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MedKoo Cat#: 597910 | Name: JMV-1645

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JMV-1645 is a potent and selective B(1) bradykinin receptor antagonist.

Chemical Structure

JMV-1645
JMV-1645
CAS#284037-77-0

Theoretical Analysis

MedKoo Cat#: 597910

Name: JMV-1645

CAS#: 284037-77-0

Chemical Formula: C49H69N13O12S

Exact Mass: 1063.4909

Molecular Weight: 1064.23

Elemental Analysis: C, 55.30; H, 6.54; N, 17.11; O, 18.04; S, 3.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JMV-1645; JMV 1645; JMV1645;
IUPAC/Chemical Name
2-((3S)-3-(2-(2-((2S,4R)-1-(L-lysyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carboxamido)acetamido)-N-((S)-1-amino-3-hydroxy-1-oxopropan-2-yl)-2-(2,3-dihydro-1H-inden-2-yl)acetamido)-4-oxo-3,4-dihydrobenzo[b][1,4]thiazepin-5(2H)-yl)acetic acid
InChi Key
FXTFICQJMBHGPE-XMLMJMRQSA-N
InChi Code
InChI=1S/C49H69N13O12S/c50-16-6-5-11-31(51)43(69)57-32(12-7-17-55-49(53)54)45(71)59-18-8-14-34(59)46(72)60-23-30(64)21-35(60)44(70)56-22-39(65)58-41(29-19-27-9-1-2-10-28(27)20-29)48(74)62(36(25-63)42(52)68)37-26-75-38-15-4-3-13-33(38)61(47(37)73)24-40(66)67/h1-4,9-10,13,15,29-32,34-37,41,63-64H,5-8,11-12,14,16-26,50-51H2,(H2,52,68)(H,56,70)(H,57,69)(H,58,65)(H,66,67)(H4,53,54,55)/t30-,31+,32+,34+,35+,36+,37-,41?/m1/s1
SMILES Code
OC[C@@H](C(N)=O)N(C(C(C1CC2=C(C=CC=C2)C1)NC(CNC([C@H]3N(C([C@H]4N(C([C@H](CCCNC(N)=N)NC([C@H](CCCCN)N)=O)=O)CCC4)=O)C[C@H](O)C3)=O)=O)=O)[C@@H]5CSC6=CC=CC=C6N(CC(O)=O)C5=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,064.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bedos P, Amblard M, Subra G, Dodey P, Luccarini JM, Paquet JL, Pruneau D, Aumelas A, Martinez J. A rational approach to the design and synthesis of a new bradykinin B(1) receptor antagonist. J Med Chem. 2000 Jun 15;43(12):2387-94. PubMed PMID: 10882365.

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