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MedKoo Cat#: 563357 | Name: JWB1-84-1 3HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JWB1-84-1 3HCl is a neuroprotective agent that acts by improving cognitive performances in a transgenic mouse model of AD.

Chemical Structure

JWB1-84-1 3HCl
JWB1-84-1 3HCl
CAS#491878-69-4

Theoretical Analysis

MedKoo Cat#: 563357

Name: JWB1-84-1 3HCl

CAS#: 491878-69-4

Chemical Formula: C12H22Cl3N3O

Exact Mass:

Molecular Weight: 330.67

Elemental Analysis: C, 43.59; H, 6.71; Cl, 32.16; N, 12.71; O, 4.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
JWB1-84-1 3HCl; JWB1 84 1 3HCl; JWB1841 3HCl; JWB1-84-1 trihydrochloride; JWB1 84 1 trihydrochloride; JWB1841 trihydrochloride;
IUPAC/Chemical Name
2-(4-(pyridin-3-ylmethyl)piperazin-1-yl)ethan-1-ol trihydrochloride
InChi Key
UFVMFIXCHOTLGR-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H19N3O.3ClH/c16-9-8-14-4-6-15(7-5-14)11-12-2-1-3-13-10-12;;;/h1-3,10,16H,4-9,11H2;3*1H
SMILES Code
OCCN1CCN(CC2=CC=CN=C2)CC1.[H]Cl.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 330.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Keowkase R, Aboukhatwa M, Adam BL, Beach JW, Terry AV Jr, Buccafussco JJ, Luo Y. Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans. Mol Neurodegener. 2010 Dec 16;5:59. doi: 10.1186/1750-1326-5-59. PubMed PMID: 21162742; PubMed Central PMCID: PMC3017027. 2: Buccafusco JJ, Beach JW, Terry AV Jr. Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. J Pharmacol Exp Ther. 2009 Feb;328(2):364-70. doi: 10.1124/jpet.108.145292. Epub 2008 Nov 20. Review. PubMed PMID: 19023041; PubMed Central PMCID: PMC2682277. 3: Sood A, Warren Beach J, Webster SJ, Terry AV, Buccafusco JJ. The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys. Neuropharmacology. 2007 Oct;53(5):588-600. Epub 2007 Jul 14. PubMed PMID: 17698153. 4: Buccafusco JJ. Neuronal nicotinic receptor subtypes: defining therapeutic targets. Mol Interv. 2004 Oct;4(5):285-95. Review. PubMed PMID: 15471911.