MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 575839 | Name: GE-2270 A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GE-2270 A inhibits bacterial protein synthesis in vitro via the GTP-bound form of elongation factor Tu.

Chemical Structure

GE-2270 A
GE-2270 A
CAS#134861-34-0

Theoretical Analysis

MedKoo Cat#: 575839

Name: GE-2270 A

CAS#: 134861-34-0

Chemical Formula: C56H55N15O10S6

Exact Mass: 1289.2581

Molecular Weight: 1290.51

Elemental Analysis: C, 52.12; H, 4.30; N, 16.28; O, 12.40; S, 14.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Antibiotic GE 2270A; GE 2270 A; GE2270 A; GE-2270 A; GE 2270; GE2270; GE-2270; MDL 62879; MDL62879; MDL-62879
IUPAC/Chemical Name
9H,16H-8,5:15,12:22,19:32,29:36,33-Pentanitrilo-5H,29H,33H-pyrido(3,2-a1)(1,11,18,25,31,4,7,14,21)pentathiatetraazacyclotetratriacontine-18-acetamide, 2-(4-(4-((2-(aminocarbonyl)-1-pyrrolidinyl)carbonyl)-4,5-dihydro-2-oxazolyl)-2-thiazolyl)-10,11,17,18,23,24,25,26,27,28-decahydro-28-(hydroxyphenylmethyl)-14-(methoxymethyl)-N,21-dimethyl-11-(1-methylethyl)-9,16,23,26-tetraoxo-
InChi Key
JMDULECOHIXMNX-MZHFYNGJSA-N
InChi Code
InChI=1S/C56H55N15O10S6/c1-24(2)39-55-70-42(36(87-55)19-80-5)47(77)59-17-38(73)67-43(44(74)26-10-7-6-8-11-26)54-66-34(23-85-54)52-63-31(20-83-52)41-27(50-64-32(21-82-50)46(76)61-29(16-37(72)58-4)53-69-40(25(3)86-53)48(78)68-39)13-14-28(60-41)51-65-33(22-84-51)49-62-30(18-81-49)56(79)71-15-9-12-35(71)45(57)75/h6-8,10-11,13-14,20-24,29-30,35,39,43-44,74H,9,12,15-19H2,1-5H3,(H2,57,75)(H,58,72)(H,59,77)(H,61,76)(H,67,73)(H,68,78)/t29-,30-,35-,39-,43-,44-/m0/s1
SMILES Code
CNC(=O)C[C@@H]1NC(=O)c2csc(n2)c3ccc(nc3c4csc(n4)c5csc(n5)[C@@H](NC(=O)CNC(=O)c6nc(sc6COC)[C@@H](NC(=O)c7nc1sc7C)C(C)C)[C@@H](O)c8ccccc8)c9nc(cs9)C%10=N[C@@H](CO%10)C(=O)N%11CCC[C@H]%11C(=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,290.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Heckmann G, Bach T. Synthesis of the heterocyclic core of the GE 2270 antibiotics and structure elucidation of a major degradation product. Angew Chem Int Ed Engl. 2005 Feb 11;44(8):1199-201. doi: 10.1002/anie.200461715. PMID: 15651011. 2. Prezioso SM, Brown NE, Goldberg JB. Elfamycins: inhibitors of elongation factor-Tu. Mol Microbiol. 2017 Oct;106(1):22-34. doi: 10.1111/mmi.13750. Epub 2017 Aug 9. PMID: 28710887; PMCID: PMC5701666.