Ro 22-3581 | CAS#10041-06-2 | Thromboxane synthase inhibitor

MedKoo Cat#: 464432 | Name: Ro 22-3581

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 22-3581 is a selective inhibitor of thromboxane synthase. It has been shown to be useful for investigating the relationship between hyperinsulinemia and obesity.

Chemical Structure

Ro 22-3581

CAS#10041-06-2

Theoretical Analysis

MedKoo Cat#: 464432

Name: Ro 22-3581

CAS#: 10041-06-2

Chemical Formula: C11H10N2O

Exact Mass: 186.0793

Molecular Weight: 186.21

Elemental Analysis: C, 70.95; H, 5.41; N, 15.04; O, 8.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Ro 22-3581; Ro 22 3581; Ro 223581;

IUPAC/Chemical Name

1-(4-(1H-imidazol-1-yl)phenyl)ethan-1-one

InChi Key

GAIQQJIMVVUTQN-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H10N2O/c1-9(14)10-2-4-11(5-3-10)13-7-6-12-8-13/h2-8H,1H3

SMILES Code

CC(c1ccc(n2cncc2)cc1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 186.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Craven PA, DeRubertis FR. Suppression of urinary albumin excretion in diabetic rats by 4'(imidazol-1-yl) acetophenone, a selective inhibitor of thromboxane synthesis. J Lab Clin Med. 1990 Oct;116(4):469-78. PMID: 2212856. 2: Triscari J, Sullivan AC. A pharmacotherapeutic approach to the regulation of hyperinsulinemia and obesity. Int J Obes. 1987;11 Suppl 3:43-51. PMID: 3326847. 3: Watson AJ, Stout RL, Adkinson NF Jr, Solez K, Whelton A. Selective inhibition of thromboxane synthesis in glycerol-induced acute renal failure. Am J Kidney Dis. 1986 Jul;8(1):26-30. doi: 10.1016/s0272-6386(86)80150-0. PMID: 3755284. 4: Uderman HD, Workman RJ, Jackson EK. Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone. Prostaglandins. 1982 Aug;24(2):237-44. doi: 10.1016/0090-6980(82)90149-6. PMID: 6897296. 5: Watkins WD, Hüttemeier PC, Kong D, Peterson MB. Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: effect of an imidazole derivative. Prostaglandins. 1982 Mar;23(3):273-85. doi: 10.1016/0090-6980(82)90073-9. PMID: 7048422. 6: Udey MC, Parker CW. Effect of inhibitors of arachidonic acid metabolism on alpha-aminoisobutyric acid transport in human lymphocytes. Biochem Pharmacol. 1982 Feb 1;31(3):337-45. doi: 10.1016/0006-2952(82)90180-0. PMID: 6803809.