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MedKoo Cat#: 461022 | Name: Fluanisone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluanisone is a typical antipsychotic and sedative of the butyrophenone chemical class. It is used in the treatment of schizophrenia and mania. It is also a component (along with fentanyl) of the injectable veterinary formulation fentanyl/fluanisone (Hypnorm) where it is used for rodent analgesia during short surgical procedures.

Chemical Structure

Fluanisone
Fluanisone
CAS#1480-19-9 (free base)

Theoretical Analysis

MedKoo Cat#: 461022

Name: Fluanisone

CAS#: 1480-19-9 (free base)

Chemical Formula: C21H25FN2O2

Exact Mass: 356.1900

Molecular Weight: 356.44

Elemental Analysis: C, 70.76; H, 7.07; F, 5.33; N, 7.86; O, 8.98

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 Weeks
250mg USD 650.00 2 Weeks
500mg USD 950.00 2 Weeks
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Related CAS #
1480-19-9 (free base) 17160-71-3 (HCl)
Synonym
Fluanisone; Fluanison; Haloanison; Haloanisone; MD 2028; MD2028; MD-2028; R2028; R 2028; R-2028; R 2167; R2167; R-2167; NSC 170977; NSC170977; NSC-170977;
IUPAC/Chemical Name
1-(4-fluorophenyl)-4-(4-(2-methoxyphenyl)piperazin-1-yl)butan-1-one
InChi Key
IRYFCWPNDIUQOW-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25FN2O2/c1-26-21-7-3-2-5-19(21)24-15-13-23(14-16-24)12-4-6-20(25)17-8-10-18(22)11-9-17/h2-3,5,7-11H,4,6,12-16H2,1H3
SMILES Code
O=C(C1=CC=C(F)C=C1)CCCN2CCN(C3=CC=CC=C3OC)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 356.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Benato L, Chesnel M, Eatwell K, Meredith A. Arterial blood gas parameters in pet rabbits anaesthetized using a combination of fentanyl-fluanisone-midazolam-isoflurane. J Small Anim Pract. 2013 Jul;54(7):343-6. doi: 10.1111/jsap.12081. Epub 2013 May 10. PubMed PMID: 23659374. 2: Inoue M, Ates N, Vossen JM, Coenen AM. Effects of the neuroleptanalgesic fentanyl-fluanisone (Hypnorm) on spike-wave discharges in epileptic rats. Pharmacol Biochem Behav. 1994 Jun;48(2):547-51. PubMed PMID: 8090830. 3: Flecknell PA, Liles JH, Wootton R. Reversal of fentanyl/fluanisone neuroleptanalgesia in the rabbit using mixed agonist/antagonist opioids. Lab Anim. 1989 Apr;23(2):147-55. PubMed PMID: 2709794. 4: Martinez MA, Murison PJ, Love E. Induction of anaesthesia with either midazolam or propofol in rabbits premedicated with fentanyl/fluanisone. Vet Rec. 2009 Jun 27;164(26):803-6. PubMed PMID: 19561349. 5: Flecknell PA, Mitchell M. Midazolam and fentanyl-fluanisone: assessment of anaesthetic effects in laboratory rodents and rabbits. Lab Anim. 1984 Apr;18(2):143-6. PubMed PMID: 6748593. 6: Hexeberg E, Hexeberg S, Hessevik I, Fosse RT. Midazolam in combination with fentanyl/fluanisone and nitrous oxide as anaesthesia in rabbits--cardiovascular parameters. Lab Anim. 1995 Oct;29(4):400-6. PubMed PMID: 8558822. 7: Jong WM, Zuurbier CJ, De Winter RJ, Van Den Heuvel DA, Reitsma PH, Ten Cate H, Ince C. Fentanyl-fluanisone-midazolam combination results in more stable hemodynamics than does urethane alpha-chloralose and 2,2,2-tribromoethanol in mice. Contemp Top Lab Anim Sci. 2002 May;41(3):28-32. PubMed PMID: 12051657. 8: Wingerter J. [Use of Fluanisone in the EEG laboratory in current practice]. Encephale. 1967 Mar-Apr;56(2):151-65. French. PubMed PMID: 4383430. 9: Skolleborg KC, Grönbech JE, Grong K, Abyholm FE, Lekven J. Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anaesthesia in the rat. Lab Anim. 1990 Jul;24(3):221-7. PubMed PMID: 2144326. 10: Sharp PS, Shaw K, Boorman L, Harris S, Kennerley AJ, Azzouz M, Berwick J. Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime. Sci Rep. 2015 Jul 28;5:12621. doi: 10.1038/srep12621. Erratum in: Sci Rep. 2015;5:14890. PubMed PMID: 26218081; PubMed Central PMCID: PMC4517464. 11: Clowry GJ, Flecknell PA. The successful use of fentanyl/fluanisone ('Hypnorm') as an anaesthetic for intracranial surgery in neonatal rats. Lab Anim. 2000 Jul;34(3):260-4. PubMed PMID: 11037119. 12: Wolfensohn SE. Use of medetomidine-fentanyl-fluanisone combinations in the badger. Vet Rec. 1992 Jan 11;130(2):34-6. PubMed PMID: 1347435. 13: Carter AM. Acid-base status of pregnant guinea pigs during neuroleptanalgesia with diazepam and fentanyl-fluanisone. Lab Anim. 1983 Apr;17(2):114-7. PubMed PMID: 6865317. 14: Antunes LM, Roughan JV, Flecknell PA. Evaluation of auditory evoked potentials to predict depth of anaesthesia during fentanyl/fluanisone-midazolam anaesthesia in rats. Vet Anaesth Analg. 2001 Oct;28(4):196-203. doi: 10.1046/j.1467-2987.2001.00059.x. Epub 2016 Nov 15. PubMed PMID: 28404244. 15: Quaglio MP, Bellini AM. A gas chromatographic method for the determination of fluanisone, moperone, aceperone and pipamperone in human plasma. Farmaco Prat. 1981 Apr;36(4):204-14. PubMed PMID: 6112157. 16: West CD, Green CJ. The sedative effects of climazolam and climazolam with fentanyl-fluanisone in rats (Rattus norvegicus). Lab Anim. 1987 Apr;21(2):143-8. PubMed PMID: 3496489. 17: Labat J, Fournier A, Gardey P, Guelain J. [Pharmacodynamic activation of the electroencephalogram: place of fluanisone]. Rev Corps Sante Armees Terre Mer Air. 1969 Aug;10(4):429-43. French. PubMed PMID: 4245981. 18: Naess V, Fosse RT, Hofstad T. A possible effect on the Shwartzman reaction in the rabbit caused by fentanyl-fluanisone tranquillization. Lab Anim. 1986 Oct;20(4):304-6. PubMed PMID: 3773435. 19: Robert G. [Comparative trials on sultopride and fluanisone]. Encephale. 1978;4(2):145-161. French. PubMed PMID: 28939. 20: Hayton SM, Kriss A, Muller DP. Comparison of the effects of four anaesthetic agents on somatosensory evoked potentials in the rat. Lab Anim. 1999 Jul;33(3):243-51. PubMed PMID: 10780843.