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MedKoo Cat#: 563408 | Name: Arg-Gly-Asp
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arg-Gly-Asp is a primary sequence in cellular recognition. It is involved with the binding of proteins to cell surfaces and has strong affinity and selectivity to the alpha(V)beta(3) integrin receptors.

Chemical Structure

Arg-Gly-Asp
Arg-Gly-Asp
CAS#99896-85-2

Theoretical Analysis

MedKoo Cat#: 563408

Name: Arg-Gly-Asp

CAS#: 99896-85-2

Chemical Formula: C12H22N6O6

Exact Mass: 346.1601

Molecular Weight: 346.34

Elemental Analysis: C, 41.62; H, 6.40; N, 24.27; O, 27.72

Price and Availability

Size Price Availability Quantity
5mg USD 110.00 Ready to ship
10mg USD 180.00 Ready to ship
25mg USD 385.00 Ready to ship
50mg USD 650.00 Ready to ship
100mg USD 1,050.00 Ready to ship
200mg USD 1,750.00 2 Weeks
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Related CAS #
No Data
Synonym
Arg-Gly-Asp; Arg Gly Asp; RGD;
IUPAC/Chemical Name
Arginylglycylaspartic acid
InChi Key
IYMAXBFPHPZYIK-BQBZGAKWSA-N
InChi Code
InChI=1S/C12H22N6O6/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16)/t6-,7-/m0/s1
SMILES Code
O=C(O)C[C@@H](C(O)=O)NC(CNC([C@H](CCCNC(N)=N)N)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Certificate of Analysis
View CoA: current batch, Lot#A23M06B22
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 346.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang Y, Sun T, Jiang C. Biomacromolecules as carriers in drug delivery and tissue engineering. Acta Pharm Sin B. 2018 Jan;8(1):34-50. doi: 10.1016/j.apsb.2017.11.005. Epub 2017 Dec 9. Review. PubMed PMID: 29872621; PubMed Central PMCID: PMC5985630. 2: Rocha LA, Learmonth DA, Sousa RA, Salgado AJ. αvβ3 and α5β1 integrin-specific ligands: From tumor angiogenesis inhibitors to vascularization promoters in regenerative medicine? Biotechnol Adv. 2018 Jan - Feb;36(1):208-227. doi: 10.1016/j.biotechadv.2017.11.004. Epub 2017 Nov 15. Review. PubMed PMID: 29155160. 3: Nieberler M, Reuning U, Reichart F, Notni J, Wester HJ, Schwaiger M, Weinmüller M, Räder A, Steiger K, Kessler H. Exploring the Role of RGD-Recognizing Integrins in Cancer. Cancers (Basel). 2017 Sep 4;9(9). pii: E116. doi: 10.3390/cancers9090116. Review. PubMed PMID: 28869579; PubMed Central PMCID: PMC5615331. 4: Sun Y, Kuek V, Qiu H, Tickner J, Chen L, Wang H, He W, Xu J. The emerging role of NPNT in tissue injury repair and bone homeostasis. J Cell Physiol. 2018 Mar;233(3):1887-1894. doi: 10.1002/jcp.26013. Epub 2017 Jun 16. Review. PubMed PMID: 28513838. 5: Katsamakas S, Chatzisideri T, Thysiadis S, Sarli V. RGD-mediated delivery of small-molecule drugs. Future Med Chem. 2017 Apr;9(6):579-604. doi: 10.4155/fmc-2017-0008. Epub 2017 Apr 10. Review. PubMed PMID: 28394627. 6: Tambe V, Thakkar S, Raval N, Sharma D, Kalia K, Tekade RK. Surface Engineered Dendrimers in siRNA Delivery and Gene Silencing. Curr Pharm Des. 2017;23(20):2952-2975. doi: 10.2174/1381612823666170314104619. Review. PubMed PMID: 28292248. 7: Kafi MA, Cho HY, Choi JW. Engineered peptide-based nanobiomaterials for electrochemical cell chip. Nano Converg. 