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MedKoo Cat#: 598288 | Name: Isosorbide dinitrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin. It induces vasodilation with IC50 values of 0.56 and 1.82 µM for isolated precontracted rabbit femoral vein and artery, respectively. Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model. It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range. Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.

Chemical Structure

Isosorbide dinitrate
Isosorbide dinitrate
CAS#87-33-2

Theoretical Analysis

MedKoo Cat#: 598288

Name: Isosorbide dinitrate

CAS#: 87-33-2

Chemical Formula: C6H8N2O8

Exact Mass: 236.0281

Molecular Weight: 236.13

Elemental Analysis: C, 30.52; H, 3.41; N, 11.86; O, 54.20

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
Isosorbide dinitrate; Disorlon; NSC 80038; NSC-80038; NSC80038; SST-101; Dilatrate SR; Korodil;
IUPAC/Chemical Name
(3R,3aS,6R,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate
InChi Key
MOYKHGMNXAOIAT-KVTDHHQDSA-N
InChi Code
InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4-,5-,6-/m1/s1
SMILES Code
O=[N+]([O-])O[C@H]1[C@@H](OC[C@H]2O[N+]([O-])=O)[C@@H]2OC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 236.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cossu MV, Cattaneo D, Fucile S, Pellegrino P, Baldelli S, Cozzi V, Capetti A, Clementi E. Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers. Drug Des Devel Ther. 2014 May 2;8:411-9. doi: 10.2147/DDDT.S58803. eCollection 2014. PubMed PMID: 24851040; PubMed Central PMCID: PMC4018313. 2: Jiang Z, Wei C, Sun Z, Guo J, Li R, Zhang R, Yuan G, Guo R. A simple and sensitive gas chromatography method for determination of isosorbide dinitrate and its metabolites in human plasma: application to pharmacokinetics study on oral spray. Drug Res (Stuttg). 2014 Feb;64(2):73-8. doi: 10.1055/s-0033-1351286. Epub 2013 Jul 31. PubMed PMID: 23904215. 3: Hersant B, Bosc R, Lange F, Chader H, Bouhassira J, Meningaud JP. New association of nicardipine and isosorbide dinitrate to treat internal mammary artery vasopasm in DIEP breast reconstruction. J Plast Reconstr Aesthet Surg. 2013 Dec;66(12):1807-8. doi: 10.1016/j.bjps.2013.06.028. Epub 2013 Jul 1. PubMed PMID: 23827447. 4: Romero-Gutiérrez G, Bernal González OE, Ponce-Ponce de León AL. [Comparison of isosorbide dinitrate and dinoprostone for induction of labor in term pregnancy]. Ginecol Obstet Mex. 2011 May;79(5):285-91. Spanish. PubMed PMID: 21966817. 5: Li X, Jiang Q, Du L, Li Y, Li M. Evaluation of novel immediate-/controlled-release tablets of isosorbide-5-mononitrate (5-ISMN): in vitro-in vivo correlation. Pharmazie. 2014 Feb;69(2):109-16. PubMed PMID: 24640599. 6: Winniford MD, Gabliani G, Johnson SM, Mauritson DR, Fulton KL, Hillis LD. Concomitant calcium antagonist plus isosorbide dinitrate therapy for markedly active variant angina. Am Heart J. 1984 Nov;108(5):1269-73. PubMed PMID: 6496286. 7: Vlay SC, Olson LC. Nifedipine and isosorbide dinitrate alone and in combination for patients with chronic stable angina: a double-blind crossover study. Am Heart J. 1990 Aug;120(2):303-7. PubMed PMID: 2200253. 8: Blei AT, Garcia-Tsao G, Groszmann RJ, Kahrilas P, Ganger D, Morse S, Fung HL. Hemodynamic evaluation of isosorbide dinitrate in alcoholic cirrhosis. Pharmacokinetic-hemodynamic interactions. Gastroenterology. 1987 Sep;93(3):576-83. PubMed PMID: 3301517. 9: Bidoggia H. Isosorbide-5-mononitrate and isosorbide dinitrate retard in the treatment of coronary heart disease: a multi-centre study. Curr Med Res Opin. 1987;10(9):601-11. PubMed PMID: 3325229. 10: Parker JO. Controlled release isosorbide-5-mononitrate in angina pectoris: a comparison with standard formulation isosorbide dinitrate. Can J Cardiol. 1991 Apr;7(3):125-30. PubMed PMID: 2044014. 11: Hennig L, Andresen D, Hennig A, Levenson B, Brüggemann T, Schröder R. Comparison of the effect of isosorbide-5-mononitrate and isosorbide dinitrate in a slow-release form on exercise-induced myocardial ischemia. J Clin Pharmacol. 1991 Jul;31(7):636-40. PubMed PMID: 1894759. 12: Boeker EB, Kruijer MJ, Verbeek PC. [Treatment of chronic anal fissures: diltiazem or isosorbide dinitrate as first choice?]. Ned Tijdschr Geneeskd. 2011;155:A2594. Dutch. PubMed PMID: 21262020. 13: Liu Z, Zhang B, Guo X, Chen L, Yi D, Cong J, Guo R. CGRP mediate the isosorbide-5-mononitrate cardiovascular response in healthy Chinese male volunteers through a XOR-independent pathway. Int J Clin Pharmacol Ther. 2015 Apr;53(4):325-34. doi: 10.5414/CP202178. PubMed PMID: 25740261. 14: Laufen H, Schmid M, Leitold M. Use of isosorbide dinitrate saliva concentrations for biopharmaceutical investigations. J Pharm Sci. 1983 May;72(5):496-9. PubMed PMID: 6864494. 15: Evers J, Bonn R, Boertz A, Cawello W, Dickmans HA, Weiss M. Pharmacokinetics of isosorbide dinitrate, isosorbide-2-nitrate and isosorbide-5-nitrate in renal insufficiency after repeated oral dosage. Klin Wochenschr. 1989 Mar 15;67(6):342-8. PubMed PMID: 2709744. 16: Thadani U, Fung HL, Darke AC, Parker JO. Oral isosorbide dinitrate in angina pectoris: comparison of duration of action an dose-response relation during acute and sustained therapy. Am J Cardiol. 1982 Feb 1;49(2):411-9. PubMed PMID: 7058754. 17: Hallemans R, Naeije R, Mols P, Mélot C, Reding P. Treatment of portal hypertension with isosorbide dinitrate alone and in combination with vasopressin. Crit Care Med. 1983 Jul;11(7):536-40. PubMed PMID: 6861502. 18: Kattus AA, Alvaro AB, Coulson A. Effectiveness of isosorbide dinitrate and nitroglycerin in relieving angina pectoris during uninterrupted exercise. Chest. 1975 Jun;67(6):640-6. PubMed PMID: 805037. 19: Cohen MV, Sonnenblick EH, Kirk ES. Comparative effects of nitroglycerin and isosorbide dinitrate on coronary collateral vessels and ischemic myocardium in dogs. Am J Cardiol. 1976 Feb;37(2):244-9. Review. PubMed PMID: 813510. 20: Stacher G, Bergmann H, Stacher-Janotta G, Schneider C, Steinringer H. Gastric emptying of semisolid meal unaltered by 3 days' administration of a sustained-release preparation of the nitric oxide donor, isosorbide dinitrate. Aliment Pharmacol Ther. 1997 Jun;11(3):593-7. PubMed PMID: 9218088.

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