converting enzyme inhibitors (captopril, SA-446 and MK-421) on blood pressure, the renin-angiotensin system and the kallikrein-kinin system. Nihon Jinzo Gakkai Shi. 1985 Mar;27(3):337-42. PubMed PMID: 2991635. 20: Saruta T, Suzuki H, Okuno T, Kondo K. Effects of angiotensin-converting enzyme inhibitors on the vascular response to norepinephrine. Am J Cardiol. 1982 Apr 21;49(6):1535-6. PubMed PMID: 6176110.