Pneumadin | CAS#130918-90-0 | triggers antidiuresis| MedKoo

MedKoo Cat#: 592427 | Name: Pneumadin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pneumadin is a lung peptide which triggers antidiuresis; the rat peptide begins with Tyr and the peptide from human fetal lungs has Ala instead of Tyr.

Chemical Structure

Pneumadin

CAS#130918-90-0

Theoretical Analysis

MedKoo Cat#: 592427

Name: Pneumadin

CAS#: 130918-90-0

Chemical Formula: C47H74N12O15

Exact Mass: 1046.5397

Molecular Weight: 1047.18

Elemental Analysis: C, 53.91; H, 7.12; N, 16.05; O, 22.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Pneumadin

IUPAC/Chemical Name

(S)-4-(2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)acetamido)-5-((S)-2-(((3S,9S,12S,15S,18S)-22-amino-3-carbamoyl-12-(carboxymethyl)-15-isobutyl-2,9-dimethyl-5,8,11,14,17-pentaoxo-4,7,10,13,16-pentaazadocosan-18-yl)carbamoyl)pyrrolidin-1-yl)-5-oxopentanoic acid

InChi Key

KBSORCBSCSOBHH-IHJZLXGESA-N

InChi Code

InChI=1S/C47H74N12O15/c1-24(2)19-32(45(72)57-33(21-38(65)66)44(71)53-26(5)41(68)51-23-36(62)58-39(25(3)4)40(50)67)56-43(70)30(9-6-7-17-48)55-46(73)34-10-8-18-59(34)47(74)31(15-16-37(63)64)54-35(61)22-52-42(69)29(49)20-27-11-13-28(60)14-12-27/h11-14,24-26,29-34,39,60H,6-10,15-23,48-49H2,1-5H3,(H2,50,67)(H,51,68)(H,52,69)(H,53,71)(H,54,61)(H,55,73)(H,56,70)(H,57,72)(H,58,62)(H,63,64)(H,65,66)/t26-,29-,30-,31-,32-,33-,34-,39-/m0/s1

SMILES Code

C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC(CNC([C@@H](N)Cc2ccc(O)cc2)=O)=O)CCC(O)=O)=O)=O)CCCCN)=O)CC(C)C)=O)CC(O)=O)=O)C(NCC(N[C@H](C(N)=O)C(C)C)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,047.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Miskowiak B, Brelinska R, Kosowicz J, Konwerska A, Ziolkowska A, Belloni AS, Nussdorfer GG, Malendowicz LK. Pneumadin in the ventral prostate of rats during postnatal development: a radioimmunological and immunocytochemical study. Int J Mol Med. 2004 Jun;13(6):801-3. PubMed PMID: 15138615. 2: Kosowicz J, Miskowiak B, Konwerska A, Belloni AS, Nussdorfer GG, Malendowicz LK. Pneumadin in the rat ventral prostate and its hormonal regulation. Horm Metab Res. 2004 Feb;36(2):78-81. PubMed PMID: 15002055. 3: Miśkowiak B, Kosowicz J, Konwerska A, Ziółkowska A, Nussdorfer GG, Malendowicz LK. Pneumadin in the ventral prostate and seminal vesicles of estradiol-treated rats: RIA and immunocytochemical studies. Folia Histochem Cytobiol. 2003;41(4):219-22. PubMed PMID: 14677761. 4: Kosowicz J, Miskowiak B, Konwerska A, Tortorella C, Nussdorfer GG, Malendowicz LK. Tissue distribution of pneumadin immunoreactivity in the rat. Peptides. 2003 Feb;24(2):215-20. PubMed PMID: 12668205. 5: Batra VK, Hopfner RL, Gopalakrishnan V, McNeill JR. Pneumadin-evoked intracellular free Ca2+ responses in rat aortic smooth muscle cells: effect of dexamethasone. Biochem Pharmacol. 1999 Jul 1;58(1):177-82. PubMed PMID: 10403532. 6: Markowska A, Andreis PG, Miskowiak B, Nussdorfer GG, Malendowicz LK. Effects of pneumadin (PNM) on the adrenal glands. 6. Further studies on the inhibitory effect of PNM on dexamethasone-induced atrophy of the rat adrenal cortex. Histol Histopathol. 1997 Jul;12(3):677-82. PubMed PMID: 9225150. 7: Markowska A, Macchi C, Nussdorfer GG, Malendowicz LK. Effects of pneumadin (PNM) on the adrenal glands. 5. Potent stimulating action of PNM on adrenocortical growth of dexamethasone-administered rats. Histol Histopathol. 1996 Jul;11(3):583-5. PubMed PMID: 8839748. 8: Watson JD, Jennings DB, Sarda IR, Pang SC, Lawson B, Wigle DA, Flynn TG. The antidiuretic effect of pneumadin requires a functional arginine vasopressin system. Regul Pept. 1995 May 30;57(2):105-14. PubMed PMID: 7659786. 9: Batra VK, Mathur M, Mir SA, Kapoor R, Kumar MA. Pneumadin: a new lung peptide which triggers antidiuresis. Regul Pept. 1990 Sep 10;30(2):77-87. PubMed PMID: 2274681.