Padimate O | CAS#21245-02-3 | UVB absorber

MedKoo Cat#: 461141 | Name: Padimate O

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Padimate O is a UVB absorber. It is a major ingredient in sunscreens. Padimate O exerted inhibitory effects on receptor for hyaluronic acid-mediated motility expression.

Chemical Structure

Padimate O

CAS#21245-02-3

Theoretical Analysis

MedKoo Cat#: 461141

Name: Padimate O

CAS#: 21245-02-3

Chemical Formula: C17H27NO2

Exact Mass: 277.2042

Molecular Weight: 277.41

Elemental Analysis: C, 73.61; H, 9.81; N, 5.05; O, 11.53

Price and Availability

Size	Price	Availability	Quantity
300mg	USD 725.00

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Related CAS #

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Synonym

Padimate O; Arlatone UVB; Escalol 507; Eusolex 6007;

IUPAC/Chemical Name

2-ethylhexyl 4-(dimethylamino)benzoate

InChi Key

WYWZRNAHINYAEF-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H27NO2/c1-5-7-8-14(6-2)13-20-17(19)15-9-11-16(12-10-15)18(3)4/h9-12,14H,5-8,13H2,1-4H3

SMILES Code

O=C(OCC(CC)CCCC)c1ccc(N(C)C)cc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Padimate O is a UVB absorber.

