MedKoo Cat#: 563238 | Name: Methyl Streptonigrin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methyl Streptonigrin is an inhibitor of ABCG2 transporter function.

Chemical Structure

Methyl Streptonigrin
Methyl Streptonigrin
CAS#3398-48-9

Theoretical Analysis

MedKoo Cat#: 563238

Name: Methyl Streptonigrin

CAS#: 3398-48-9

Chemical Formula: C26H24N4O8

Exact Mass: 520.1594

Molecular Weight: 520.49

Elemental Analysis: C, 60.00; H, 4.65; N, 10.76; O, 24.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Methyl Streptonigrin; NSC-45384; NSC 45384; NSC45384;
IUPAC/Chemical Name
methyl 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinate
InChi Key
HKZHTIOXLTVSKR-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H24N4O8/c1-10-15(11-7-9-14(35-2)24(36-3)21(11)31)16(27)20(30-18(10)26(34)38-5)13-8-6-12-19(29-13)23(33)17(28)25(37-4)22(12)32/h6-9,31H,27-28H2,1-5H3
SMILES Code
COC1=C(OC)C=CC(C2=C(N)C(C3=NC4=C(C(C(OC)=C(N)C4=O)=O)C=C3)=NC(C(OC)=O)=C2C)=C1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 520.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 11962512. 11: Winski SL, Swann E, Hargreaves RH, Dehn DL, Butler J, Moody CJ, Ross D. Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones. Biochem Pharmacol. 2001 Jun 15;61(12):1509-16. PubMed PMID: 11377380. 12: Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P. Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo. Mol Pharmacol. 2000 Nov;58(5):1146-55. PubMed PMID: 11040064. 13: Winski SL, Hargreaves RH, Butler J, Ross D. A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. Clin Cancer Res. 1998 Dec;4(12):3083-8. PubMed PMID: 9865924. 14: Legault J, Tremblay A, Ramotar D, Mirault ME. 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