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MedKoo Cat#: 597613 | Name: Senktide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM).1,2,3 It less potently agonizes the NK1 receptor (EC50 = 35 µM) and is without effect on the NK2 receptor. Senktide is used to study the action of the NK3 receptor in cells and in animals.

Chemical Structure

Senktide
CAS#106128-89-6

Theoretical Analysis

MedKoo Cat#: 597613

Name: Senktide

CAS#: 106128-89-6

Chemical Formula: C40H55N7O11S

Exact Mass: 841.3680

Molecular Weight: 841.98

Elemental Analysis: C, 57.06; H, 6.58; N, 11.65; O, 20.90; S, 3.81

Price and Availability

Size Price Availability Quantity
1mg USD 400.00
5mg USD 900.00
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Related CAS #
No Data
Synonym
Senktide;
IUPAC/Chemical Name
(5S,8S,14S,17S,20S)-14,17-dibenzyl-5-carbamoyl-20-(carboxymethyl)-8-isobutyl-15-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazapentacosan-25-oic acid
InChi Key
HMHYXLVEFVGOPM-QKUYTOGTSA-N
InChi Code
InChI=1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1
SMILES Code
CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CC=CC=C1)N(C([C@H](CC2=CC=CC=C2)NC([C@H](CC(O)=O)NC(CCC(O)=O)=O)=O)=O)C)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Senktide is a potent, selective agonist of the NK3 receptor (EC50 = 0.5-3 nM). It less potently agonizes the NK1 receptor (EC50 = 35 µM) and is without effect on the NK2 receptor.
In vitro activity:
Long-term senktide treatment resulted in a decrease in GnRH secretion in GT1-7 cells. Results indicated that senktide repressed GnRH transcription through enhanced c-Fos protein binding at activator protein-1 half-sites in enhancer 1 and the promoter. These findings suggest that NKB's direct impact on NK3R-expressing GnRH neurons may have dual effects on GnRH secretion, depending on the duration of exposure and its influence on transcriptional regulation. Reference: Mol Endocrinol. 2013 Mar;27(3):437-54. https://pubmed.ncbi.nlm.nih.gov/23393128/
In vivo activity:
Senktide decreased the core body temperature of Japanese Black cattle, which has potential use in counteracting heat stress, which disrupts reproductive function in cattle. In both summer and winter, continuous infusion of senktide for 4 hours immediately decreased vaginal temperature. These findings provide new therapeutic options for senktide to support both heat-defense responses and GnRH/LH pulse generation. Reference: Domest Anim Endocrinol. 2021 Jan;74:106522. https://pubmed.ncbi.nlm.nih.gov/32841888/
Solvent mg/mL mM comments
Solubility
DMSO 50.0 59.38
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 841.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Glidewell-Kenney CA, Shao PP, Iyer AK, Grove AM, Meadows JD, Mellon PL. Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol. 2013 Mar;27(3):437-54. doi: 10.1210/me.2012-1271. Epub 2013 Feb 7. PMID: 23393128; PMCID: PMC3589675. 2. Keegan KD, Woodruff GN, Pinnock RD. The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br J Pharmacol. 1992 Jan;105(1):3-5. doi: 10.1111/j.1476-5381.1992.tb14199.x. PMID: 1375857; PMCID: PMC1908621. 3. Nakamura S, Miwa M, Morita Y, Ohkura S, Yamamura T, Wakabayashi Y, Matsuyama S. Neurokinin 3 receptor-selective agonist, senktide, decreases core temperature in Japanese Black cattle. Domest Anim Endocrinol. 2021 Jan;74:106522. doi: 10.1016/j.domaniend.2020.106522. Epub 2020 Jul 28. PMID: 32841888. 4. Nordquist RE, Durkin S, Jacquet A, Spooren W. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. doi: 10.1016/j.ejphar.2008.10.011. Epub 2008 Oct 10. PMID: 18930726.
