R 50595 | CAS#104860-61-9 | cisapride antagonist

MedKoo Cat#: 461067 | Name: R 50595

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R 50595 is a selective non-competitive antagonist of cisapride.

Chemical Structure

R 50595

CAS#104860-61-9

Theoretical Analysis

MedKoo Cat#: 461067

Name: R 50595

CAS#: 104860-61-9

Chemical Formula: C30H35Cl2F2N3O3

Exact Mass: 593.2024

Molecular Weight: 594.52

Elemental Analysis: C, 60.61; H, 5.93; Cl, 11.93; F, 6.39; N, 7.07; O, 8.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

R 50595; R-50595; R50595;

IUPAC/Chemical Name

4-amino-N-((3S,4R)-1-(4,4-bis(4-fluorophenyl)butyl)-3-methoxypiperidin-4-yl)-5-chloro-2-methoxybenzamide hydrochloride

InChi Key

ODGIHIUVACVQTA-KIIRSEDSSA-N

InChi Code

InChI=1S/C30H34ClF2N3O3.ClH/c1-38-28-17-26(34)25(31)16-24(28)30(37)35-27-13-15-36(18-29(27)39-2)14-3-4-23(19-5-9-21(32)10-6-19)20-7-11-22(33)12-8-20;/h5-12,16-17,23,27,29H,3-4,13-15,18,34H2,1-2H3,(H,35,37);1H/t27-,29+;/m1./s1

SMILES Code

O=C(N[C@H]1[C@@H](OC)CN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC(Cl)=C(N)C=C4OC.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 594.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Van den Brink HW, Schuurkes JA, Van Nueten JM, Van Rossum JM. R 50 595, a selective non-competitive antagonist of cisapride, BRL 24924 and 5-hydroxytryptamine on the guinea-pig ileum. Eur J Pharmacol. 1990 May 31;181(1-2):119-25. PubMed PMID: 2387319. 2: Meulemans AL, Schuurkes JA. Is the action of cisapride on the guinea-pig ileum mediated via 5-HT4 receptors? Eur J Pharmacol. 1992 Feb 25;212(1):51-9. PubMed PMID: 1555639.