Ronnel | CAS#299-84-3 | pesticide

MedKoo Cat#: 461208 | Name: Ronnel

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ronnel is an organophosphate pesticide with growth-promoting properties. Ronnel is an organophosphate pesticide with growth-promoting properties. Ronnel was toxic to the development of heterozygous ATM8 flies.

Chemical Structure

Ronnel

CAS#299-84-3

Theoretical Analysis

MedKoo Cat#: 461208

Name: Ronnel

CAS#: 299-84-3

Chemical Formula: C8H8Cl3O3PS

Exact Mass: 319.8997

Molecular Weight: 321.53

Elemental Analysis: C, 29.88; H, 2.51; Cl, 33.08; O, 14.93; P, 9.63; S, 9.97

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 350.00	2 weeks

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Synonym

Ronnel; Dermafosu; Ectoral; Korlane; Nanchor; Fenchlorphos; Viozene; Trolene;

IUPAC/Chemical Name

O,O-dimethyl O-(2,4,5-trichlorophenyl) phosphorothioate

InChi Key

JHJOOSLFWRRSGU-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H8Cl3O3PS/c1-12-15(16,13-2)14-8-4-6(10)5(9)3-7(8)11/h3-4H,1-2H3

SMILES Code

S=P(OC)(OC1=CC(Cl)=C(Cl)C=C1Cl)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

Ronnel is an inhibitor of the enzyme acetylcholinesterase (AChE). Ronnel is able to cause mitochondrial dysfunction.

In vitro activity:

The data from this study suggest that decreased conversion of thyroxine (T4) to triiodothyronine (T3) by propylthiouracil (PTU) or ronnel may be responsible for the increased plasma concentrations of T4 and slightly decreased plasma concentrations of T3 reported in steers treated with levels of both PTU and ronnel that are associated with growth stimulation. Reference: J Anim Sci. 1985 Jul;61(1):197-202. https://pubmed.ncbi.nlm.nih.gov/2411706/

In vivo activity:

This study found that ronnel was toxic to the development of heterozygous ATM allele (ATM8) flies. Ronnel did not affect the innate immune response of ATM8 flies, and it increased the already high levels of DNA damage in brains of ATM8 flies. Ronnel’s effects were not harmful to the lifespan of rescued ATM8 flies. Reference: PLoS One. 2018 Jan 16;13(1):e0190821. https://pubmed.ncbi.nlm.nih.gov/29338042/

	Solvent	mg/mL	mM
Solubility
	DMSO	100.0	310.99

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 321.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Kahl S, Bitman J, Rumsey TS. In vitro studies of the effect of propylthiouracil and ronnel on thyroxine-5'-monodeiodinase activity in steers. J Anim Sci. 1985 Jul;61(1):197-202. doi: 10.2527/jas1985.611197x. PMID: 2411706. 2. Rimkus SA, Wassarman DA. A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant. PLoS One. 2018 Jan 16;13(1):e0190821. doi: 10.1371/journal.pone.0190821. PMID: 29338042; PMCID: PMC5770031.

In vitro protocol:

In vivo protocol:

1. Rimkus SA, Wassarman DA. A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant. PLoS One. 2018 Jan 16;13(1):e0190821. doi: 10.1371/journal.pone.0190821. PMID: 29338042; PMCID: PMC5770031.

