Synonym
Parabanic acid; NSC 9789; NSC-9789; NSC9789
IUPAC/Chemical Name
2,4,5-Imidazolidinetrione
InChi Key
ZFLIKDUSUDBGCD-UHFFFAOYSA-N
InChi Code
InChI=1S/C3H2N2O3/c6-1-2(7)5-3(8)4-1/h(H2,4,5,6,7,8)
SMILES Code
O=C1NC(C(N1)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
Parabanic acid is the singlet oxygen specific oxidation product of uric acid.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
114.06
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Iida S, Ohkubo Y, Yamamoto Y, Fujisawa A. Parabanic acid is the singlet oxygen specific oxidation product of uric acid. J Clin Biochem Nutr. 2017 Nov;61(3):169-175. doi: 10.3164/jcbn.17-24. Epub 2017 Sep 5. PubMed PMID: 29203957; PubMed Central PMCID: PMC5703782.
2: Dávalos JZ, Ribeiro da Silva Md, Ribeiro da Silva MA, Freitas VL, Jiménez P, Roux MV, Cabildo P, Claramunt RM, Elguero J. Computational thermochemistry of six ureas, imidazolidin-2-one, N,N'-trimethyleneurea, benzimidazolinone, parabanic acid, barbital (5,5'-diethylbarbituric acid), and 3,4,4'-trichlorocarbanilide, with an extension to related compounds. J Phys Chem A. 2010 Sep 2;114(34):9237-45. doi: 10.1021/jp103514f. PubMed PMID: 20681553.
3: Hudson MR, Allis DG, Hudson BS. The vibrational spectrum of parabanic acid by inelastic neutron scattering spectroscopy and simulation by solid-state DFT. J Phys Chem A. 2010 Mar 18;114(10):3630-41. doi: 10.1021/jp9114095. PubMed PMID: 20166734.
4: Hillered L, Persson L. Parabanic acid for monitoring of oxygen radical activity in the injured human brain. Neuroreport. 1995 Sep 11;6(13):1816-20. PubMed PMID: 8541489.
