MedKoo Cat#: 524626 | Name: Cgp 31523A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cgp 31523A is a new aminothiazolyl cephalosporin. CGP 31523A inhibited E. coli, K. pneumoniae, P. mirabilis, C. diversus, K. oxytoca, P. stuartii, Salmonella and Shigella at less than or equal to 0.25 micrograms/ml. It was equal or 2-fold more active than cefotaxime and ceftazidime, and 4-fold more active than imipenem against these organisms.

Chemical Structure

Cgp 31523A
Cgp 31523A
CAS#94714-78-0

Theoretical Analysis

MedKoo Cat#: 524626

Name: Cgp 31523A

CAS#: 94714-78-0

Chemical Formula: C16H15N7O5S4

Exact Mass: 513.0018

Molecular Weight: 513.59

Elemental Analysis: C, 37.42; H, 2.94; N, 19.09; O, 15.58; S, 24.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Cgp 31523A; Cgp31523A; Cgp-31523A.
IUPAC/Chemical Name
(6R,7R)-3-(((1,2,3-thiadiazol-5-yl)thio)methyl)-7-(2-(2-aminothiazol-4-yl)-2-formamidoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChi Key
MLLOBKWZTXROPZ-WUMONGPASA-N
InChi Code
InChI=1S/C16H15N7O5S4/c17-16-20-7(4-31-16)9(18-5-24)12(25)21-10-13(26)23-11(15(27)28)6(3-30-14(10)23)2-29-8-1-19-22-32-8/h1,4-5,9-10,14H,2-3H2,(H2,17,20)(H,18,24)(H,21,25)(H,27,28)/t9?,10-,14-/m1/s1
SMILES Code
c1c(snn1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)C(c4csc(n4)N)NC=O)SC2)C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 513.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tuomanen E, Gilbert K, Tomasz A. Modulation of bacteriolysis by cooperative effects of penicillin-binding proteins 1a and 3 in Escherichia coli. Antimicrob Agents Chemother. 1986 Nov;30(5):659-63. PubMed PMID: 3541782; PubMed Central PMCID: PMC176509. 2: Chin NX, Neu HC. Comparative in vitro activity and beta-lactamase stability of CGP 31523A, a new aminothiazolyl cephalosporin. Chemioterapia. 1986 Apr;5(2):92-100. PubMed PMID: 3518967. 3: Wise R, Cross C, Andrews JM. In vitro activity of CGP 31523A, a broad-spectrum cephalosporin, in comparison with those of other agents. Antimicrob Agents Chemother. 1984 Dec;26(6):876-80. PubMed PMID: 6524904; PubMed Central PMCID: PMC180042.