Synonym
MRS1706; MRS 1706; MRS-1706.
IUPAC/Chemical Name
N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-1,2,3,6-tetrahydropurin-8-yl)phenoxy]acetamide
InChi Key
ZKUCFFYOQOJLGT-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)
SMILES Code
O=C(NC1=CC=C(C(C)=O)C=C1)COC2=CC=C(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
503.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Eusemann TN, Willmroth F, Fiebich B, Biber K, van Calker D. Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS One. 2015 Aug 11;10(8):e0134934. doi: 10.1371/journal.pone.0134934. PubMed PMID: 26263491; PubMed Central PMCID: PMC4532427.
3: Pejman L, Omrani H, Mirzamohammadi Z, Keyhanmanesh R. Thymoquinone, the main constituent of Nigella sativa, affects adenosine receptors in asthmatic guinea pigs. Iran J Basic Med Sci. 2014 Dec;17(12):1012-9. PubMed PMID: 25859306; PubMed Central PMCID: PMC4387224.
4: Pejman L, Omrani H, Mirzamohammadi Z, Shahbazfar AA, Khalili M, Keyhanmanesh R. The Effect of Adenosine A2A and A2B Antagonists on Tracheal Responsiveness, Serum Levels of Cytokines and Lung Inflammation in Guinea Pig Model of Asthma. Adv Pharm Bull. 2014;4(2):131-8. doi: 10.5681/apb.2014.020. PubMed PMID: 24511476; PubMed Central PMCID: PMC3915812.
