Wy 27127 | CAS#95669-35-5 | antagonist

MedKoo Cat#: 585429 | Name: Wy 27127

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Wy 27127 is an alpha 2-adrenoceptors antagonist that has estimated potency based on ability to block clonidine-induced inhibition of electrically-evoked contractions of the rat isolated vas deferens.

Chemical Structure

Wy 27127

CAS#95669-35-5

Theoretical Analysis

MedKoo Cat#: 585429

Name: Wy 27127

CAS#: 95669-35-5

Chemical Formula: C17H27N3O4S2

Exact Mass: 401.1443

Molecular Weight: 401.54

Elemental Analysis: C, 50.85; H, 6.78; N, 10.46; O, 15.94; S, 15.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Wy 27127; Wy27127; Wy-27127

IUPAC/Chemical Name

N-[2-[[(2R,11bS)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-methylsulfonylamino]ethyl]methanesulfonamide

InChi Key

VSQCTWPNMPWYSD-WBVHZDCISA-N

InChi Code

InChI=1S/C17H27N3O4S2/c1-25(21,22)18-9-12-20(26(2,23)24)15-8-11-19-10-7-14-5-3-4-6-16(14)17(19)13-15/h3-6,15,17-18H,7-13H2,1-2H3/t15-,17+/m1/s1

SMILES Code

CS(=O)(NCCN([C@@H]1CCN2CCC3=CC=CC=C3[C@]2([H])C1)S(=O)(C)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 401.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bill SJ, Boniface A, Haroun F, McAdams RP, Lattimer N, Rhodes KF. Some pharmacological properties of Wy 27127 a more selective alpha 2:alpha 1-adrenoceptor antagonist than idazoxan in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):418-22. PubMed PMID: 2881217. 2: Blaxall HS, Murphy TJ, Baker JC, Ray C, Bylund DB. Characterization of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line. J Pharmacol Exp Ther. 1991 Oct;259(1):323-9. PubMed PMID: 1656026. 3: Loomis CW, Arunachalam KD. Intrathecal St-587: effects on nociceptive reflexes and blood pressure in the rat. J Pharmacol Exp Ther. 1992 Nov;263(2):428-35. PubMed PMID: 1331398. 4: Wy 27127: A Peripherally Acting Alpha-2 Adrenoceptor Antagonist: HARTLEY JE and FLETCHER A. Wyeth Research (UK) Ltd., Huntercombe Lane South, Taplow, Maidenhead, Berks. SL6 0PH. J Psychopharmacol. 1992 Jan;6(1):106. doi: 10.1177/026988119200600131. PubMed PMID: 22291259. 5: Rhodes KF, Waterfall JF. The effects of some alpha-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine. Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):261-8. PubMed PMID: 2884574.