Gea 857 | CAS#120493-42-7 | putative blocker of potassiu

MedKoo Cat#: 598101 | Name: Gea 857

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gea 857 is a putative blocker of potassium conductance.

Chemical Structure

Gea 857

CAS#120493-42-7

Theoretical Analysis

MedKoo Cat#: 598101

Name: Gea 857

CAS#: 120493-42-7

Chemical Formula: C15H22ClNO2

Exact Mass: 283.1339

Molecular Weight: 283.79

Elemental Analysis: C, 63.48; H, 7.81; Cl, 12.49; N, 4.94; O, 11.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Gea 857; Gea-857; Gea857;

IUPAC/Chemical Name

1-(4-chlorophenyl)-2-methylpropan-2-yl L-valinate

InChi Key

YKRSWMGPYKJOBF-ZDUSSCGKSA-N

InChi Code

InChI=1S/C15H22ClNO2/c1-10(2)13(17)14(18)19-15(3,4)9-11-5-7-12(16)8-6-11/h5-8,10,13H,9,17H2,1-4H3/t13-/m0/s1

SMILES Code

N[C@@H](C(C)C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 283.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hu PS, Ross SB. NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857. Pharmacol Toxicol. 1997 Feb;80(2):97-102. PubMed PMID: 9060041. 2: Ogren SO, Bartfai T, Hedlund B, Lindberg UH. GEA 857, a putative blocker of potassium conductance, enhances muscarinic agonist-evoked responses: dissociation from an action on 5-HT mechanisms. Pharmacol Toxicol. 1992 Aug;71(2):112-9. PubMed PMID: 1438027. 3: Hedlund B, Ogren SO. GEA 857 blocks potassium channels in the membrane and, thereby, prolongs muscarinic cholinergic responses in N1E-115 neuroblastoma cells. Pharmacol Toxicol. 1992 Aug;71(2):107-11. PubMed PMID: 1301072.