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MedKoo Cat#: 461038 | Name: Clometacin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clometacin is a nonsteroidal anti-inflammatory drug.

Chemical Structure

Clometacin
Clometacin
CAS#25803-14-9

Theoretical Analysis

MedKoo Cat#: 461038

Name: Clometacin

CAS#: 25803-14-9

Chemical Formula: C19H16ClNO4

Exact Mass: 357.0768

Molecular Weight: 357.79

Elemental Analysis: C, 63.78; H, 4.51; Cl, 9.91; N, 3.91; O, 17.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Clometacin; C 1656; C-1656; C1656; Duperan; R 3959; R-3959; R3959; RU 3959; RU-3959; RU3959;
IUPAC/Chemical Name
2-(3-(4-chlorobenzoyl)-6-methoxy-2-methyl-1H-indol-1-yl)acetic acid
InChi Key
DGMZLCLHHVYDIS-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H16ClNO4/c1-11-18(19(24)12-3-5-13(20)6-4-12)15-8-7-14(25-2)9-16(15)21(11)10-17(22)23/h3-9H,10H2,1-2H3,(H,22,23)
SMILES Code
CC1=C(C(c2ccc(Cl)cc2)=O)c3c(N1CC(O)=O)cc(OC)cc3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zini R, Barre J, D'Athis P, Tillement JP. Binding of clometacin to human serum albumin. Interactions with clofibrate, indomethacin, salicylic acid and warfarin. Biochem Pharmacol. 1983 Oct 1;32(19):2909-14. PubMed PMID: 6626262. 2: Pariente EA, Hamoud A, Goldfain D, Latrive JP, Gislon J, Cassan P, Morin T, Staub JL, Ramain JP, Bertrand JL, et al. [Hepatitis caused by clometacin (Dupéran). Retrospective study of 30 cases. A model of autoimmune drug-induced hepatitis?]. Gastroenterol Clin Biol. 1989 Oct;13(10):769-74. Review. French. PubMed PMID: 2687071. 3: Van Cantfort J, De Graeve J, Hercelin B, Gielen JE. [Clometacin--1. Metabolism and bioavailability of clometacin and its metabolites in the rat]. J Pharm Belg. 1982 Nov-Dec;37(6):401-9. French. PubMed PMID: 7161699. 4: Deray G, Baumelou A, Hornych A, Merdjan H, de Groc F. Acute effects of clometacin on renal prostaglandin biosynthesis in healthy subjects. Eur J Clin Pharmacol. 1986;30(4):499-501. PubMed PMID: 3091372. 5: Andrieu J, Doll J, Gardon JD, Rambaud S. [Hepatitis caused by clometacin and asymptomatic primary biliary cirrhosis]. Ann Gastroenterol Hepatol (Paris). 1989 Nov;25(6):259-60. French. PubMed PMID: 2619254. 6: Siproudhis L, Beaugrand M, Malledant Y, Brissot P, Guguen-Guillouzo C, Guillouzo A. Use of adult human hepatocytes in primary culture for the study of clometacin-induced immunoallergic hepatitis. Toxicol In Vitro. 1991;5(5-6):529-34. PubMed PMID: 20732071. 7: Fournier PE, Muzard D. [Clometacin]. Nouv Presse Med. 1981 May 9;10(21):1748-9. French. PubMed PMID: 7232165. 8: Islam S, Mekhloufi F, Paul JM, Islam M, Johanet C, Legendre C, Degott C, Abuaf N, Homberg JC. Characteristics of clometacin-induced hepatitis with special reference to the presence of anti-actin cable antibodies. Autoimmunity. 1989;2(3):213-21. PubMed PMID: 2491606. 9: Clerc D, Delfraissy JF, Sallière D, Ramain C, Bisson M, Massias P. [Acute renal insufficiency with ketoprofen and clometacin]. Sem Hop. 1983 May 26;59(21):1613-5. French. PubMed PMID: 6310774. 10: Elbaz JS, Bernard A. A controlled repeat-dose comparison of zomepirac and clometacin in pain after plastic surgery. J Clin Pharmacol. 1980 Apr;20(4):303-8. PubMed PMID: 6991549. 11: Chagnon JP, Barge J. [Clometacin-induced chronic active hepatitis and HLA-B8 antigen]. Gastroenterol Clin Biol. 1983 May;7(5):556. French. PubMed PMID: 6603383. 12: Hercelin B, Mary I, Nung VN, Drouet A, Devissaguet JP. [Clometacin. 5. Pharmacokinetic study of a fast-acting form in man]. J Pharm Belg. 1985 May-Jun;40(3):159-62. French. PubMed PMID: 4032212. 13: Monegier Du Sorbier H, Canault Y, Barbarin Y. [Acute thrombopenic purpura : responsibility of clometacin]. Nouv Presse Med. 1980 Feb 9;9(7):458. French. PubMed PMID: 7189056. 14: Van Cantfort J, Mary I, Gielen JE. [Clometacin--2. Metabolism and bioavailability in the monkey and in man]. J Pharm Belg. 1982 Nov-Dec;37(6):410-7. French. PubMed PMID: 7161700. 15: Edou D, Godin M, Colonna L, Petit M, Fillastre JP. [Drug interaction: clometacin-lithium]. Presse Med. 1983 Jun 4;12(24):1551. French. PubMed PMID: 6222369. 16: Lavaud S, Mamez B, Lavaud F, Birembaut P, Toupance O, Brunois JP, Chanard J. [Acute renal failure caused by clometacin hypersensitivity]. Nephrologie. 1984;5(3):131-4. French. PubMed PMID: 6493431. 17: Spreux A, Larousse C. [Clometacin hepatitis collected by pharmacovigilance hospital centers (author's transl)]. Therapie. 1981 May-Jun;36(3):293-7. French. PubMed PMID: 7292407. 18: Bars L, Beaugrand M, Callard P, Ferrier JP. [Another histological aspect of hepatitis caused by clometacin]. Gastroenterol Clin Biol. 1981 Nov;5(11):1064-5. French. PubMed PMID: 7308680. 19: Andrejak M, Makdassi R, Fievet P, Coevoet B, Lambrey G, Bataille P, Sebert JL, Fournier A. [Renal toxicity of nonsteroidal anti-inflammatory agents and clometacin]. Therapie. 1986 Sep-Oct;41(5):331-7. French. PubMed PMID: 3810520. 20: Jacquot C, Hornych A, d'Auzac de la Martinie C, Bariéty J. [Acute renal insufficiency caused by clometacin. Relapse with diclofenac. Inhibition of the synthesis of prostaglandins]. Rev Med Interne. 1982 Dec;3(4):349-51. French. PubMed PMID: 7163673.

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