BJG-05-039 is a PAK1-selective degrader consisting of NVS-PAK1-1 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon. BJG-05-039 induced selective degradation of PAK1 and displayed enhanced antiproliferative effects relative to its parent compound in PAK1-dependent, but not PAK2-dependent, cell lines.
MedKoo Cat#: 122396
Name: BJG-05-039
CAS#: N/A
Chemical Formula: C41H44ClF3N8O5
Exact Mass: 820.3075
Molecular Weight: 821.30
Elemental Analysis: C, 59.96; H, 5.40; Cl, 4.32; F, 6.94; N, 13.64; O, 9.74
The following data is based on the product molecular weight 821.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
