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MedKoo Cat#: 592343 | Name: AK 275

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AK 275 is an inhibitor of calpain that prevents degradation of cytoskeletal and myelin proteins in spinal cord in vitro.

Chemical Structure

AK 275
AK 275
CAS#158798-83-5

Theoretical Analysis

MedKoo Cat#: 592343

Name: AK 275

CAS#: 158798-83-5

Chemical Formula: C20H31N3O4

Exact Mass: 377.2315

Molecular Weight: 377.49

Elemental Analysis: C, 63.64; H, 8.28; N, 11.13; O, 16.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AK-275; AK 275; AK275
IUPAC/Chemical Name
Butanamide, N-((phenylmethoxy)carbonyl)-L-leucyl-N-ethyl-L-2-amino-
InChi Key
STUAIIPUNIGTRM-DJNXLDHESA-N
InChi Code
InChI=1S/C20H31N3O4/c1-5-16(21)18(24)23(6-2)19(25)17(12-14(3)4)22-20(26)27-13-15-10-8-7-9-11-15/h7-11,14,16-17H,5-6,12-13,21H2,1-4H3,(H,22,26)/t16?,17-/m0/s1
SMILES Code
CCC(N)C(N(C([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)CC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 377.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: James T, Matzelle D, Bartus R, Hogan EL, Banik NL. New inhibitors of calpain prevent degradation of cytoskeletal and myelin proteins in spinal cord in vitro. J Neurosci Res. 1998 Jan 15;51(2):218-22. PubMed PMID: 9469575. 2: Zalewska T. Calpain as proposed target for neuroprotective treatment of brain ischemia. Folia Neuropathol. 1996;34(3):121-7. Review. PubMed PMID: 8946783. 3: Bartus RT, Baker KL, Heiser AD, Sawyer SD, Dean RL, Elliott PJ, Straub JA. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J Cereb Blood Flow Metab. 1994 Jul;14(4):537-44. PubMed PMID: 8014200.