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MedKoo Cat#: 577903 | Name: Protriptyline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Protriptyline is a tricyclic antidepressant similar in action and side effects to Imipramine. It may produce excitation.

Chemical Structure

Protriptyline
Protriptyline
CAS#438-60-8

Theoretical Analysis

MedKoo Cat#: 577903

Name: Protriptyline

CAS#: 438-60-8

Chemical Formula: C19H21N

Exact Mass: 263.1674

Molecular Weight: 263.38

Elemental Analysis: C, 86.64; H, 8.04; N, 5.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Protriptyline
IUPAC/Chemical Name
5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-
InChi Key
BWPIARFWQZKAIA-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3
SMILES Code
CNCCCC1c2ccccc2C=Cc3ccccc13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 263.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chang HT, Chou CT, Yu CC, Tsai JY, Sun TK, Liang WZ, Lin KL, Tseng HW, Kuo CC, Chen FA, Kuo DH, Pan CC, Ho CM, Shieh P, Jan CR. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34. doi: 10.3109/10799893.2014.1000464. Epub 2015 Jun 22. PubMed PMID: 26096164. 2: Bansode SB, Jana AK, Batkulwar KB, Warkad SD, Joshi RS, Sengupta N, Kulkarni MJ. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9(8):e105196. doi: 10.1371/journal.pone.0105196. eCollection 2014. PubMed PMID: 25141174; PubMed Central PMCID: PMC4139341. 3: Jo SH, Hong HK, Chong SH, Choe H. Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel. Life Sci. 2008 Jan 30;82(5-6):331-40. doi: 10.1016/j.lfs.2007.12.004. Epub 2008 Jan 11. PubMed PMID: 18191158. 4: Hanzel DA, Proia NG, Hudgel DW. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest. 1991 Aug;100(2):416-21. PubMed PMID: 1864117.