Ethylparaben | CAS# 120-47-8 | antifungal preservative

MedKoo Cat#: 592154 | Name: Ethylparaben

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ethylparaben is used as an antifungal preservative.

Chemical Structure

Ethylparaben

CAS# 120-47-8

Theoretical Analysis

MedKoo Cat#: 592154

Name: Ethylparaben

CAS#: 120-47-8

Chemical Formula: C9H10O3

Exact Mass: 166.0630

Molecular Weight: 166.18

Elemental Analysis: C, 65.05; H, 6.07; O, 28.88

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 weeks
25g	USD 450.00	2 weeks

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Synonym

Ethylparaben; Ethyl 4-hydroxybenzoate; Ethyl paraben; Ethyl p-hydroxybenzoate; NSC 23514; NSC23514; NSC-23514

IUPAC/Chemical Name

Benzoic acid, 4-hydroxy-, ethyl ester

InChi Key

NUVBSKCKDOMJSU-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3

SMILES Code

O=C(OCC)C1=CC=C(O)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative. and food additive

In vitro activity:

BeWo cells were cultured with increasing concentrations of ethylparaben (0.1–10 mM); cell viability was, then, assessed at 24 and 48 h using the MTS assay. Ethylparaben treatment induced a significant decrease in cell viability in a dose- and time-dependent manner (Figure 1(A)). Reference: Anim Cells Syst (Seoul). 2020; 24(1): 34–43. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048193/

In vivo activity:

In order to examine the influence of chronic supplementation of 0.01% ethylparaben on SCF in murine bulbar conjunctivas (BCs), the present study investigated slices of murine eye specimens that underwent H&E staining. H&E staining demonstrated that the density of fibroblasts was mildly promoted and the deposition of collagen was tighter in the subepithelium of BCs in the experimental group than the control group (Fig. 1). These findings suggested that chronic supplementation of ethylparaben triggered bulbar subconjunctival fibrosis (BSF). Reference: Exp Ther Med. 2021 Apr; 21(4): 295. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885073/

	Solvent	mg/mL	mM
Solubility
	DMSO	66.5	400.17
	Ethanol	33.0	198.58

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 166.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Kim MJ, Kim CH, An MJ, Lee JH, Shin GS, Song M, Kim JW. Ethylparaben induces apoptotic cell death in human placenta BeWo cells via the Caspase-3 pathway. Anim Cells Syst (Seoul). 2020 Jan 9;24(1):34-43. doi: 10.1080/19768354.2020.1711804. PMID: 32158614; PMCID: PMC7048193. 2. Liu F, Kong X, Kong H. Ethylparaben induces subconjunctival fibrosis via the Wnt/β-catenin signaling pathway. Exp Ther Med. 2021 Apr;21(4):295. doi: 10.3892/etm.2021.9726. Epub 2021 Jan 28. PMID: 33717238; PMCID: PMC7885073.

In vitro protocol:

In vivo protocol:

1. Liu F, Kong X, Kong H. Ethylparaben induces subconjunctival fibrosis via the Wnt/β-catenin signaling pathway. Exp Ther Med. 2021 Apr;21(4):295. doi: 10.3892/etm.2021.9726. Epub 2021 Jan 28. PMID: 33717238; PMCID: PMC7885073.

1: Xue P, Zhao X, Qin M, Shi Z, Zhang M, Gu W. Transcriptome Analysis of Male Drosophila melanogaster Exposed to Ethylparaben Using Digital Gene Expression Profiling. J Insect Sci. 2017 Jul 1;17(4). doi: 10.1093/jisesa/iex050. PubMed PMID: 28973488; PubMed Central PMCID: PMC5510984. 2: Sun L, Yu T, Guo J, Zhang Z, Hu Y, Xiao X, Sun Y, Xiao H, Li J, Zhu D, Sai L, Li J. The estrogenicity of methylparaben and ethylparaben at doses close to the acceptable daily intake in immature Sprague-Dawley rats. Sci Rep. 2016 Apr 28;6:25173. doi: 10.1038/srep25173. PubMed PMID: 27121550; PubMed Central PMCID: PMC4848538. 3: Zúñiga-Benítez H, Peñuela GA. Degradation of ethylparaben under simulated sunlight using photo-Fenton. Water Sci Technol. 2016;73(4):818-26. doi: 10.2166/wst.2015.493. PubMed PMID: 26901724. 4: Jianmei C, Bo L, Zheng C, Huai S, Guohong L, Cibin G. Identification of ethylparaben as the antimicrobial substance produced by Brevibacillus brevis FJAT-0809-GLX. Microbiol Res. 2015 Mar;172:48-56. doi: 10.1016/j.micres.2014.11.007. Epub 2014 Dec 5. PubMed PMID: 25542595. 5: Liu T, Li Y, Zhao X, Zhang M, Gu W. Ethylparaben affects lifespan, fecundity, and the expression levels of ERR, EcR and YPR in Drosophila melanogaster. J Insect Physiol. 2014 Dec;71:1-7. doi: 10.1016/j.jinsphys.2014.09.008. Epub 2014 Sep 27. PubMed PMID: 25265034. 6: Zhao X, Li Y, Gu W. [Reproductive toxicity of ethylparaben on male Drosophila melanogaster]. Wei Sheng Yan Jiu. 2014 Mar;43(2):265-70. Chinese. PubMed PMID: 24868981. 7: Shabir GA. A New Validated HPLC Method for the Simultaneous Determination of 2-phenoxyethanol, Methylparaben, Ethylparaben and Propylparaben in a Pharmaceutical Gel. Indian J Pharm Sci. 2010 Jul;72(4):421-5. doi: 10.4103/0250-474X.73906. PubMed PMID: 21218050; PubMed Central PMCID: PMC3013559. 8: Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. Int J Toxicol. 2008;27 Suppl 4:1-82. doi: 10.1080/10915810802548359. PubMed PMID: 19101832. 9: Liu SQ, Zhang YQ, Zhang JB, Gao GE, Gu XQ. [Simultaneous determination of fluorouracilum and ethylparaben in polyphase liposomes using Kalman filtering spectrophotometry]. Yao Xue Xue Bao. 1988 Jun;23(6):435-40. Chinese. PubMed PMID: 3213529. 10: Goto A, Endo F, Higashino T. Gel filtration of solubilized systems. VII. Temperature effect on the solubilization of ethylparaben in hexaoxyethylene lauryl ether micelles. Chem Pharm Bull (Tokyo). 1984 Aug;32(8):2905-9. PubMed PMID: 6518577. 11: Simpson M, Parrott EL. Dissolution kinetics of a three-component solid I: ethylparaben, phenacetin, and salicylamide. J Pharm Sci. 1983 Jul;72(7):757-64. PubMed PMID: 6886981.