Synonym
Hydroxyphenamate; NSC 108034; NSC-108034
IUPAC/Chemical Name
1,2-Butanediol, 2-phenyl-, 1-carbamate
InChi Key
WAFIYOULDIWAKR-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H15NO3/c1-2-11(14,8-15-10(12)13)9-6-4-3-5-7-9/h3-7,14H,2,8H2,1H3,(H2,12,13)
SMILES Code
CCC(O)(C1=CC=CC=C1)COC(N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
209.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gurney BF. Chemotherapy in dental practice barbiturate substitures. 4. Hydroxyphenamate and oxanamide. Dent Dig. 1970 Feb;76(2):112-3. PubMed PMID: 5262943.
2: Miller MJ, Shettel R, Fiedler HT. Chronic toxicologic evaluation of hydroxyphenamate and possible synergism with phenothiazines. Psychosomatics. 1965 Sep-Oct;6(5):340-2. PubMed PMID: 5319246.
3: ESSMAN WB. HYDROXYPHENAMATE-INDUCED ATTENUATION OF CONDITIONED AVOIDANCE BEHAVIOR IN MICE. Arch Int Pharmacodyn Ther. 1964 Oct 1;151:510-4. PubMed PMID: 14228064.
4: GREENWALD AS. RELIEF OF TENSION IN DENTAL PATIENTS: A CONTROLLED STUDY WITH HYDROXYPHENAMATE. J Am Dent Assoc. 1964 May;68:708-14. PubMed PMID: 14143882.
5: HSU JJ, BRAUN RA, DOMINO EF, LOWINGER P, SCHORER C, BRUCK M. CLINICAL EVALUATION OF HYDROXYPHENAMATE IN PSYCHOTIC PATIENTS. Dis Nerv Syst. 1963 Dec;24:750-1. PubMed PMID: 14096608.
6: HUFFMAN WJ, FLORIO AE, PAYNE JL, BOYS FE. The influence of two selected tranquilizers on driving skills. Am J Psychiatry. 1963 Mar;119:885-6. PubMed PMID: 13955504.
7: MEYER J, BUSWELL M. Impressions of the possible effects of a new tranquilizer, hydroxyphenamate. Am J Psychiatry. 1962 Nov;119:463-4. PubMed PMID: 13935281.
8: ABBOTT JA, SCHOLL ML, SCHWAB RS, ENGLAND AC Jr. A report on the apparent anticonvulsant effect of hydroxyphenamate (Listica). Dis Nerv Syst. 1962 Sep;23:519-21. PubMed PMID: 13858828.
9: HUBATA JA, HECHT RA. Review of clinical use of hydroxyphenamate in 1759 patients. Clin Med (Northfield). 1962 Jul;69:1594-8. PubMed PMID: 15445778.
10: MCLAUGHLIN BE. Symposium on hydroxyphenamate. Introduction. Dis Nerv Syst. 1961 Sep;22(9)Suppl:5-6. PubMed PMID: 13774073.
11: GREENSPAN EB. Use of hydroxyphenamate in some forms of cardiovascular disease. Dis Nerv Syst. 1961 Sep;22(9)Suppl:33-5. PubMed PMID: 13708349.
12: GOULDMAN C, LUNDE F, DAVIS J. Clinical trial of hydroxyphenamate (Listica) in alcoholic patients. Dis Nerv Syst. 1961 Sep;22(9)Suppl:44-6. PubMed PMID: 13707512.
13: CAHN MM, LEVY EJ. Use of hydroxyphenamate (Listica) in dermatologic therapy. Dis Nerv Syst. 1961 Sep;22(9)Suppl:47-9. PubMed PMID: 13689809.
14: CAHN B. Effect of hydroxyphenamate in the treatment of mild and moderate anxiety states. (A double blind study with crossover pattern). Dis Nerv Syst. 1961 Sep;22(9)Suppl:30-2. PubMed PMID: 13689796.
15: ALEXANDER L. Effect of hydroxyphenamate on the conditional psychogalvanic reflex in man. Dis Nerv Syst. 1961 Sep;22(9)Suppl:17-24. PubMed PMID: 13682351.
