163-BP3 | CAS# | photoaffinity probe

MedKoo Cat#: 561347 | Name: 163-BP3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

163-BP3 is a potent photoaffinity probe that targets gamma-secretase. Gamma-secretase is a multiprotein complex that catalyzes intramembrane proteolysis associated with Alzheimer's disease and cancer.

Chemical Structure

163-BP3

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 561347

Name: 163-BP3

CAS#: Unknown

Chemical Formula: C28H25F3N2O5S

Exact Mass: 558.1436

Molecular Weight: 558.57

Elemental Analysis: C, 60.21; H, 4.51; F, 10.20; N, 5.02; O, 14.32; S, 5.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

163-BP3; 163 BP3; 163BP3;

IUPAC/Chemical Name

(R)-5,5,5-trifluoro-2-(N-(4-(4-(prop-2-yn-1-yloxy)benzoyl)benzyl)phenylsulfonamido)pentanamide

InChi Key

ITJWFVOVZQGYOY-RUZDIDTESA-N

InChi Code

InChI=1S/C28H25F3N2O5S/c1-2-18-38-23-14-12-22(13-15-23)26(34)21-10-8-20(9-11-21)19-33(25(27(32)35)16-17-28(29,30)31)39(36,37)24-6-4-3-5-7-24/h1,3-15,25H,16-19H2,(H2,32,35)/t25-/m1/s1

SMILES Code

FC(CC[C@H](C(N)=O)N(S(=O)(C1=CC=CC=C1)=O)CC2=CC=C(C(C3=CC=C(OCC#C)C=C3)=O)C=C2)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 558.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Crump CJ, Murrey HE, Ballard TE, Am Ende CW, Wu X, Gertsik N, Johnson DS, Li YM. Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase. ACS Chem Neurosci. 2016 Aug 17;7(8):1166-73. doi: 10.1021/acschemneuro.6b00127. Epub 2016 Jun 17. PubMed PMID: 27253220.