NIBR-189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). NIBR-189 blocks migration of a monocyte cell line called U937, suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.
MedKoo Cat#: 522682
Name: NIBR-189
CAS#: 1599432-08-2
Chemical Formula: C21H21BrN2O3
Exact Mass: 428.0736
Molecular Weight: 429.31
Elemental Analysis: C, 58.75; H, 4.93; Br, 18.61; N, 6.53; O, 11.18
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 14.0 | 32.61 | ||
| DMF:PBS (pH 7.2) (1:8) | 0.1 | 0.23 | ||
| DMSO | 29.0 | 67.51 | ||
| Ethanol | 2.5 | 5.82 |
The following data is based on the product molecular weight 429.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