In vitro protocol:
1. Glidewell-Kenney CA, Shao PP, Iyer AK, Grove AM, Meadows JD, Mellon PL. Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol. 2013 Mar;27(3):437-54. doi: 10.1210/me.2012-1271. Epub 2013 Feb 7. PMID: 23393128; PMCID: PMC3589675. 2. Keegan KD, Woodruff GN, Pinnock RD. The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br J Pharmacol. 1992 Jan;105(1):3-5. doi: 10.1111/j.1476-5381.1992.tb14199.x. PMID: 1375857; PMCID: PMC1908621.
In vivo protocol:
1. Nakamura S, Miwa M, Morita Y, Ohkura S, Yamamura T, Wakabayashi Y, Matsuyama S. Neurokinin 3 receptor-selective agonist, senktide, decreases core temperature in Japanese Black cattle. Domest Anim Endocrinol. 2021 Jan;74:106522. doi: 10.1016/j.domaniend.2020.106522. Epub 2020 Jul 28. PMID: 32841888. 2. Nordquist RE, Durkin S, Jacquet A, Spooren W. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. doi: 10.1016/j.ejphar.2008.10.011. Epub 2008 Oct 10. PMID: 18930726.
1: Ivanova D, Voliotis M, Tsaneva-Atanasova K, O'Byrne KT, Li XF. NK3R signalling in the posterodorsal medial amygdala is involved in stress-induced suppression of pulsatile LH secretion in female mice. J Neuroendocrinol. 2024 May;36(5):e13384. doi: 10.1111/jne.13384. Epub 2024 Mar 22. PMID: 38516965; PMCID: PMC11411622. 2: Ramzan MH, Shah M, Ramzan F. Neurokinin B Administration Induces Dose Dependent Proliferation of Seminal Vesicles in Adult Rats. Curr Protein Pept Sci. 2024;25(4):339-352. doi: 10.2174/0113892037264538231128072614. PMID: 38243941. 3: Huang HZ, Ai WQ, Wei N, Zhu LS, Liu ZQ, Zhou CW, Deng MF, Zhang WT, Zhang JC, Yang CQ, Hu YZ, Han ZT, Zhang HH, Jia JJ, Wang J, Liu FF, Li K, Xu Q, Yuan M, Man H, Guo Z, Lu Y, Shu K, Zhu LQ, Liu D. Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice. Protein Cell. 2024 Apr 1;15(4):261-284. doi: 10.1093/procel/pwad056. PMID: 38011644; PMCID: PMC10984625. 4: Aerts EG, Griesgraber MJ, Shuping SL, Bowdridge EC, Hardy SL, Goodman RL, Nestor CC, Hileman SM. The effect of NK3-Saporin injection within the arcuate nucleus on puberty, the LH surge, and the response to Senktide in female sheep†. Biol Reprod. 2024 Feb 10;110(2):275-287. doi: 10.1093/biolre/ioad147. PMID: 37930247. 5: Wiedmann F, Paasche A, Nietfeld J, Kraft M, Meyer AL, Warnecke G, Karck M, Frey N, Schmidt C. Activation of neurokinin-III receptors modulates human atrial TASK-1 currents. J Mol Cell Cardiol. 2023 Nov;184:26-36. doi: 10.1016/j.yjmcc.2023.09.010. Epub 2023 Oct 2. PMID: 37793594. 6: Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C. Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discov. 2023 Jun 30;9(1):66. doi: 10.1038/s41421-023-00564-w. PMID: 37391393; PMCID: PMC10313662. 7: Yamamura T, Okamura H, Wakabayashi Y. Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats. J Reprod Dev. 2023 Aug 11;69(4):218-222. doi: 10.1262/jrd.2023-025. Epub 2023 Jun 4. PMID: 37271516; PMCID: PMC10435531. 8: Matsuyama S, Nakamura S, Minabe S, Ohkura S, Kimura K. Effect of a neurokinin 3 receptor-selective agonist administration on the embryos recovered from superovulated cows. Biol Reprod. 2023 Jun 9;108(6):936-944. doi: 10.1093/biolre/ioad039. PMID: 37074152. 9: Koca RO, Gormus ZIS, Solak H, Koc A, Kılınc İ, İyisoy MS, Kutlu S. How does neurokinin 3 receptor agonism affect pathological and cognitive impairments in an Alzheimer's disease-like rat model? Amino Acids. 