MedKoo Cat#: 592257 | Name: Aminohippuric acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aminohippuric acid is the glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.

Chemical Structure

Aminohippuric acid
Aminohippuric acid
CAS#61-78-9 (free acid)

Theoretical Analysis

MedKoo Cat#: 592257

Name: Aminohippuric acid

CAS#: 61-78-9 (free acid)

Chemical Formula: C9H10N2O3

Exact Mass: 194.0691

Molecular Weight: 194.19

Elemental Analysis: C, 55.67; H, 5.19; N, 14.43; O, 24.72

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
10g USD 400.00 2 Weeks
25g USD 750.00 2 Weeks
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Synonym
Aminohippuric acid; NSC 13064; NSC-13064; NSC13064; p-Aminohippuric acid; 4-Aminohippuric acid; N-(4-Aminobenzoyl)glycine
IUPAC/Chemical Name
4-Aminohippuric acid
InChi Key
HSMNQINEKMPTIC-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13)
SMILES Code
O=C(C1=CC=C(N)C=C1)NCC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 194.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rodríguez-Romero V, Guízar-Sahagún G, Castañeda-Hernández G, Reyes JL, Cruz-Antonio L. Early Systemic Alterations in Severe Spinal Cord Injury: An Experimental Study on the Impact of Injury Level on Renal Function. Spine (Phila Pa 1976). 2018 Aug 1;43(15):E885-E890. doi: 10.1097/BRS.0000000000002578. PubMed PMID: 29985870. 2: Morimoto K, Tominaga Y, Miyamoto M, Kashiwagura S, Takahashi A, Sano Y, Yano K, Kakinuma C, Ogihara T, Tomita M. Intestinal secretion of indoxyl sulfate as a possible compensatory excretion pathway in chronic kidney disease. Biopharm Drug Dispos. 2018 Jul 5. doi: 10.1002/bdd.2149. [Epub ahead of print] PubMed PMID: 29975986. 3: Skytte Larsson J, Krumbholz V, Enskog A, Bragadottir G, Redfors B, Ricksten SE. Renal Blood Flow, Glomerular Filtration Rate, and Renal Oxygenation in Early Clinical Septic Shock. Crit Care Med. 2018 Jun;46(6):e560-e566. doi: 10.1097/CCM.0000000000003088. PubMed PMID: 29517549. 4: Bjornstad P, Lovshin JA, Lytvyn Y, Boulet G, Lovblom LE, Alhuzaim ON, Farooqi MA, Lai V, Tse J, Cham L, Orszag A, Scarr D, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Perkins BA, Cherney DZI. Adiposity Impacts Intrarenal Hemodynamic Function in Adults With Long-standing Type 1 Diabetes With and Without Diabetic Nephropathy: Results From the Canadian Study of Longevity in Type 1 Diabetes. Diabetes Care. 2018 Apr;41(4):831-839. doi: 10.2337/dc17-2475. Epub 2018 Feb 2. PubMed PMID: 29437821; PubMed Central PMCID: PMC5860840. 5: Zhang Z, Tachikawa M, Uchida Y, Terasaki T. Drug Clearance from Cerebrospinal Fluid Mediated by Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8) at Arachnoid Membrane of Rats. Mol Pharm. 2018 Mar 5;15(3):911-922. doi: 10.1021/acs.molpharmaceut.7b00852. Epub 2018 Feb 21. PubMed PMID: 29436232. 6: Sasaki K, Tachikawa M, Uchida Y, Hirano S, Kadowaki F, Watanabe M, Ohtsuki S, Terasaki T. ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver. Mol Pharm. 2018 Feb 5;15(2):343-355. doi: 10.1021/acs.molpharmaceut.7b00679. Epub 2018 Jan 24. PubMed PMID: 29300488. 7: Qu Y, An F, Luo Y, Lu Y, Liu T, Zhao W, Lin B. A nephron model for study of drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity. Biomaterials. 2018 Feb;155:41-53. doi: 10.1016/j.biomaterials.2017.11.010. Epub 2017 Nov 14. PubMed PMID: 29169037. 8: Chen S, Zhang M, Bo L, Li S, Hu L, Zhao X, Sun C. Metabolomic analysis of the toxic effect of chronic exposure of cadmium on rat urine. Environ Sci Pollut Res Int. 2018 Feb;25(4):3765-3774. doi: 10.1007/s11356-017-0774-8. Epub 2017 Nov 22. PubMed PMID: 29168138. 