Synonym
Alanylaspartic acid; NSC 186912; NSC-186912; NSC186912
IUPAC/Chemical Name
L-Aspartic acid, N-L-alanyl-
InChi Key
XAEWTDMGFGHWFK-IMJSIDKUSA-N
InChi Code
InChI=1S/C7H12N2O5/c1-3(8)6(12)9-4(7(13)14)2-5(10)11/h3-4H,2,8H2,1H3,(H,9,12)(H,10,11)(H,13,14)/t3-,4-/m0/s1
SMILES Code
O=C(O)C[C@@H](C(O)=O)NC([C@H](C)N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
207.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yang S, Liu X, Zhang M, Lin S, Chen F. Moisture-Absorption and Water Dynamics in the Powder of Egg Albumen Peptide, Met-Pro-Asp-Ala-His-Leu. J Food Sci. 2017 Jan;82(1):53-60. doi: 10.1111/1750-3841.13573. Epub 2016 Dec 5. PubMed PMID: 27918611.
2: Flook AM, Yang J, Miao Y. Substitution of the Lys linker with the β-Ala linker dramatically decreased the renal uptake of 99mTc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated α-melanocyte stimulating hormone peptides. J Med Chem. 2014 Nov 13;57(21):9010-8. doi: 10.1021/jm501114v. Epub 2014 Oct 16. PubMed PMID: 25290883; PubMed Central PMCID: PMC4234429.
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5: Lesage A, Duma L, Sakellariou D, Emsley L. Improved resolution in proton NMR spectroscopy of powdered solids. J Am Chem Soc. 2001 Jun 20;123(24):5747-52. PubMed PMID: 11403608.
6: Jin W, Hopfer U. Dipeptide-induced Cl- secretion in proximal tubule cells. Am J Physiol. 1997 Nov;273(5 Pt 1):C1623-31. PubMed PMID: 9374648.
7: Brandsch M, Brandsch C, Ganapathy ME, Chew CS, Ganapathy V, Leibach FH. Influence of proton and essential histidyl residues on the transport kinetics of the H+/peptide cotransport systems in intestine (PEPT 1) and kidney (PEPT 2). Biochim Biophys Acta. 1997 Mar 13;1324(2):251-62. PubMed PMID: 9092712.
8: Eggleston DS, Hodgson DJ. Conformation and structure of acidic dipeptides. Crystal structures of L-alanyl-L-aspartic acid and alpha-L-glutamyl-L-aspartic acid. Int J Pept Protein Res. 1983 Mar;21(3):288-95. PubMed PMID: 6853030.
