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MedKoo Cat#: 463977 | Name: HCA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

(±)-Hydroxycitric acid (HCA) is a naturally occurring, chiral organic acid found predominantly in the rind of Garcinia cambogia fruit. It is best known for its potential anti-obesity effects, primarily through inhibition of ATP citrate lyase, an enzyme involved in the conversion of citrate to acetyl-CoA, thereby reducing de novo lipogenesis. The racemic mixture (±)-HCA includes both enantiomers, but the (-)-HCA is considered the biologically active form contributing to its metabolic effects.

Chemical Structure

HCA
HCA
CAS#6205-14-7

Theoretical Analysis

MedKoo Cat#: 463977

Name: HCA

CAS#: 6205-14-7

Chemical Formula: C6H8O8

Exact Mass: 208.0219

Molecular Weight: 208.12

Elemental Analysis: C, 34.63; H, 3.87; O, 61.50

Price and Availability

Size Price Availability Quantity
500mg USD 350.00 2 Weeks
1g USD 550.00 2 Weeks
5g USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
HCA; (±)-Hydroxycitric Acid; (±) Hydroxycitric Acid;
IUPAC/Chemical Name
1,2-dihydroxypropane-1,2,3-tricarboxylic acid
InChi Key
ZMJBYMUCKBYSCP-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H8O8/c7-2(8)1-6(14,5(12)13)3(9)4(10)11/h3,9,14H,1H2,(H,7,8)(H,10,11)(H,12,13)
SMILES Code
O=C(O)CC(C(O)C(O)=O)(O)C(O)=O
Appearance
Solid powder
Purity
>60% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
A hydroxy derivative of citric acid.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
Aqueous Acid 10.0 48.05
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 208.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: John OD, Mouatt P, Panchal SK, Brown L. Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats. Nutrients. 2021 Jan 22;13(2):319. doi: 10.3390/nu13020319. PMID: 33499382. 2: Bibyk MJ, Campbell MJ, Hummon AB. Mass-spectrometric investigations of caloric restriction mimetics. Proteomics. 2021 Jan 18:e2000121. doi: 10.1002/pmic.202000121. Epub ahead of print. PMID: 33460282. 3: Abdelhameed RM, Rocha J, Silva AMS. Selective separation of hibiscus acid from Roselle extracts by an amino-functionalized Metal Organic Framework. J Chromatogr A. 2021 Jan 11;1636:461789. doi: 10.1016/j.chroma.2020.461789. Epub 2020 Dec 8. PMID: 33326926. 4: Cruz AC, Pinto AHS, Costa CDD, Oliveira LP, Oliveira-Neto JR, Cunha LC. Food- Effect on (-) - Hydroxycitric Acid Absorption After Oral Administration of Garcinia cambogia Extract Formulation: a Phase I, Randomized, Cross-Over Study. J Pharm Sci. 2021 Feb;110(2):693-697. doi: 10.1016/j.xphs.2020.10.035. Epub 2020 Oct 24. PMID: 33164784. 5: Li L, Chu X, Yao Y, Cao J, Li Q, Ma H. (-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels. J Agric Food Chem. 2020 Oct 7;68(40):11229-11241. doi: 10.1021/acs.jafc.0c04648. Epub 2020 Sep 25. PMID: 32940033. 6: Ferreira V, Mathieu A, Soucy G, Giard JM, Erard-Poinsot D. Acute Severe Liver Injury Related to Long-Term Garcinia cambogia Intake. ACG Case Rep J. 2020 Aug 11;7(8):e00429. doi: 10.14309/crj.0000000000000429. PMID: 32821764; PMCID: PMC7423904. 7: Li M, Li X, Yang L. Cardioprotective effects of garcinol following myocardial infarction in rats with isoproterenol-induced heart failure. AMB Express. 2020 Aug 4;10(1):137. doi: 10.1186/s13568-020-01065-9. PMID: 32749545; PMCID: PMC7403263. 8: Baroni MD, Colombo S, Libens O, Pallavi R, Giorgio M, Martegani E. In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. Apoptosis. 2020 Oct;25(9-10):686-696. doi: 10.1007/s10495-020-01625-1. PMID: 32666259; PMCID: PMC7527365. 9: Fan QX, Gong SQ, Hong XZ, Feng XM, Zhang FJ. Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models. Eur Rev Med Pharmacol Sci. 2020 Jun;24(11):6434-6445. doi: 10.26355/eurrev_202006_21542. PMID: 32572941. 10: de Carvalho Cruz A, Suenaga EM, Prova SS, de Oliveira Neto JR, Ifa DR, da Cunha LC. New bioanalytical method for the quantification of (-) - hydroxycitric acid in human plasma using UPLC-MS/MS and its application in a Garcinia cambogia pharmacokinetic study. J Pharm Biomed Anal. 2020 Sep 5;188:113385. doi: 10.1016/j.jpba.2020.113385. Epub 2020 May 23. PMID: 32505893. 11: Ismail A, Doghish AS, E M Elsadek B, Salama SA, Mariee AD. Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase. Steroids. 2020 Aug;160:108656. doi: 10.1016/j.steroids.2020.108656. Epub 2020 May 18. PMID: 32439410. 12: Bhutani P, U R, H N S, Ranjanna PK, Paul AT. Rapid and cost-effective LC- MS/MS method for determination of hydroxycitric acid in plasma: Application in the determination of pharmacokinetics in commercial Garcinia preparations. Biomed Chromatogr. 2020 Oct;34(10):e4902. doi: 10.1002/bmc.4902. Epub 2020 Jun 11. PMID: 32428251. 13: Li L, Jiang Z, Yao Y, Yang Z, Ma H. (-)-Hydroxycitric acid regulates energy metabolism by activation of AMPK - PGC1α - NRF1 signal pathway in primary chicken hepatocytes. Life Sci. 2020 Aug 1;254:117785. doi: 10.1016/j.lfs.2020.117785. Epub 2020 May 13. PMID: 32416167. 14: Liu X, Yuan P, Sun X, Chen Z. Hydroxycitric Acid Inhibits Renal Calcium Oxalate Deposition by Reducing Oxidative Stress and Inflammation. Curr Mol Med. 2020;20(7):527-535. doi: 10.2174/1566524020666200103141116. PMID: 31902360. 15: Ibuki M, Shoda C, Miwa Y, Ishida A, Tsubota K, Kurihara T. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20):5049. doi: 10.3390/ijms20205049. PMID: 31614647; PMCID: PMC6834364. 16: Cho HK, Han YS, Park JM. Ocular complications of Garcinia cambogia extract diet pills: Case report. Eur J Ophthalmol. 2020 Nov;30(6):NP21-NP26. doi: 10.1177/1120672119872364. Epub 2019 Oct 3. PMID: 31578090. 17: Patel D, Buch A. Improvisation of a spectrophotometric method to quantify hydroxycitric acid. Anal Biochem. 2019 Dec 1;586:113412. doi: 10.1016/j.ab.2019.113412. Epub 2019 Aug 29. PMID: 31473244.

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