2016;3(1):17. doi: 10.1186/s40580-016-0077-7. Epub 2016 Jul 25. Review. PubMed PMID: 28191427; PubMed Central PMCID: PMC5271568. 8: Arosio D, Manzoni L, Corno C, Perego P. Integrin-Targeted Peptide- and Peptidomimetic-Drug Conjugates for the Treatment of Tumors. Recent Pat Anticancer Drug Discov. 2017;12(2):148-168. doi: 10.2174/1574892812666170203151930. Review. PubMed PMID: 28164756. 9: Huang TF, Hsu CC, Kuo YJ. Anti-thrombotic agents derived from snake venom proteins. Thromb J. 2016 Oct 4;14(Suppl 1):18. eCollection 2016. Review. PubMed PMID: 27766044; PubMed Central PMCID: PMC5056499. 10: Eo JS, Jeong JM. Angiogenesis Imaging Using (68)Ga-RGD PET/CT: Therapeutic Implications. Semin Nucl Med. 2016 Sep;46(5):419-27. doi: 10.1053/j.semnuclmed.2016.04.001. Review. PubMed PMID: 27553467. 11: Yang J, Li Y, Zhang T, Zhang X. Development of bioactive materials for glioblastoma therapy. Bioact Mater. 2016 Apr 23;1(1):29-38. doi: 10.1016/j.bioactmat.2016.03.003. eCollection 2016 Sep. Review. PubMed PMID: 29744393; PubMed Central PMCID: PMC5883963. 12: Chen H, Niu G, Wu H, Chen X. Clinical Application of Radiolabeled RGD Peptides for PET Imaging of Integrin αvβ3. Theranostics. 2016 Jan 1;6(1):78-92. doi: 10.7150/thno.13242. eCollection 2016. Review. PubMed PMID: 26722375; PubMed Central PMCID: PMC4679356. 13: Varshosaz J, Farzan M. Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma. World J Gastroenterol. 2015 Nov 14;21(42):12022-41. doi: 10.3748/wjg.v21.i42.12022. Review. PubMed PMID: 26576089; PubMed Central PMCID: PMC4641122. 14: Hussein HA, Walker LR, Abdel-Raouf UM, Desouky SA, Montasser AK, Akula SM. Beyond RGD: virus interactions with integrins. Arch Virol. 2015 Nov;160(11):2669-81. doi: 10.1007/s00705-015-2579-8. Epub 2015 Sep 1. Review. PubMed PMID: 26321473. 15: Xie Z, Cao C, Feng S, Huang J, Li Z. Progress in the research of GPIIb/IIIa antagonists. Future Med Chem. 2015;7(9):1149-71. doi: 10.4155/fmc.15.53. Review. PubMed PMID: 26132524. 16: Dal Corso A, Pignataro L, Belvisi L, Gennari C. αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology. Curr Top Med Chem. 2016;16(3):314-29. Review. PubMed PMID: 26126915. 17: Buijs PR, Verhagen JH, van Eijck CH, van den Hoogen BG. Oncolytic viruses: From bench to bedside with a focus on safety. Hum Vaccin Immunother. 2015;11(7):1573-84. doi: 10.1080/21645515.2015.1037058. Review. PubMed PMID: 25996182; PubMed Central PMCID: PMC4514197. 18: Yue N, Yuan S, Yang G. [Status and advances of RGD molecular imaging in lung cancer]. Zhongguo Fei Ai Za Zhi. 2014 Dec;17(12):855-9. doi: 10.3779/j.issn.1009-3419.2014.12.06. Review. Chinese. PubMed PMID: 25539611; PubMed Central PMCID: PMC6000408. 19: Atkinson SJ, Ellison TS, Steri V, Gould E, Robinson SD. Redefining the role(s) of endothelial αvβ3-integrin in angiogenesis. Biochem Soc Trans. 2014 Dec;42(6):1590-5. doi: 10.1042/BST20140206. Review. PubMed PMID: 25399575. 20: Riopel M, Trinder M, Wang R. Fibrin, a scaffold material for islet transplantation and pancreatic endocrine tissue engineering. Tissue Eng Part B Rev. 2015 Feb;21(1):34-44. doi: 10.1089/ten.TEB.2014.0188. Epub 2014 Jul 24. Review. PubMed PMID: 24947304.

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