1: Nalipay MJN, King RB, Cai Y. Autonomy is equally important across East and West: Testing the cross-cultural universality of self-determination theory. J Adolesc. 2020 Jan;78:67-72. doi: 10.1016/j.adolescence.2019.12.009. Epub 2019 Dec 14. PMID: 31846888. 2: King RB, Datu JAD. Grateful students are motivated, engaged, and successful in school: Cross-sectional, longitudinal, and experimental evidence. J Sch Psychol. 2018 Oct;70:105-122. doi: 10.1016/j.jsp.2018.08.001. Epub 2018 Sep 13. PMID: 30340699. 3: Sobjak TM, Romão S, Cazarolli LH, Sampaio SC, Remor MB, Guimarães ATB. Evaluation of the antioxidant system and neurotoxic effects observed in Rhamdia branneri (Teleostei: Heptapteridae) sampled from streams of the lower Iguazu River basin. Ecotoxicol Environ Saf. 2018 Jul 15;155:162-170. doi: 10.1016/j.ecoenv.2018.02.063. Epub 2018 Mar 6. PMID: 29522881. 4: Rimkus SA, Wassarman DA. A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant. PLoS One. 2018 Jan 16;13(1):e0190821. doi: 10.1371/journal.pone.0190821. PMID: 29338042; PMCID: PMC5770031. 5: King RB, Datu JA. Happy classes make happy students: Classmates' well-being predicts individual student well-being. J Sch Psychol. 2017 Dec;65:116-128. doi: 10.1016/j.jsp.2017.07.004. Epub 2017 Aug 29. PMID: 29145940. 6: King RB. Examining the dimensional structure and nomological network of achievement goals in the Philippines. J Adolesc. 2015 Oct;44:214-8. doi: 10.1016/j.adolescence.2015.07.019. Epub 2015 Aug 21. PMID: 26298675. 7: Kanno A, Kawakami T, Takahashi Y, Onodera S. Enhancement of anti- cholinesterase activity of aqueous samples by hypochlorite oxidation for monitoring traces of organophosphorus pesticides in water. J Toxicol Sci. 2012;37(2):389-400. doi: 10.2131/jts.37.389. PMID: 22467030. 8: Li X, Gan P, Peng R, Huang C, Yu H. Determination of 23 organophosphorous pesticides in surface water using SPME followed by GC-MS. J Chromatogr Sci. 2010 Mar;48(3):183-7. doi: 10.1093/chromsci/48.3.183. PMID: 20223083. 9: De Nino A, Santelli F, Servidio N, Sindona G, Tagarelli A. Identification and assay of organophosphates in organic oranges by gas chromatography with pulsed flame photometric detection and ion-trap mass spectrometry. J AOAC Int. 2003 Sep-Oct;86(5):1003-7. PMID: 14632404. 10: Ramesh A, Balasubramanian M. Kinetics and hydrolysis of fenamiphos, fipronil, and trifluralin in aqueous buffer solutions. J Agric Food Chem. 1999 Aug;47(8):3367-71. doi: 10.1021/jf980885m. PMID: 10552659. 11: Mansour M, Barcelò D, Albaigès J. Analytical methodology for screening organophosphorus pesticides in biota samples. Sci Total Environ. 1992 Aug 12;123-124:45-56. doi: 10.1016/0048-9697(92)90131-b. PMID: 1439741. 12: Goodspeed DP, Chestnut LI. Determining organohalides in animal fats using gel permeation chromatographic cleanup: repeatability study. J Assoc Off Anal Chem. 1991 Mar-Apr;74(2):388-94. PMID: 2050618. 13: Berge GN, Sterri SH, Søli NE. Cholinesterase activities in uterus of normal and fenchlorphos treated blue foxes (Alopex lagopus) during various reproductive states. Acta Vet Scand. 1988;29(1):117-23. doi: 10.1186/BF03548400. PMID: 2462338; PMCID: PMC8152545. 14: Ott MG, Olson RA, Cook RR, Bond GG. Cohort mortality study of chemical workers with potential exposure to the higher chlorinated dioxins. J Occup Med. 1987 May;29(5):422-9. PMID: 2439670. 15: Paris DF, Rogers JE. Kinetic concepts for measuring microbial rate constants: effects of nutrients on rate constants. Appl Environ Microbiol. 1986 Feb;51(2):221-5. doi: 10.1128/aem.51.2.221-225.1986. PMID: 16346980; PMCID: PMC238850. 16: Kahl S, Bitman J, Rumsey TS. In vitro studies of the effect of propylthiouracil and ronnel on thyroxine-5'-monodeiodinase activity in steers. J Anim Sci. 1985 Jul;61(1):197-202. doi: 10.2527/jas1985.611197x. PMID: 2411706. 17: Trankina ML, Beitz DC, Trenkle AH. Effects of in vitro ronnel on metabolic activity in subcutaneous adipose tissue and skeletal muscle from steers. J Anim Sci. 1985 Mar;60(3):652-8. doi: 10.2527/jas1985.603652x. PMID: 2580822. 18: Francis BM, Metcalf RL, Hansen LG. Toxicity of organophosphorus esters to laying hens after oral and dermal administration. J Environ Sci Health B. 1985 Feb;20(1):73-95. doi: 10.1080/03601238509372469. PMID: 3989223. 19: Segrestaa JM, Dahan R, Houlbert D, Caulin C, Ronnel A, Abella ML. Chronocinétique en état stationnaire d'une théophylline à libération prolongée [Chronokinetics in steady state of a sustained-release theophylline]. Therapie. 1984 Nov-Dec;39(6):633-7. French. PMID: 6531736. 20: Gretch FM, Rosen JD. Automated sample cleanup for pesticide multiresidue determination. I. Evaluation of solvent partitioning module. J Assoc Off Anal Chem. 1984 Jan-Feb;67(1):108-11. PMID: 6698917.