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MedKoo Cat#: 461218 | Name: Diatrizoate meglumine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diatrizoate meglumine is the meglumine salt form of diatrizoate, an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography.

Chemical Structure

Diatrizoate meglumine
CAS#131-49-7 (meglumine)

Theoretical Analysis

MedKoo Cat#: 461218

Name: Diatrizoate meglumine

CAS#: 131-49-7 (meglumine)

Chemical Formula: C18H26I3N3O9

Exact Mass: 808.8803

Molecular Weight: 809.13

Elemental Analysis: C, 26.72; H, 3.24; I, 47.05; N, 5.19; O, 17.80

Price and Availability

Size Price Availability Quantity
5g USD 300.00 2 Weeks
10g USD 450.00 2 Weeks
25g USD 850.00 2 Weeks
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Related CAS #
117-96-4 (free acid) 737-31-5 (sodium) 131-49-7 (meglumine) 50978-11-5 (Dihydrate)
Synonym
Diatrizoate meglumine; Meglumine diatrizoate; Meglumine amidotrizoate; Cardiografin; Hypaque; Reno; Renocal; Renografin; Renovist; Sinografin; Unipaque;
IUPAC/Chemical Name
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol 3,5-diacetamido-2,4,6-triiodobenzoate
InChi Key
MIKKOBKEXMRYFQ-WZTVWXICSA-N
InChi Code
InChI=1S/C11H9I3N2O4.C7H17NO5/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-2H3,(H,15,17)(H,16,18)(H,19,20);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
SMILES Code
O=C(O)C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 809.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Peterson CM, Lin M, Pilgram T, Heiken JP. Prospective randomized trial of iohexol 350 versus meglumine sodium diatrizoate as an oral contrast agent for abdominopelvic computed tomography. J Comput Assist Tomogr. 2011 Mar-Apr;35(2):202-5. doi: 10.1097/RCT.0b013e3182058e76. PubMed PMID: 21412090. 2: Hayman LA, Pagani JJ, Serur JR, Hinck VC. Impermeability of the blood-brain barrier to intravenous high-iodine-dose meglumine diatrizoate in the normal dog. AJNR Am J Neuroradiol. 1984 Jul-Aug;5(4):409-11. PubMed PMID: 6205572. 3: Shea JJ, Emmett JR, Harell M. Evaluation of diatrizoate meglumine (Hypaque) in treatment of sudden hearing loss. Laryngoscope. 1977 Nov;87(11):1809-14. PubMed PMID: 916773. 4: Jacobson ED, Eldon C, Fondacaro JD. Effects of a rapid injection into the canine superior mesenteric artery of diatrizoate meglumine and diatrizoate sodium (Renografin-76). Cardiovasc Intervent Radiol. 1980;3(3):159-62. PubMed PMID: 7407811. 5: Sam MC, Gutmann L. Spinal myoclonus following intrathecal administration of diatrizoate meglumine. J Neuroimaging. 1996 Oct;6(4):256-8. PubMed PMID: 8903083. 6: Agwu KK, Mgbor S, Ogbu SO, Okeji M. The effect of in-vivo intravenous administration of sodium meglumine diatrizoate on some haematological parameters. Niger J Med. 2007 Oct-Dec;16(4):360-3. PubMed PMID: 18080596. 7: Bernardino ME, Fishman EK, Jeffrey RB Jr, Brown PC. Comparison of iohexol 300 and diatrizoate meglumine 60 for body CT: image quality, adverse reactions, and aborted/repeated examinations. AJR Am J Roentgenol. 1992 Mar;158(3):665-7. PubMed PMID: 1739017. 8: Kido DK, Morris TW, Ekholm S, Plassche W, Erickson JL. Comparison of iohexol and meglumine-Na diatrizoate in cerebral angiography. Acta Radiol Suppl. 1983;366:142-6. PubMed PMID: 6591738. 9: Miller SH. Anaphylactoid reaction after oral administration of diatrizoate meglumine and diatrizoate sodium solution. AJR Am J Roentgenol. 1997 Apr;168(4):959-61. PubMed PMID: 9124149. 10: Belle MB, Leffa DD, Mazzorana D, De Andrade VM. Evaluation of the mutagenic effect of the iodinated contrast medium Urografina® 292 using the micronucleus test in mouse bone marrow cells. An Acad Bras Cienc. 2013 Apr-Jun;85(2):737-44. doi: 10.1590/S0001-37652013000200018. PubMed PMID: 23828339. 11: Dean PB. Extravascular distribution of intravascular meglumine diatrizoate: effect of concentration and dose. Ann Radiol (Paris). 1978 May-Jun;21(4-5):303-5. PubMed PMID: 718086. 12: Owman T. Comparison of the excretion of sodium and meglumine diatrizoate at urography with simulated compression: an experimental study in the rat. Acta Pharmacol Toxicol (Copenh). 1981 Jul;49(1):21-7. PubMed PMID: 7336961. 13: Schmidt BJ, Foley WD, Bohorfoush AG. Toxic epidermal necrolysis related to oral administration of diluted diatrizoate meglumine and diatrizoate sodium. AJR Am J Roentgenol. 1998 Nov;171(5):1215-6. PubMed PMID: 9798850. 14: Sackett JF, Bergsjordet B, Seeger JF, Kieffer SA. Digital subtraction angiography. Comparison of meglumine-Na diatrizoate with iohexol. Acta Radiol Suppl. 1983;366:81-4. PubMed PMID: 6382939. 15: Yaghmai V, Harapanhalli RS, Patel YD, Baker SR, Rao DV. Effects of diatrizoate and iopamidol on spermatogenesis. Invest Radiol. 1993 Dec;28(12):1160-4. PubMed PMID: 8307722. 16: Turpeinen U, Pomoell UM. Liquid chromatographic determination of meglumine diatrizoate in human plasma and urine. J Chromatogr. 1986 Apr 25;377:460-5. PubMed PMID: 3486875. 17: Schmidek HH, Moreira D, Harder DR. Diatrizoate meglumine-induced dilation of rat basilar artery: an in vitro study. Neurosurgery. 1983 Feb;12(2):137-41. PubMed PMID: 6835495. 18: Hilz MJ, Huk W, Schellmann B, Sörgel F, Druschky KF. Fatal complications after myelography with meglumine diatrizoate. Neuroradiology. 1990;32(1):70-3. PubMed PMID: 2333138. 19: Dean PB, Kormano M. Intra-arterial bolus of 125I labeled meglumine diatrizoate. Early extravascular distribution. Acta Radiol Diagn (Stockh). 1977 Jul;18(4):425-32. PubMed PMID: 920233. 20: Norby LH, DiBona GF. The renal vascular effects of meglumine diatrizoate. J Pharmacol Exp Ther. 1975 Jun;193(3):932-40. PubMed PMID: 1151740.