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MedKoo Cat#: 598092 | Name: Soblidotin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Soblidotin is a dolastatin 10 derivative.

Chemical Structure

Soblidotin
Soblidotin
CAS#149606-27-9

Theoretical Analysis

MedKoo Cat#: 598092

Name: Soblidotin

CAS#: 149606-27-9

Chemical Formula: C39H67N5O6

Exact Mass: 701.5091

Molecular Weight: 701.99

Elemental Analysis: C, 66.73; H, 9.62; N, 9.98; O, 13.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Soblidotin; TZT-1027; TZT 1027; TZT1027;
IUPAC/Chemical Name
(S)-N-(dimethyl-L-valyl)-2-(((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(phenethylamino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methylbutanamide
InChi Key
WGTOWXLPARJQGY-ZBFGKEHZSA-N
InChi Code
InChI=1S/C39H67N5O6/c1-13-27(6)35(43(10)34(26(4)5)39(48)41-38(47)33(25(2)3)42(8)9)31(49-11)24-32(45)44-23-17-20-30(44)36(50-12)28(7)37(46)40-22-21-29-18-15-14-16-19-29/h14-16,18-19,25-28,30-31,33-36H,13,17,20-24H2,1-12H3,(H,40,46)(H,41,47,48)/t27-,28+,30-,31+,33-,34-,35-,36+/m0/s1
SMILES Code
CC(C)[C@@H](C(NC([C@H](C(C)C)N(C)C)=O)=O)N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(NCCC2=CC=CC=C2)=O)CCC1)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 701.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Watanabe J, Minami M, Kobayashi M. Antitumor activity of TZT-1027 (Soblidotin). Anticancer Res. 2006 May-Jun;26(3A):1973-81. PubMed PMID: 16827132. 2: Natsume T, Watanabe J, Horiuchi T, Kobayashi M. Combination effect of TZT-1027 (Soblidotin) with other anticancer drugs. Anticancer Res. 2006 Mar-Apr;26(2A):1145-51. PubMed PMID: 16619516. 3: Watanabe J, Natsume T, Kobayashi M. Antivascular effects of TZT-1027 (Soblidotin) on murine Colon26 adenocarcinoma. Cancer Sci. 2006 Dec;97(12):1410-6. Epub 2006 Sep 25. PubMed PMID: 16999818. 4: Watanabe J, Natsume T, Kobayashi M. Comparison of the antivascular and cytotoxic activities of TZT-1027 (Soblidotin) with those of other anticancer agents. Anticancer Drugs. 2007 Sep;18(8):905-11. PubMed PMID: 17667596. 5: Natsume T, Watanabe J, Ogawa K, Yasumura K, Kobayashi M. Tumor-specific antivascular effect of TZT-1027 (Soblidotin) elucidated by magnetic resonance imaging and confocal laser scanning microscopy. Cancer Sci. 2007 Apr;98(4):598-604. Epub 2007 Jan 31. PubMed PMID: 17284247. 6: Watanabe J, Endo Y, Shimada N, Natsume T, Sasaki T, Kobayashi M. Antiangiogenic activity of TZT-1027 (soblidotin) on chick chorioallantoic membrane and human umbilical vein endothelial cells. In Vivo. 2007 Mar-Apr;21(2):297-304. PubMed PMID: 17436580. 7: Natsume T, Watanabe J, Koh Y, Fujio N, Ohe Y, Horiuchi T, Saijo N, Nishio K, Kobayashi M. Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo. Cancer Sci. 2003 Sep;94(9):826-33. PubMed PMID: 12967483. 8: Watanabe J, Natsume T, Kobayashi M. The inhibitory effect of docetaxel and p38 MAPK inhibitor on TZT-1027 (Soblidotin)-induced antivascular activity. Anticancer Res. 2007 Nov-Dec;27(6B):3909-18. PubMed PMID: 18225550. 9: Shimoyama T, Hamano T, Natsume T, Koizumi F, Kiura K, Tanimoto M, Nishio K. Reference profiling of the genomic response induced by an antimicrotubule agent, TZT-1027 (Soblidotin), in vitro. Pharmacogenomics J. 2006 Nov-Dec;6(6):388-96. Epub 2006 Mar 21. PubMed PMID: 16550209. 10: Yan Q, Wang Y, Zhang W, Li Y. Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents. Mar Drugs. 2016 Apr 28;14(5). pii: E85. doi: 10.3390/md14050085. PubMed PMID: 27136567; PubMed Central PMCID: PMC4882559. 11: Doronina SO, Toki BE, Torgov MY, Mendelsohn BA, Cerveny CG, Chace DF, DeBlanc RL, Gearing RP, Bovee TD, Siegall CB, Francisco JA, Wahl AF, Meyer DL, Senter PD. Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat Biotechnol. 2003 Jul;21(7):778-84. Epub 2003 Jun 1. PubMed PMID: 12778055. 12: Fanale D, Bronte G, Passiglia F, Calò V, Castiglia M, Di Piazza F, Barraco N, Cangemi A, Catarella MT, Insalaco L, Listì A, Maragliano R, Massihnia D, Perez A, Toia F, Cicero G, Bazan V. Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option? Anal Cell Pathol (Amst). 2015;2015:690916. doi: 10.1155/2015/690916. Epub 2015 Sep 21. Review. PubMed PMID: 26484003; PubMed Central PMCID: PMC4592889. 13: Cormier A, Marchand M, Ravelli RB, Knossow M, Gigant B. Structural insight into the inhibition of tubulin by vinca domain peptide ligands. EMBO Rep. 2008 Nov;9(11):1101-6. doi: 10.1038/embor.2008.171. Epub 2008 Sep 12. PubMed PMID: 18787557; PubMed Central PMCID: PMC2581847. 14: Horti J, Juhasz E, Monostori Z, Maeda K, Eckhardt S, Bodrogi I. Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative, for the treatment of patients with non-small cell lung cancer. Cancer Chemother Pharmacol. 2008 Jun;62(1):173-80. doi: 10.1007/s00280-007-0665-7. Epub 2008 Jan 23. PubMed PMID: 18214483. 15: Cai YC, Zou Y, Xian LJ. [Advances in the study of the anti-tumor activity of small molecule vascular disrupting agents]. Yao Xue Xue Bao. 2010 Mar;45(3):283-8. Review. Chinese. PubMed PMID: 21351502. 16: Tamura K, Nakagawa K, Kurata T, Satoh T, Nogami T, Takeda K, Mitsuoka S, Yoshimura N, Kudoh S, Negoro S, Fukuoka M. Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, which was administered to patients with advanced solid tumors on days 1 and 8 in 3-week courses. Cancer Chemother Pharmacol. 2007 Jul;60(2):285-93. Epub 2006 Nov 30. PubMed PMID: 17136542. 17: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 May;29(4):303-11. PubMed PMID: 17609744. 18: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Jan-Feb;26(1):53-84. Review. PubMed PMID: 14988742. 19: Watanabe K, Tanimura S, Uchiyama A, Sakamoto T, Kawabata T, Ozaki K, Kohno M. Blockade of the extracellular signal-regulated kinase pathway enhances the therapeutic efficacy of microtubule-destabilizing agents in human tumor xenograft models. Clin Cancer Res. 2010 Feb 15;16(4):1170-8. doi: 10.1158/1078-0432.CCR-09-2482. Epub 2010 Feb 9. PubMed PMID: 20145173. 20: Hayakawa Y. [Structure-activity relationship analysis]. Gan To Kagaku Ryoho. 2004 Apr;31(4):526-8. Japanese. PubMed PMID: 15114695.

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