CL67 | CAS#1401242-86-1 | hypoxia inhibitor

MedKoo Cat#: 563341 | Name: CL67

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CL67 is an inhibitor of the hypoxia-inducible factor pathway. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.

Chemical Structure

CL67

CAS#1401242-86-1

Theoretical Analysis

MedKoo Cat#: 563341

Name: CL67

CAS#: 1401242-86-1

Chemical Formula: C38H42N10O2

Exact Mass: 670.3492

Molecular Weight: 670.82

Elemental Analysis: C, 68.04; H, 6.31; N, 20.88; O, 4.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

CL67; CL-67; CL 67;

IUPAC/Chemical Name

N,N'-((naphthalene-2,7-diylbis(1H-1,2,3-triazole-4,1-diyl))bis(3,1-phenylene))bis(2-(diethylamino)acetamide)

InChi Key

WXTDHADVBWQHLW-UHFFFAOYSA-N

InChi Code

InChI=1S/C38H42N10O2/c1-5-45(6-2)25-37(49)39-31-11-9-13-33(21-31)47-23-35(41-43-47)28-17-15-27-16-18-29(20-30(27)19-28)36-24-48(44-42-36)34-14-10-12-32(22-34)40-38(50)26-46(7-3)8-4/h9-24H,5-8,25-26H2,1-4H3,(H,39,49)(H,40,50)

SMILES Code

O=C(CN(CC)CC)NC1=CC(N2N=NC(C3=CC4=C(C=C3)C=CC(C5=CN(C6=CC(NC(CN(CC)CC)=O)=CC=C6)N=N5)=C4)=C2)=CC=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 670.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Welsh SJ, Dale AG, Lombardo CM, Valentine H, de la Fuente M, Schatzlein A, Neidle S. Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule. Sci Rep. 2013 Sep 30;3:2799. doi: 10.1038/srep02799. PubMed PMID: 24165797; PubMed Central PMCID: PMC3810677. 2: Ellenberg P, Edreira M, Lozano M, Scolaro L. Synthesis and expression of viral antigens in Vero cells persistently infected with Junin virus. Arch Virol. 2002 Aug;147(8):1543-57. PubMed PMID: 12181674. 3: Scolaro LA, Damonte EB. Glycoprotein-mediated biological properties of a host range mutant of Junin virus. Res Virol. 1997 Sep-Oct;148(5):323-31. PubMed PMID: 9403931. 4: Scolaro LA, Mersich SE, Damonte EB. Experimental infection of suckling mice with a host range mutant of Junin virus. J Med Virol. 1991 Aug;34(4):237-40. PubMed PMID: 1658215.