MedKoo Cat#: 461047 | Name: Morazone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Morazone is a nonsteroidal anti-inflammatory drug which is used as an analgesic. It produces phenmetrazine as a major metabolite and has been reported to have been abused as a recreational drug in the past.

Chemical Structure

Morazone
Morazone
CAS#6536-18-1

Theoretical Analysis

MedKoo Cat#: 461047

Name: Morazone

CAS#: 6536-18-1

Chemical Formula: C23H27N3O2

Exact Mass: 377.2103

Molecular Weight: 377.49

Elemental Analysis: C, 73.18; H, 7.21; N, 11.13; O, 8.48

Price and Availability

Size Price Availability Quantity
10mg USD 340.00 2 Weeks
100mg USD 1,730.00 2 Weeks
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Related CAS #
No Data
Synonym
Morazone; NSC 292156; NSC-292156; NSC292156; Orsimon; R 445; R-445; R445;
IUPAC/Chemical Name
1,5-dimethyl-4-((3-methyl-2-phenylmorpholino)methyl)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
InChi Key
OOGNFQMTGRZRAB-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H27N3O2/c1-17-21(23(27)26(24(17)3)20-12-8-5-9-13-20)16-25-14-15-28-22(18(25)2)19-10-6-4-7-11-19/h4-13,18,22H,14-16H2,1-3H3
SMILES Code
O=C1C(CN2C(C)C(C3=CC=CC=C3)OCC2)=C(C)N(C)N1C4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Biological target:
Morazone is a nonsteroidal anti-inflammatory drug which is used as an analgesic.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 377.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Lho D, Shin H, Park J. Simultaneous determination of morazone and phenmetrazine in rat plasma and urine using an on-column injection technique with fused-silica capillary column gas chromatography. J Anal Toxicol. 1990 Mar-Apr;14(2):113-5. PubMed PMID: 1969972. 2: Neugebauer M. Some new urinary metabolites of famprofazone and morazone in man. J Pharm Biomed Anal. 1984;2(1):53-60. PubMed PMID: 16867765. 3: Kingreen JC, Breger G. [Pellagra in morazone abuse]. Z Hautkr. 1984 May 1;59(9):573-7. German. PubMed PMID: 6145264. 4: Bohn G, Rücker G, Kröger H. [Investigations of the decomposition and detection of morazone by thin-layer- and gas-liquid-chromatography]. Arch Toxicol. 1976 Jun 8;35(3):213-20. German. PubMed PMID: 989292. 5: Cui JF, Zhou Y, Cui KR, Li L, Zhou TH. [Study on metabolism of phenmetrazine-like drugs and their metabolites]. Yao Xue Xue Bao. 1990;25(8):632-6. Chinese. PubMed PMID: 1982038. 6: Marciniec B. Photochemical decomposition of phenazone derivatives. Part 5(1): Isolation and identification of decomposition products in aqueous solution. Pharmazie. 1985 Jan;40(1):30-3. PubMed PMID: 3991782. 7: Marciniec B. Photochemical decomposition of phenazone derivatives. Part 6: Effect of substituents on mass fragmentation and photochemical stability. Pharmazie. 1985 Feb;40(2):110-2. PubMed PMID: 4001143. 8: Keup W. Use, indications and distribution in different countries of the stimulant and hallucinogenic amphetamine derivatives under consideration by WHO. Drug Alcohol Depend. 1986 Jun;17(2-3):169-92. PubMed PMID: 2874968.