FR-295389 | FR-295389 Free Base | CAS#1019207-72-7 | 1019207-72-6 | cephalosporin

MedKoo Cat#: 525135 | Name: FR-295389

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR-295389 is a new cephalosporin. FR-295389 shows effective in vitro antibacterial activity against metallo-beta-lactamase (MBL)-producers. The MIC values of FR295389 at which 50% and 90% of 21 clinical isolates of IMP-type MBL-producing Pseudomonas aeruginosa were inhibited were 8.0 and 32 mug/ml, respectively.

Chemical Structure

FR-295389

CAS#1019207-72-7(FR-295389)

Theoretical Analysis

MedKoo Cat#: 525135

Name: FR-295389

CAS#: 1019207-72-7(FR-295389)

Chemical Formula: C25H35N13O11S3

Exact Mass:

Molecular Weight: 789.82

Elemental Analysis: C, 38.02; H, 4.47; N, 23.05; O, 22.28; S, 12.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1019207-72-7(FR-295389); 1019207-71-6 (FR-295389 Free Base)

Synonym

FR-295389; FR295389; FR 295389; FR-295389 Free Base.

IUPAC/Chemical Name

(6R,7R)-7-((Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((7-(1-(3-aminopropyl)guanidino)-2H-imidazo[1,2-b]pyrazol-5(3H)-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid compound with sulfuric acid (1:1)

InChi Key

SRULPQKDNUEKQM-ZMNNRNPHSA-N

InChi Code

InChI=1S/C25H33N13O7S2.H2O4S/c1-25(2,22(43)44)45-33-13(16-32-24(29)47-34-16)18(39)31-14-19(40)38-15(21(41)42)11(10-46-20(14)38)8-35-9-12(17-30-5-7-37(17)35)36(23(27)28)6-3-4-26;1-5(2,3)4/h9,14,20H,3-8,10,26H2,1-2H3,(H3,27,28)(H,31,39)(H,41,42)(H,43,44)(H2,29,32,34);(H2,1,2,3,4)/b33-13-;/t14-,20-;/m1./s1

SMILES Code

CC(C)(C(=O)O)O/N=C(/c1nc(sn1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)CN4C=C(C5=NCCN54)N(CCCN)C(=N)N)C(=O)O.OS(=O)(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 789.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Takeda S, Ikeda F, Hatano K. In vitro antibacterial activity of a new cephalosporin, FR295389, against IMP-type metallo-beta-lactamase-producers. J Antibiot (Tokyo). 2008 Jan;61(1):36-9. doi: 10.1038/ja.2008.107. PubMed PMID: 18305358.