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MedKoo Cat#: 584480 | Name: Iosimenol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iosimenol is contrast agent that contains 350 mg iodine/mL.

Chemical Structure

Iosimenol
Iosimenol
CAS#181872-90-2

Theoretical Analysis

MedKoo Cat#: 584480

Name: Iosimenol

CAS#: 181872-90-2

Chemical Formula: C31H36I6N6O14

Exact Mass: 1477.6558

Molecular Weight: 1478.08

Elemental Analysis: C, 25.19; H, 2.46; I, 51.51; N, 5.69; O, 15.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BP-13; ICJ 3393; ICJ-3393; Iosimenol; MP-3047-04
IUPAC/Chemical Name
5-[[3-[3-carbamoyl-N-(2,3-dihydroxypropyl)-5-(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodoanilino]-3-oxopropanoyl]-(2,3-dihydroxypropyl)amino]-3-N-(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
InChi Key
DLPPIGPJCKKVBA-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H36I6N6O14/c32-20-16(28(38)54)22(34)26(24(36)18(20)30(56)40-2-10(48)6-44)42(4-12(50)8-46)14(52)1-15(53)43(5-13(51)9-47)27-23(35)17(29(39)55)21(33)19(25(27)37)31(57)41-3-11(49)7-45/h10-13,44-51H,1-9H2,(H2,38,54)(H2,39,55)(H,40,56)(H,41,57)
SMILES Code
O=C(C1=C(I)C(N(C(CC(N(CC(O)CO)C2=C(I)C(C(NCC(O)CO)=O)=C(I)C(C(N)=O)=C2I)=O)=O)CC(O)CO)=C(I)C(C(NCC(O)CO)=O)=C1I)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,478.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hirao Y, Kashiyama E, Umehara K, Kohno M, Ikei N, Hogstrom B. Hemodialysis clearance of iosimenol, a novel iso-osmolar radiographic contrast medium. Acta Radiol. 2014 Oct;55(8):938-44. doi: 10.1177/0284185113508113. Epub 2013 Oct 12. PubMed PMID: 24123996. 2: Meurer K, Kelsch B, Hogstrom B. The pharmacokinetic profile, tolerability and safety of the iodinated, non-ionic, dimeric contrast medium Iosimenol 340 injection in healthy human subjects. Acta Radiol. 2015 May;56(5):581-6. doi: 10.1177/0284185114534414. Epub 2014 Jun 3. PubMed PMID: 24895062; PubMed Central PMCID: PMC4396406. 3: Meurer K, Laniado M, Hosten N, Kelsch B, Hogstrom B. Intra-arterial and intravenous applications of Iosimenol 340 injection, a new non-ionic, dimeric, iso-osmolar radiographic contrast medium: phase 2 experience. Acta Radiol. 2015 Jun;56(6):702-8. doi: 10.1177/0284185114536157. Epub 2014 Jun 17. PubMed PMID: 24938661; PubMed Central PMCID: PMC4427611. 4: Zhang JJ, Morganroth J, Hogstrom B. Electrocardiographic response to intravenous and intraarterial injection of iosimenol (a new, iodinated, non-ionic, iso-osmolar contrast medium). J Invasive Cardiol. 2013 Nov;25(11):573-8. PubMed PMID: 24184891. 5: Sovak M, Terry R, Abramjuk C, Faberová V, Fiserova M, Laznicek M, Leuschner J, Malinak J, Zahradnik P, Masner O, Seligson A. Iosimenol, a low-viscosity nonionic dimer: preclinical physicochemistry, pharmacology, and pharmacokinetics. Invest Radiol. 2004 Mar;39(3):171-81. PubMed PMID: 15076009. 6: Fernandez Cabezudo MJ, Petroianu G, Al-Ramadi B, Langer RD. Iosimenol, a new non-ionic dimeric contrast medium, does not induce immunoreactivity in the popliteal lymph node assay. Br J Radiol. 2007 Sep;80(957):713-8. Epub 2007 Sep 3. PubMed PMID: 17768167. 7: Zhang JJ, Hogstrom B, Malinak J, Ikei N. Effects of viscosity on power and hand injection of iso-osmolar iodinated contrast media through thin catheters. Acta Radiol. 2016 May;57(5):557-64. doi: 10.1177/0284185115595059. Epub 2015 Jul 15. PubMed PMID: 26185266. 8: Böhm I, Schild HH. Induction of upregulation and downregulation of the T-cell activation marker CD98 in patients undergoing contrast-enhanced CT with iodinated non-ionic dimeric contrast medium. Korean J Radiol. 2009 Jan-Feb;10(1):58-62. doi: 10.3348/kjr.2009.10.1.58. PubMed PMID: 19182504; PubMed Central PMCID: PMC2647172. 9: Jost G, Lengsfeld P, Lenhard DC, Pietsch H, Hütter J, Sieber MA. Viscosity of iodinated contrast agents during renal excretion. Eur J Radiol. 2011 Nov;80(2):373-7. doi: 10.1016/j.ejrad.2011.02.003. Epub 2011 Mar 3. PubMed PMID: 21376497. 10: Clauss W, Scheller B, Schmitt A, Sovak M, Speck U. No difference among modern contrast media's effect on neointimal proliferation and restenosis after coronary stenting in pigs. Invest Radiol. 2003 Dec;38(12):743-9. PubMed PMID: 14627891. 11: Scheller B, Speck U, Schmitt A, Clauss W, Sovak M, Böhm M, Stoll HP. Acute cardiac tolerance of current contrast media and the new taxane protaxel using iopromide as carrier during porcine coronary angiography and stenting. Invest Radiol. 2002 Jan;37(1):29-34. PubMed PMID: 11753151.