IRC-083864 | CAS#1142057-18-8 | CDC25 inhibitor

MedKoo Cat#: 584477 | Name: IRC-083864

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IRC-083864 is a novel bis quinone inhibitor of CDC25 phosphatases active against human cancer cells.

Chemical Structure

IRC-083864

CAS#1142057-18-8

Theoretical Analysis

MedKoo Cat#: 584477

Name: IRC-083864

CAS#: 1142057-18-8

Chemical Formula: C28H27F2N5O5S

Exact Mass: 583.1701

Molecular Weight: 583.61

Elemental Analysis: C, 57.63; H, 4.66; F, 6.51; N, 12.00; O, 13.71; S, 5.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IRC-083864; IRC 083864; IRC083864

IUPAC/Chemical Name

4,7-Benzoxazoledione, 2-(2,5-difluorophenyl)-6-((3-((3-((4,7-dihydro-2-methyl-4,7-dioxo-5-benzothiazolyl)amino)propyl)methylamino)propyl)amino)-

InChi Key

DXPDTYBBNUNWEY-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H27F2N5O5S/c1-14-33-23-24(37)18(12-19(36)28(23)41-14)31-7-3-9-35(2)10-4-8-32-20-13-40-27-22(34-20)25(38)21(26(27)39)16-11-15(29)5-6-17(16)30/h5-6,11-12,21,31H,3-4,7-10,13H2,1-2H3,(H,32,34)

SMILES Code

CN(CCCNC1=NC(C(C2C3=CC(F)=CC=C3F)=O)=C(OC1)C2=O)CCCNC(C4=O)=CC(C5=C4N=C(C)S5)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 583.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brezak MC, Valette A, Quaranta M, Contour-Galcera MO, Jullien D, Lavergne O, Frongia C, Bigg D, Kasprzyk PG, Prevost GP, Ducommun B. IRC-083864, a novel bis quinone inhibitor of CDC25 phosphatases active against human cancer cells. Int J Cancer. 2009 Mar 15;124(6):1449-56. doi: 10.1002/ijc.24080. PubMed PMID: 19065668. 2: Frongia C, Lorenzo C, Gianni F, Prevost GP, Ducommun B, Lobjois V. 3D imaging of the response to CDC25 inhibition in multicellular spheroids. Cancer Biol Ther. 2009 Dec;8(23):2230-36. Epub 2009 Dec 3. PubMed PMID: 19823027. 3: Bertoli S, Boutzen H, David L, Larrue C, Vergez F, Fernandez-Vidal A, Yuan L, Hospital MA, Tamburini J, Demur C, Delabesse E, Saland E, Sarry JE, Galcera MO, Mansat-De Mas V, Didier C, Dozier C, Récher C, Manenti S. CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia. Oncotarget. 2015 Nov 10;6(35):38061-78. doi: 10.18632/oncotarget.5706. PubMed PMID: 26515730; PubMed Central PMCID: PMC4741984. 4: Sarkis M, Miteva MA, Dasso Lang MC, Jaouen M, Sari MA, Galcéra MO, Ethève-Quelquejeu M, Garbay C, Bertho G, Braud E. Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25. Proteins. 2017 Apr;85(4):593-601. doi: 10.1002/prot.25236. Epub 2017 Jan 18. PubMed PMID: 28056492. 5: Warden R, Saunders J, Tsourkas A. Two-photon imaging of multicellular tumor spheroids: a novel method for evaluating the efficacy of CDC25 phosphatase inhibitors. Cancer Biol Ther. 2009 Dec;8(23):2237-8. Epub 2009 Dec 7. PubMed PMID: 19855193.