9: Mathialagan S, Costales C, Tylaska L, Kimoto E, Vildhede A, Johnson J, Johnson N, Sarashina T, Hashizume K, Isringhausen CD, Vermeer LMM, Wolff AR, Rodrigues AD. In vitro studies with two human organic anion transporters: OAT2 and OAT7. Xenobiotica. 2017 Oct 13:1-13. doi: 10.1080/00498254.2017.1384595. [Epub ahead of print] PubMed PMID: 28945155. 10: Matsumoto T, Ishizaki Y, Mochizuki K, Aoyagi M, Mitoma Y, Ishizaki S, Nagashima Y. Urinary Excretion of Tetrodotoxin Modeled in a Porcine Renal Proximal Tubule Epithelial Cell Line, LLC-PK₁. Mar Drugs. 2017 Jul 17;15(7). pii: E225. doi: 10.3390/md15070225. PubMed PMID: 28714912; PubMed Central PMCID: PMC5532667. 11: Fernández-Fígares I, Lachica M, Rojas-Cano ML, González-Casado A. Influence of para-aminohippuric acid analysis on net portal-drained viscera flux of nutrients in pigs. Animal. 2018 Feb;12(2):232-238. doi: 10.1017/S1751731117001598. Epub 2017 Jul 17. PubMed PMID: 28712380. 12: Eggink HM, van Nierop FS, Schooneman MG, Boelen A, Kalsbeek A, Koehorst M, Ten Have GAM, de Brauw LM, Groen AK, Romijn JA, Deutz NEP, Soeters MR. Transhepatic bile acid kinetics in pigs and humans. Clin Nutr. 2018 Aug;37(4):1406-1414. doi: 10.1016/j.clnu.2017.06.015. Epub 2017 Jun 19. PubMed PMID: 28669667. 13: Kimura O, Fujii Y, Haraguchi K, Kato Y, Ohta C, Koga N, Endo T. Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides. Toxicol Lett. 2017 Aug 5;277:18-23. doi: 10.1016/j.toxlet.2017.05.012. Epub 2017 May 25. PubMed PMID: 28552774. 14: Tonneijck L, Muskiet MHA, Smits MM, Hoekstra T, Kramer MHH, Danser AHJ, Diamant M, Joles JA, van Raalte DH. Postprandial renal haemodynamic effect of lixisenatide vs once-daily insulin-glulisine in patients with type 2 diabetes on insulin-glargine: An 8-week, randomised, open-label trial. Diabetes Obes Metab. 2017 Dec;19(12):1669-1680. doi: 10.1111/dom.12985. Epub 2017 Jul 25. PubMed PMID: 28449402. 15: Feng F, Zheng J, Qin P, Han T, Zhao D. A novel quartz crystal microbalance sensor array based on molecular imprinted polymers for simultaneous detection of clenbuterol and its metabolites. Talanta. 2017 May 15;167:94-102. doi: 10.1016/j.talanta.2017.02.001. Epub 2017 Feb 7. PubMed PMID: 28340793. 16: Anastasio P, Viggiano D, Zacchia M, Altobelli C, Capasso G, Gaspare De Santo N. Delay in Renal Hemodynamic Response to a Meat Meal in Severe Obesity. Nephron. 2017;136(2):151-157. doi: 10.1159/000453283. Epub 2017 Mar 23. PubMed PMID: 28329736. 17: Uedono H, Tsuda A, Ishimura E, Nakatani S, Kurajoh M, Mori K, Uchida J, Emoto M, Nakatani T, Inaba M. U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects. Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F992-F997. doi: 10.1152/ajprenal.00645.2016. Epub 2017 Mar 1. PubMed PMID: 28249837. 18: Fischer C, Wessels H, Paschke-Kratzin A, Fischer M. Aptamers: Universal capture units for lateral flow applications. Anal Biochem. 2017 Apr 1;522:53-60. doi: 10.1016/j.ab.2017.01.012. Epub 2017 Jan 19. PubMed PMID: 28111303. 19: Krogh U, Storm AC, Theil PK. Technical note: Measurement of mammary plasma flow in sows by downstream dilution of mammary vein infused -aminohippuric acid. J Anim Sci. 2016 Dec;94(12):5122-5128. doi: 10.2527/jas.2016-0853. PubMed PMID: 28046185. 20: Zheng L, Wei H, He P, Zhao S, Xiang Q, Pang J, Peng J. Effects of Supplementation of Branched-Chain Amino Acids to Reduced-Protein Diet on Skeletal Muscle Protein Synthesis and Degradation in the Fed and Fasted States in a Piglet Model. Nutrients. 2016 Dec 28;9(1). pii: E17. doi: 10.3390/nu9010017. PubMed PMID: 28036018; PubMed Central PMCID: PMC5295061.