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MedKoo Cat#: 461073 | Name: Fenclofenac

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fenclofenac is a non-steroidal anti-inflammatory agent that competitively inhibits the binding of thyroxine(T4) and triiodothyronine (T3) by thyroxine-binding globulin(TBG).

Chemical Structure

Fenclofenac
Fenclofenac
CAS#34645-84-6

Theoretical Analysis

MedKoo Cat#: 461073

Name: Fenclofenac

CAS#: 34645-84-6

Chemical Formula: C14H10Cl2O3

Exact Mass: 296.0007

Molecular Weight: 297.13

Elemental Analysis: C, 56.59; H, 3.39; Cl, 23.86; O, 16.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Fenclofenac; Flenac; R 67408; R-67408; R67408; Rx 67408; Rx-67408; Rx67408;
IUPAC/Chemical Name
2-(2-(2,4-dichlorophenoxy)phenyl)acetic acid
InChi Key
IDKAXRLETRCXKS-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18)
SMILES Code
O=C(O)CC1=CC=CC=C1OC2=CC=C(Cl)C=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 297.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bedi SS, Eberl R, Million R, Silas AM. Fenclofenac and diclofenac in the treatment of rheumatoid arthritis. Br J Rheumatol. 1984 Aug;23(3):214-9. PubMed PMID: 6378307. 2: Kurtz AB, Capper SJ, Clifford J, Humphrey MJ, Lukinac L. The effect of fenclofenac on thyroid function. Clin Endocrinol (Oxf). 1981 Aug;15(2):117-24. PubMed PMID: 6796298. 3: Greenslade D, Havler ME, Humphrey MJ, Jordan BJ, Rance MJ. Species differences in the metabolism and excretion of fenclofenac. Xenobiotica. 1980 Oct;10(10):753-60. PubMed PMID: 7456491. 4: Marsh MV, Caldwell J, Sloan TP, Smith RL, Horner M, Moss MS. The metabolism of fenclofenac in the horse. Xenobiotica. 1983 Apr;13(4):233-40. PubMed PMID: 6624138. 5: Lund B, Graae A, Sonne I, Andersen RB. Long-term treatment of rheumatoid arthritis with fenclofenac or gold: a controlled, single blind trial comparing clinical and biochemical parameters. Eur J Rheumatol Inflamm. 1983;6(3):279-87. PubMed PMID: 6391933. 6: Humphrey MJ, Capper SJ, Kurtz AB. Fenclofenac and thyroid hormone concentrations. Lancet. 1980 Mar 1;1(8166):487-8. PubMed PMID: 6102216. 7: Spiers EM, Tavendale A, MacConnachie A, Beck JS. The effect of non-steroidal anti-inflammatory drugs on phytohaemagglutinin stimulated lymphocytes: relevance to possible therapeutic immunosuppression by fenclofenac. Int J Immunopharmacol. 1988;10(3):261-9. PubMed PMID: 2460411. 8: Ratcliffe WA, Hazelton RA, Thomson JA, Ratcliffe JG. The effect of fenclofenac on thyroid function tests in vivo and in vitro. Clin Endocrinol (Oxf). 1980 Dec;13(6):569-75. PubMed PMID: 7226571. 9: Ferguson MM, Wiesenfeld D, MacDonald DG. Oral mucosal lichenoid eruption due to fenclofenac. J Oral Med. 1984 Jan-Mar;39(1):39-40. PubMed PMID: 6232357. 10: Taylor R, Hutton C, Weeke J, Clark F. Fenclofenac-secondary effects upon the pituitary thyroid axis. Clin Endocrinol (Oxf). 1983 Dec;19(6):683-92. PubMed PMID: 6418419. 11: Bachmann F. [Fenclofenac in the treatment of rheumatoid arthritis (author's transl)]. Dtsch Med Wochenschr. 1980 Dec 26;105(52):1806-9. German. PubMed PMID: 7004827. 12: Dunagan FM, McGill PE, Kelman AW, Whiting B. Quantitation of dose and concentration-effect relationships for fenclofenac in rheumatoid arthritis. Br J Clin Pharmacol. 1986 Apr;21(4):409-16. PubMed PMID: 3518772; PubMed Central PMCID: PMC1400933. 13: Henson R, Lloyd-Jones JG, Nichols JD, Jordan BJ. Pharmacokinetics of fenclofenac following single and multiple doses. Eur J Drug Metab Pharmacokinet. 1980;5(4):217-23. PubMed PMID: 7250145. 14: Farr M, Struthers GR, Scott DG, Bacon PA. Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis. Br J Rheumatol. 1985 Nov;24(4):367-9. PubMed PMID: 4063627. 15: Sellars L, Wilkinson R, Morley AR, Salter RH. Nephrotic syndrome and renal impairment associated with fenclofenac. Ann Rheum Dis. 1984 Jun;43(3):513-4. PubMed PMID: 6742914; PubMed Central PMCID: PMC1001383. 16: Raftery MJ, Forman P, Farrington K, Sweny P, Moorhead JF. Fenclofenac induced interstitial nephritis confirmed by inadvertent rechallenge. Br Med J (Clin Res Ed). 1985 Apr 20;290(6476):1178-9. PubMed PMID: 3921143; PubMed Central PMCID: PMC1418881. 17: Berry H, Ford-Hutchinson AW, Camp AV, Heywood D, Molloy MG, James DW, Hamilton EB. Antirheumatic activity of fenclofenac. Ann Rheum Dis. 1980 Oct;39(5):473-5. PubMed PMID: 7002066; PubMed Central PMCID: PMC1000588. 18: Thompson M, Akyol MS. A controlled comparative trial of Butacote and fenclofenac in the treatment of ankylosing spondylitis. J Int Med Res. 1977;5 Suppl 2:96-9. PubMed PMID: 334611. 19: Atkinson DC, Leach EC. Effect of fenclofenac on prostaglandin production in carageenin air bleb exudates in rats. Agents Actions. 1978 Apr;8(3):263-7. PubMed PMID: 665437. 20: Atkinson DC, Leach EC. Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac). Agents Actions. 1976 Sep;6(5):657-66. PubMed PMID: 970297.