Synonym
Chloracyzine; Chlorazicine; Chloroacizin; Chloroacizine; Chloroacyzin;
IUPAC/Chemical Name
10H-Phenothiazine, 2-chloro-10-(3-(diethylamino)-1-oxopropyl)- (9CI)
InChi Key
OTEKOJQFKOIXMU-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H4Cl6/c9-7(10,11)5-1-2-6(4-3-5)8(12,13)14/h1-4H
SMILES Code
ClC(C1=CC=C(C(Cl)(Cl)Cl)C=C1)(Cl)Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
312.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Saratikov AS, Dmitrienko VF. Effects of papaverine, chloracyzine, and bencyclane on local blood flow and oxygen tension in cat brain. Cor Vasa. 1975;17(2):125-32. PubMed PMID: 1157501.
3: Saratikov AS, Usov LA, Voloshina E, Sakharova SA. The effect of chloracyzine upon cerebral circulation and some indices of cerebral metabolism. Cor Vasa. 1969;11(4):279-86. PubMed PMID: 5373324.
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9: ERINA EV. [Chloracizine therapy of patients with coronary insufficiency]. Klin Med (Mosk). 1961 Jun;39:95-100. Russian. PubMed PMID: 13697164.
10: Thomson FJ, Mitchell R. Differential involvement of phospholipase A2 in phorbol ester-induced luteinizing hormone and growth hormone release from rat anterior pituitary tissue. Mol Cell Endocrinol. 1993 Sep;95(1-2):75-83. PubMed PMID: 8243810.
11: Robinson JJ, Watson F, Bucknall RC, Edwards SW. Stimulation of reactive oxidant production in neutrophils by soluble and insoluble immune complexes occurs via different receptors/signal transduction systems. FEMS Immunol Med Microbiol. 1994 Mar;8(3):249-57. PubMed PMID: 8004062.
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15: Roldan ER, Mollinedo F. Diacylglycerol stimulates the Ca2(+)-dependent phospholipase A2 of ram spermatozoa. Biochem Biophys Res Commun. 1991 Apr 15;176(1):294-300. PubMed PMID: 2018523.
16: Sichko AI, Godiatskiĭ VE. [Extraction of chloracizine thiocyanate complex of cobalt]. Farmatsiia. 1970 Nov-Dec;19(6):49-54. Russian. PubMed PMID: 5510379.
17: Korolenko CP, Volkov PP, Pantelejev VI. [Clinical and experimental observations with chloracizine]. Cesk Psychiatr. 1968 Oct;64(5):345-8. Czech. PubMed PMID: 5701273.
18: Vorontsov VV. [The mechanism of the diuretic action of chlorazicin]. Biull Eksp Biol Med. 1975 Nov;80(11):53-7. Russian. PubMed PMID: 1218263.
19: Tarasiewicz M, Puzanowska-Tarasiewicz H. Determination of phenothiazine derivatives. IV. Colorimetric determination of chloracizine by means of iodobismuthite. Acta Pol Pharm. 1972;29(1):26-35. PubMed PMID: 5055284.
20: Avakumov V, Müller D, Glöckner R, Klinger W. The influence of chloracizine (Ch) and ftoracizine (Ft) on hexobarbital sleeping time, ethylmorphine N-demethylation and cytochrome P450 and b5 concentration in rat liver. Biochem Pharmacol. 1978;27(17):2177-9. PubMed PMID: 728169.