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 277.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Chang KY, Yang CH, Chou HY, Chen KC, Huang YC. Organic ultraviolet filters regulate hyaluronan metabolism in human epidermal keratinocytes through the phosphatidylinositol 3-kinase pathway. Toxicol In Vitro. 2023 Feb;86:105511. doi: 10.1016/j.tiv.2022.105511. Epub 2022 Nov 4. PMID: 36336209. 2: Adamiano A, Carella F, Degli Esposti L, Piccirillo C, Iafisco M. Calcium Phosphates from Fishery Byproducts as a Booster of the Sun Protection Factor in Sunscreens. ACS Biomater Sci Eng. 2022 Nov 14;8(11):4987-4995. doi: 10.1021/acsbiomaterials.2c00680. Epub 2022 Oct 31. PMID: 36315184. 3: Mokh S, Nassar R, Berry A, Khatib ME, Doumiati S, Taha M, Ezzeddine R, Al Iskandarani M. Chromatographic methods for the determination of a broad spectrum of UV filters in swimming pool water. Environ Sci Pollut Res Int. 2022 Mar;29(13):18605-18616. doi: 10.1007/s11356-021-16970-0. Epub 2021 Oct 25. PMID: 34697706. 4: Kim M, Shin S, Ryu D, Cho E, Yoo J, Park D, Jung E. Evaluating the Sun Protection Factor of Cosmetic Formulations Containing Afzelin. Chem Pharm Bull (Tokyo). 2021 Nov 1;69(11):1039-1044. doi: 10.1248/cpb.c21-00398. Epub 2021 Aug 28. PMID: 34456215. 5: Carve M, Nugegoda D, Allinson G, Shimeta J. A systematic review and ecological risk assessment for organic ultraviolet filters in aquatic environments. Environ Pollut. 2021 Jan 1;268(Pt B):115894. doi: 10.1016/j.envpol.2020.115894. Epub 2020 Oct 17. PMID: 33120145. 6: Muñiz-González AB, Martínez-Guitarte JL. Unveiling complex responses at the molecular level: Transcriptional alterations by mixtures of bisphenol A, octocrylene, and 2'-ethylhexyl 4- (dimethylamino)benzoate on Chironomus riparius. Ecotoxicol Environ Saf. 2020 Dec 15;206:111199. doi: 10.1016/j.ecoenv.2020.111199. Epub 2020 Sep 2. PMID: 32889307. 7: Azaroff A, Monperrus M, Miossec C, Gassie C, Guyoneaud R. Microbial degradation of hydrophobic emerging contaminants from marine sediment slurries (Capbreton Canyon) to pure bacterial strain. J Hazard Mater. 2021 Jan 15;402:123477. doi: 10.1016/j.jhazmat.2020.123477. Epub 2020 Jul 15. PMID: 32736176. 8: Horricks RA, Tabin SK, Edwards JJ, Lumsden JS, Marancik DP. Organic ultraviolet filters in nearshore waters and in the invasive lionfish (Pterois volitans) in Grenada, West Indies. PLoS One. 2019 Jul 24;14(7):e0220280. doi: 10.1371/journal.pone.0220280. PMID: 31339964; PMCID: PMC6655699. 9: Ocaña-Rios I, Peña-Alvarez A, Zuñiga-Perez I, Loeza-Fuentes E. Trace analysis of UV filters and musks in living fish by in vivo SPME-GC-MS. Anal Bioanal Chem. 2019 May;411(14):3209-3218. doi: 10.1007/s00216-019-01791-5. Epub 2019 Apr 11. PMID: 30976896. 10: Kundu M, Rahaman H, Roy MN. Physicochemical investigations on non-covalent interactions between Padimate O and cyclodextrin receptors in both solution and solid states. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jul 5;218:9-14. doi: 10.1016/j.saa.2019.03.058. Epub 2019 Mar 19. PMID: 30954802. 11: Suh HW, Lewis J, Fong L, Ramseier JY, Carlson K, Peng ZH, Yin ES, Saltzman WM, Girardi M. Biodegradable bioadhesive nanoparticle incorporation of broad- spectrum organic sunscreen agents. Bioeng Transl Med. 2018 Jul 6;4(1):129-140. doi: 10.1002/btm2.10092. PMID: 30680324; PMCID: PMC6336670. 12: Lu G, Zhou R, Li S, Dang T, Liu J. Bioaccumulation and Biomagnification of 2-Ethylhexyl-4-dimethylaminobenzoate in Aquatic Animals. Int J Environ Res Public Health. 2018 Oct 29;15(11):2395. doi: 10.3390/ijerph15112395. PMID: 30380631; PMCID: PMC6266656. 13: Muñiz-González AB, Martínez-Guitarte JL. Effects of single exposure and binary mixtures of ultraviolet filters octocrylene and 2-ethylhexyl 4-(dimethylamino) benzoate on gene expression in the freshwater insect Chironomus riparius. Environ Sci Pollut Res Int. 2018 Dec;25(35):35501-35514. doi: 10.1007/s11356-018-3516-7. Epub 2018 Oct 22. PMID: 30350147. 14: Ma C , Chan CT , Chan RC , Wong AK , Chung BP , Kwok WM . Photoprotection or photodamage: a direct observation of nonradiative dynamics from 2-ethylhexyl 4-dimethylaminobenzoate sunscreen agent. Phys Chem Chem Phys. 2018 Oct 3;20(38):24796-24806. doi: 10.1039/c8cp04447c. PMID: 30229763. 15: Cabrera-Peralta J, Peña-Alvarez A. Simple method for the determination of personal care product ingredients in lettuce by ultrasound-assisted extraction combined with solid-phase microextraction followed by GC-MS. J Sep Sci. 2018 May;41(10):2253-2260. doi: 10.1002/jssc.201701244. Epub 2018 Mar 12. PMID: 29457872. 16: Ma B, Lu G, Yang H, Liu J, Yan Z, Nkoom M. The effects of dissolved organic matter and feeding on bioconcentration and oxidative stress of ethylhexyl dimethyl p-aminobenzoate (OD-PABA) to crucian carp (Carassius auratus). Environ Sci Pollut Res Int. 2018 Mar;25(7):6558-6569. doi: 10.1007/s11356-017-1002-2. Epub 2017 Dec 19. PMID: 29255981. 17: Erol M, Çok I, Bostan Gayret Ö, Günes P, Yigit Ö, Sayman E, Günes A, Çelik DS, Hamilçikan S, Altinay S, Ercan O. Evaluation of the endocrine-disrupting effects of homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) in rat pups during the prenatal, lactation, and early postnatal periods. Toxicol Ind Health. 2017 Oct;33(10):775-791. doi: 10.1177/0748233717718974. Epub 2017 Sep 7. PMID: 28879804. 18: Giraldo A, Montes R, Rodil R, Quintana JB, Vidal-Liñán L, Beiras R. Ecotoxicological Evaluation of the UV Filters Ethylhexyl Dimethyl p-Aminobenzoic Acid and Octocrylene Using Marine Organisms Isochrysis galbana, Mytilus galloprovincialis and Paracentrotus lividus. Arch Environ Contam Toxicol. 2017 May;72(4):606-611. doi: 10.1007/s00244-017-0399-4. Epub 2017 Apr 8. PMID: 28391487. 19: Ma B, Lu G, Liu J, Yan Z, Yang H, Pan T. Bioconcentration and multi- biomarkers of organic UV filters (BM-DBM and OD-PABA) in crucian carp. Ecotoxicol Environ Saf. 2017 Jul;141:178-187. doi: 10.1016/j.ecoenv.2017.03.034. Epub 2017 Mar 27. PMID: 28343007. 20: Studziński W, Gackowska A, Przybyłek M, Gaca J. Studies on the formation of formaldehyde during 2-ethylhexyl 4-(dimethylamino)benzoate demethylation in the presence of reactive oxygen and chlorine species. Environ Sci Pollut Res Int. 2017 Mar;24(9):8049-8061. doi: 10.1007/s11356-017-8477-8. Epub 2017 Jan 29. PMID: 28133704; PMCID: PMC5384958.