Synonym
BMY 25368; BMY25368; BMY-25368
IUPAC/Chemical Name
3-Amino-4-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]cyclobut-3-ene-1,2-dione
InChi Key
KSBYXRUNSLGUNE-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H25N3O3/c20-16-17(19(24)18(16)23)21-8-5-11-25-15-7-4-6-14(12-15)13-22-9-2-1-3-10-22/h4,6-7,12,21H,1-3,5,8-11,13,20H2
SMILES Code
O=C1C(C(N)=C1NCCCOC2=CC=CC(CN3CCCCC3)=C2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
343.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Baumeister P, Erdmann D, Biselli S, Kagermeier N, Elz S, Bernhardt G, Buschauer A. [(3) H]UR-DE257: development of a tritium-labeled squaramide-type selective histamine H2 receptor antagonist. ChemMedChem. 2015 Jan;10(1):83-93. doi: 10.1002/cmdc.201402344. Epub 2014 Oct 15. PubMed PMID: 25320025.
2: Wilder-Smith CH, Merki HS. Is the time of dosing of a potent long-acting H2-receptor antagonist critical? Twenty-four-hour pH measurements with SKF-94482. Scand J Gastroenterol. 1991 May;26(5):501-7. PubMed PMID: 1678550.
3: Orsini JA, Dreyfuss DJ, Vecchione J, Spencer PA, Uhlman R. Effects of a histamine type-2 receptor antagonist (BMY-25368) on gastric secretion in horses. Am J Vet Res. 1991 Jan;52(1):108-10. PubMed PMID: 1673593.
4: Gavey CJ, Smith JT, Nwokolo CU, Pounder RE. The effect of SK&F 94482 (BMY-25368) on 24-hour intragastric acidity and plasma gastrin concentration in healthy subjects. Aliment Pharmacol Ther. 1989 Dec;3(6):557-64. PubMed PMID: 2577500.
5: Cavanagh RL, Buyniski JP. Effect of BMY-25368, a potent and long-acting histamine H2-receptor antagonist, on gastric secretion and aspirin-induced gastric lesions in the dog. Aliment Pharmacol Ther. 1989 Jun;3(3):299-313. PubMed PMID: 2577694.
6: Chiverton SG, Burget DW, Hunt RH. Do H2 receptor antagonists have to be given at night? A study of the antisecretory profile of SKF 94482, a new H2 receptor antagonist which has a profound effect on daytime acidity. Gut. 1989 May;30(5):594-9. PubMed PMID: 2567265; PubMed Central PMCID: PMC1434200.
7: O'Neill KA, Gertner SB. Effects of centrally administered H2 antagonists on motor activity. Pharmacol Biochem Behav. 1987 Apr;26(4):683-6. PubMed PMID: 2885855.
