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MedKoo Cat#: 598219 | Name: Lactamide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lactamide is a small organic compound structurally classified as an amide derivative of lactic acid. It has limited documented bioactivity but may act as a mild central nervous system depressant, historically investigated for potential sedative effects. Its mechanism of action is not well-characterized, though it is presumed to interact weakly with neurotransmitter systems or metabolic enzymes due to its structural similarity to endogenous lactate derivatives.

Chemical Structure

Lactamide
Lactamide
CAS#2043-43-8

Theoretical Analysis

MedKoo Cat#: 598219

Name: Lactamide

CAS#: 2043-43-8

Chemical Formula: C3H7NO2

Exact Mass: 89.0477

Molecular Weight: 89.09

Elemental Analysis: C, 40.44; H, 7.92; N, 15.72; O, 35.91

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Lactamide; NSC 61454; NSC-61454; NSC61454; Lactic acid amide;
IUPAC/Chemical Name
2-hydroxypropanamide
InChi Key
SXQFCVDSOLSHOQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C3H7NO2/c1-2(5)3(4)6/h2,5H,1H3,(H2,4,6)
SMILES Code
CC(O)C(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Lactamide is used in 2M solution as hyperosmotic agent on ciliary epithelium.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 89.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Pikulska A, Hopmann KH, Bloino J, Pecul M. Circular dichroism and optical rotation of lactamide and 2-aminopropanol in aqueous solution. J Phys Chem B. 2013 May 2;117(17):5136-47. doi: 10.1021/jp400562n. Epub 2013 Apr 12. PubMed PMID: 23530529. 2: Kashiwazaki N, Okuda Y, Seita Y, Hisamatsu S, Sonoki S, Shino M, Masaoka T, Inomata T. Comparison of glycerol, lactamide, acetamide and dimethylsulfoxide as cryoprotectants of Japanese white rabbit spermatozoa. J Reprod Dev. 2006 Aug;52(4):511-6. Epub 2006 May 8. PubMed PMID: 16679717. 3: Bekaert A, Lemoine P, Brion JD, Viossat B. Tris[(R)-lactamide-kappa2O,O']zinc(II) tetrabromozincate. Acta Crystallogr C. 2005 Feb;61(Pt 2):m76-7. Epub 2005 Jan 15. PubMed PMID: 15695896. 4: Blinkovsky AM, Markaryan AN. Synthesis of beta-lactam antibiotics containing alpha-aminophenylacetyl group in the acyl moiety catalyzed by D-(-)-phenylglycyl-beta-lactamide amidohydrolase. Enzyme Microb Technol. 1993 Nov;15(11):965-73. PubMed PMID: 7764256. 5: Sogani M, Bakre PP, Mathur N, Sharma P, Bhatnagar P. Acetamide hydrolyzing activity of Bacillus megaterium F-8 with bioremediation potential: optimization of production and reaction conditions. Environ Sci Pollut Res Int. 2014;21(14):8822-30. doi: 10.1007/s11356-014-2818-7. Epub 2014 Apr 11. PubMed PMID: 24723348. 6: Maksimova IuG, Gorbunova AN, Zorina AS, Maksimov AIu, Ovechkina GV, Demakov VA. [Transformation of amides by adherent rhodococcus cells possessing amidase activity]. Prikl Biokhim Mikrobiol. 2015 Jan-Feb;51(1):53-8. Russian. PubMed PMID: 25842904. 7: Gorbunova AN, Maksimova YG, Ovechkina GV, Maksimov AY. [Catalytic and Stereoselective Properties of the Immobilized Amidase of Rhodococcus rhodochrous 4-1]. Prikl Biokhim Mikrobiol. 2015 Sep-Oct;51(5):482-9. Russian. PubMed PMID: 26596084. 8: Ostlere L. Contact allergy to cystamine bis-lactamide. Contact Dermatitis. 2003 Jun;48(6):340. PubMed PMID: 14531878. 9: Risso-Dominguez CJ. Hydroxyethyl lactamide, a dye solvent useful in vital staining. Stain Technol. 1976 Mar;51(2):115-7. PubMed PMID: 59418. 10: Ross JS, White IR. Human studies fail to detect the allergenic potential of cystamine bis-lactamide. Contact Dermatitis. 1998 Sep;39(3):139. PubMed PMID: 9771994. 11: Budden R, Kühl UG, Buschmann G. [Studies on the pharmacodynamic activity of several drug solvents. 2. Glycerin, N-(beta-hydroxyethyl)-lactamide, polyethylene glycol 400]. Arzneimittelforschung. 1978;28(9):1579-86. German. PubMed PMID: 582559. 12: Yayanos AA. Apparent molal volume of glycine, glycolamide, alanine, lactamide, and glycylglycine in aqueous solution at 25 degrees and high pressures. J Phys Chem. 1972 Jun 8;76(12):1783-92. PubMed PMID: 5034880. 13: Petersen H, Merdan T, Kunath K, Fischer D, Kissel T. Poly(ethylenimine-co-L-lactamide-co-succinamide): a biodegradable polyethylenimine derivative with an advantageous pH-dependent hydrolytic degradation for gene delivery. Bioconjug Chem. 2002 Jul-Aug;13(4):812-21. PubMed PMID: 12121137. 14: Wang PF, Yep A, Kenyon GL, McLeish MJ. Using directed evolution to probe the substrate specificity of mandelamide hydrolase. Protein Eng Des Sel. 2009 Feb;22(2):103-10. doi: 10.1093/protein/gzn073. Epub 2008 Dec 10. PubMed PMID: 19074156. 15: Hanada A, Nagase H. Cryoprotective effects of some amides on rabbit spermatozoa. J Reprod Fertil. 1980 Sep;60(1):247-52. PubMed PMID: 7431324. 16: Kessler J, Dračínský M, Bouř P. Parallel variable selection of molecular dynamics clusters as a tool for calculation of spectroscopic properties. J Comput Chem. 2013 Feb 15;34(5):366-71. doi: 10.1002/jcc.23143. Epub 2012 Oct 10. PubMed PMID: 23047456. 17: Hudecová J, Hopmann KH, Bouř P. Correction of vibrational broadening in molecular dynamics clusters with the normal mode optimization method. J Phys Chem B. 2012 Jan 12;116(1):336-42. doi: 10.1021/jp208785a. Epub 2011 Dec 15. PubMed PMID: 22132857. 18: Kang HS, Chung HY, Jung JH, Kang SS, Choi JS. Antioxidant effect ofSalvia miltiorrhiza. Arch Pharm Res. 1997 Oct;20(5):496-500. doi: 10.1007/BF02973947. PubMed PMID: 18982497. 19: Rapoport SI, Thompson HK. Osmotic opening of the blood-brain barrier in the monkey without associated neurological deficits. Science. 1973 Jun 1;180(4089):971. PubMed PMID: 4196324. 20: Jelinekné Nikolics M, Stampf G, Rácz I. [Drug technology of a parenteral preparation for trimethoprim monotherapy]. Acta Pharm Hung. 1991 Mar;61(2):109-16. Hungarian. PubMed PMID: 1887800.

View History

JJ1

JJ1

TAPAP

TAPAP

OPC 18692

OPC 18692

Org GC 94

Org GC 94

NSC-310147

NSC-310147

Vipoglanstat

Vipoglanstat