Synonym
R 29814; R-29814; R29814; R 28935; R-28935; R28935;
IUPAC/Chemical Name
1-(1-((2S)-2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-2-hydroxyethyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
InChi Key
ZBPOBVZNVTZLGP-YMXDCFFPSA-N
InChi Code
InChI=1S/C22H25N3O4/c26-18(21-14-28-19-7-3-4-8-20(19)29-21)13-24-11-9-15(10-12-24)25-17-6-2-1-5-16(17)23-22(25)27/h1-8,15,18,21,26H,9-14H2,(H,23,27)/t18-,21?/m0/s1
SMILES Code
O[C@H](C1COc2c(O1)cccc2)CN3CCC(N4C(Nc5c4cccc5)=O)CC3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
395.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Timmermans PB, Harms YM, Batink HD, Van Zwieten PA. Specific binding of threo 1-(1-[2-(1,4-benzodioxane-2-yl)-2-hydroxyethyl]4-piperidyl)-2-benzimidazolinone (R 29814), to rat brain membranes. Neuropharmacology. 1982 Oct;21(10):1039-43. PubMed PMID: 7145033.
2: Timmermans PB, Van Zwieten PA. Centrally induced impairment of the hypotensive effects of R 28935 and R 29814 by prazosin in anaesthetized cats. Eur J Pharmacol. 1980 Feb;61(4):385-8. PubMed PMID: 7053064.
3: Kwa HY, Timmermans PB, Van Zwieten PA. Interaction between prazosin and benzodioxan antihypertensives (R 28935 and R 29814); a competition for central alpha 1-adrenoceptors [proceedings]. Br J Pharmacol. 1980 Jan;68(1):138P-139P. PubMed PMID: 6244026; PubMed Central PMCID: PMC2044080.
4: Timmermans PB, Slothorst-Grisdijk FP, Kwa HY, van Zwieten PA. Inhibition of R 28935- and R 29814-induced hypotension by prazosin in anaesthetized normotensive rats. Arch Int Pharmacodyn Ther. 1982 Feb;255(2):309-20. PubMed PMID: 7073408.
5: Timmermans PB, Harms YM, Batink HD, van Zwieten PA. Analysis of the displaceable binding of the hypotensive drug R 28935 in rat brain. Biochem Pharmacol. 1982 Dec 1;31(23):3933-6. PubMed PMID: 7159472.
6: Frisk-Holmberg M. Effect of clonidine at steady state on blood pressure in spontaneously hypertensive rats. Interaction of various alpha-adrenoceptor antagonists. Acta Physiol Scand. 1984 Jan;120(1):37-42. PubMed PMID: 6144238.
7: Doods HN, Boddeke HW, Kalkman HO, Hoyer D, Mathy MJ, van Zwieten PA. Central 5-HT1A receptors and the mechanism of the central hypotensive effect of (+)8-OH-DPAT, DP-5-CT, R28935, and urapidil. J Cardiovasc Pharmacol. 1988 Apr;11(4):432-7. PubMed PMID: 2453746.
