K 41 | CAS# 53026-37-2 | Polycyclic Polyether Antibiotic

MedKoo Cat#: 598150 | Name: K-41

Description:

WARNING: This product is for research use only, not for human or veterinary use.

K 41 is a polycyclic polyether antibiotic isolated from Streptomyces hygroscopicus.

Chemical Structure

K-41

CAS#53026-37-2

Theoretical Analysis

MedKoo Cat#: 598150

Name: K-41

CAS#: 53026-37-2

Chemical Formula: C48H82O18

Exact Mass: 946.5501

Molecular Weight: 947.16

Elemental Analysis: C, 60.87; H, 8.73; O, 30.40

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Synonym

K 41; K41; K-41; Antibiotic K-41A; Antibiotic A 32887; 37454 RP; Antibiotic 37454 RP;

IUPAC/Chemical Name

2-hydroxy-2-((2R,3R,4R,5R,6R)-2-hydroxy-6-(((2S,5R,7S,9R,10R)-2-(5'-(6-hydroxy-4-((5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)octahydro-[2,2'-bifuran]-5-yl)-3,9-dimethoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-4,5-dimethoxy-3,5-dimethyltetrahydro-2H-pyran-2-yl)acetic acid

InChi Key

QFHLVPYVNFSTBE-YUJCGUFPSA-N

InChi Code

InChI=1S/C48H82O18/c1-23-38(62-37-20-18-30(54-10)28(6)59-37)25(3)46(9,52)65-39(23)33-16-15-31(60-33)32-17-19-35(61-32)45(8)42(57-13)27(5)48(66-45)24(2)34(55-11)21-29(63-48)22-36-44(7,58-14)41(56-12)26(4)47(53,64-36)40(49)43(50)51/h23-42,49,52-53H,15-22H2,1-14H3,(H,50,51)/t23?,24-,25?,26-,27?,28?,29+,30?,31?,32?,33?,34-,35?,36-,37?,38?,39?,40?,41-,42?,44-,45+,46?,47-,48-/m1/s1

SMILES Code

O=C(O)C(O)[C@@]1(O)[C@H](C)[C@@H](OC)[C@](C)(OC)[C@@H](C[C@H](C[C@@H](OC)[C@H]2C)O[C@@]32C(C)C(OC)[C@@](C4CCC(C5OC(C6C(C)C(OC7CCC(OC)C(C)O7)C(C)C(C)(O)O6)CC5)O4)(C)O3)O1

Appearance

Solid powder

Purity

>70% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 947.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hoshi M, Shimotohno KW, Endo T, Furihata K, Seto H. Microbial and chemical conversion of antibiotic K-41. I. Isolation and identification of conversion product. J Antibiot (Tokyo). 1997 Jul;50(7):631-4. PubMed PMID: 9711256. 2: Otoguro K, Ishiyama A, Ui H, Kobayashi M, Manabe C, Yan G, Takahashi Y, Tanaka H, Yamada H, Omura S. In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia. J Antibiot (Tokyo). 2002 Sep;55(9):832-4. PubMed PMID: 12458776. 3: Dirlam JP, Bordner J, Cullen WP, Jefferson MT, Presseau-Linabury L. The structure of CP-96,797, a polyether antibiotic related to K-41A and produced by Streptomyces sp. J Antibiot (Tokyo). 1992 Jul;45(7):1187-9. PubMed PMID: 1517165. 4: Hoshi M, Endo T. Microbial and chemical conversion of antibiotic K41. II. Preparation of K41-DA1, -DA2 and -DA3 deamicetosyl derivatives of antibiotic K41. J Antibiot (Tokyo). 2000 Oct;53(10):1154-7. PubMed PMID: 11132961.