2023 Apr;55(4):481-498. doi: 10.1007/s00726-023-03241-0. Epub 2023 Feb 6. PMID: 36745246. 10: Boyle CA, Hu B, Quaintance KL, Mastrud MR, Lei S. Ionic signalling mechanisms involved in neurokinin-3 receptor-mediated augmentation of fear- potentiated startle response in the basolateral amygdala. J Physiol. 2022 Oct;600(19):4325-4345. doi: 10.1113/JP283433. Epub 2022 Sep 13. PMID: 36030507; PMCID: PMC9529888. 11: Hibberd TJ, Costa M, Smolilo DJ, Keightley LJ, Brookes SJ, Dinning PG, Spencer NJ. Mechanisms underlying initiation of propulsion in guinea pig distal colon. Am J Physiol Gastrointest Liver Physiol. 2022 Aug 1;323(2):G71-G87. doi: 10.1152/ajpgi.00055.2022. Epub 2022 May 3. PMID: 35502864. 12: Leon S, Talbi R, McCarthy EA, Ferrari K, Fergani C, Naule L, Choi JH, Carroll RS, Kaiser UB, Aylwin CF, Lomniczi A, Navarro VM. Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2. Elife. 2021 Sep 8;10:e69765. doi: 10.7554/eLife.69765. PMID: 34494548; PMCID: PMC8439651. 13: Talbi R, Ferrari K, Choi JH, Gerutshang A, McCarthy EA, Dischino D, León S, Navarro VM. Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice. Endocrinology. 2021 Aug 1;162(8):bqab074. doi: 10.1210/endocr/bqab074. Erratum in: Endocrinology. 2021 Oct 1;162(10):bqab146. doi: 10.1210/endocr/bqab146. PMID: 33839770; PMCID: PMC8234505. 14: Fleischer AW, Schalk JC, Wetzel EA, Hanson AM, Sem DS, Donaldson WA, Frick KM. Long-term oral administration of a novel estrogen receptor beta agonist enhances memory and alleviates drug-induced vasodilation in young ovariectomized mice. Horm Behav. 2021 Apr;130:104948. doi: 10.1016/j.yhbeh.2021.104948. Epub 2021 Mar 8. PMID: 33571507; PMCID: PMC8680219. 15: Nakamura S, Miwa M, Morita Y, Ohkura S, Yamamura T, Wakabayashi Y, Matsuyama S. Neurokinin 3 receptor-selective agonist, senktide, decreases core temperature in Japanese Black cattle. Domest Anim Endocrinol. 2021 Jan;74:106522. doi: 10.1016/j.domaniend.2020.106522. Epub 2020 Jul 28. PMID: 32841888. 16: Lopez JA, Bowdridge EC, McCosh RB, Bedenbaugh MN, Lindo AN, Metzger M, Haller M, Lehman MN, Hileman SM, Goodman RL. Morphological and functional evidence for sexual dimorphism in neurokinin B signalling in the retrochiasmatic area of sheep. J Neuroendocrinol. 2020 Jul;32(7):e12877. doi: 10.1111/jne.12877. Epub 2020 Jun 22. PMID: 32572994; PMCID: PMC7449597. 17: Amodei R, Gribbin K, He W, Lindgren I, Corder KR, Jonker SS, Estill CT, Coolen LM, Lehman MN, Whitler W, Stormshak F, Roselli CE. Role for Kisspeptin and Neurokinin B in Regulation of Luteinizing Hormone and Testosterone Secretion in the Fetal Sheep. Endocrinology. 2020 Apr 1;161(4):bqaa013. doi: 10.1210/endocr/bqaa013. PMID: 32005991; PMCID: PMC7079722. 18: Garcia JP, Keen KL, Seminara SB, Terasawa E. Role of Kisspeptin and NKB in Puberty in Nonhuman Primates: Sex Differences. Semin Reprod Med. 2019 Mar;37(2):47-55. doi: 10.1055/s-0039-3400253. Epub 2019 Dec 17. PMID: 31847024; PMCID: PMC7055930. 19: Dees WL, Hiney JK, Srivastava VK. Regulation of prepubertal dynorphin secretion in the medial basal hypothalamus of the female rat. J Neuroendocrinol. 2019 Dec;31(12):e12810. doi: 10.1111/jne.12810. PMID: 31715027; PMCID: PMC6916394. 20: Mizrahi N, Gilon C, Atre I, Ogawa S, Parhar IS, Levavi-Sivan B. Deciphering Direct and Indirect Effects of Neurokinin B and GnRH in the Brain-Pituitary Axis of Tilapia. Front Endocrinol (Lausanne). 2019 Jul 12;10:469. doi: 10.3389/fendo.2019.00469. PMID: 31354632; PMCID: PMC6639853.