MedKoo Cat#: 597907 | Name: Antibiotic tan-592B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Antibiotic tan-592B is an antibiotic.

Chemical Structure

Antibiotic tan-592B
Antibiotic tan-592B
CAS#99685-75-3

Theoretical Analysis

MedKoo Cat#: 597907

Name: Antibiotic tan-592B

CAS#: 99685-75-3

Chemical Formula: C29H47ClN10O14S

Exact Mass: 826.2682

Molecular Weight: 827.26

Elemental Analysis: C, 42.11; H, 5.73; Cl, 4.29; N, 16.93; O, 27.08; S, 3.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Antibiotic tan-592B; Cephabacin F5 hydrochloride; TAN-592B; TAN 592B; TAN592B;
IUPAC/Chemical Name
(6R,7S)-7-(5-amino-5-carboxypentanamido)-3-((((4S)-4-(((2R,3R,5S)-1,5-diamino-3,6-dihydroxy-1,4-dioxohexan-2-yl)amino)-7-guanidino-3-hydroxyheptanoyl)oxy)methyl)-7-formamido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
InChi Key
FQWMHKOCOXEZJI-FROSJRLKSA-N
InChi Code
InChI=1S/C29H46N10O14S.ClH/c30-13(24(48)49)3-1-5-17(43)38-29(36-11-41)26(52)39-20(25(50)51)12(10-54-27(29)39)9-53-18(44)7-16(42)15(4-2-6-35-28(33)34)37-19(23(32)47)22(46)21(45)14(31)8-40;/h11,13-16,19,22,27,37,40,42,46H,1-10,30-31H2,(H2,32,47)(H,36,41)(H,38,43)(H,48,49)(H,50,51)(H4,33,34,35);1H/t13?,14-,15-,16?,19+,22+,27+,29-;/m0./s1
SMILES Code
O=C1[C@](NC=O)(NC(CCCC(N)C(O)=O)=O)[C@@H]2N1C(C(O)=O)=C(COC(CC(O)[C@@H](N[C@@H](C(N)=O)[C@@H](O)C([C@@H](N)CO)=O)CCCNC(N)=N)=O)CS2.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 827.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hicks LA, Bartoces MG, Roberts RM, Suda KJ, Hunkler RJ, Taylor TH Jr, Schrag SJ. US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011. Clin Infect Dis. 2015 May 1;60(9):1308-16. doi: 10.1093/cid/civ076. Epub 2015 Mar 5. PubMed PMID: 25747410. 2: Plantinga NL, Wittekamp BH, van Duijn PJ, Bonten MJ. Fighting antibiotic resistance in the intensive care unit using antibiotics. Future Microbiol. 2015;10(3):391-406. doi: 10.2217/fmb.14.146. Review. PubMed PMID: 25812462. 3: Sandegren L. Selection of antibiotic resistance at very low antibiotic concentrations. Ups J Med Sci. 2014 May;119(2):103-7. doi: 10.3109/03009734.2014.904457. Epub 2014 Apr 3. Review. PubMed PMID: 24694026; PubMed Central PMCID: PMC4034545. 4: Na SY, Oh SH, Kim TH, Yoon JA, Lee IS, Lee JH. Sustained release of antibiotic complexed by multivalent ion: in vitro and in vivo study for the treatment of peritonitis. Int J Pharm. 2014 Dec 10;476(1-2):213-22. doi: 10.1016/j.ijpharm.2014.09.054. Epub 2014 Oct 1. PubMed PMID: 25280885. 5: Saari A, Virta LJ, Sankilampi U, Dunkel L, Saxen H. Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life. Pediatrics. 2015 Apr;135(4):617-26. doi: 10.1542/peds.2014-3407. PubMed PMID: 25825533. 6: Meisner M. Update on procalcitonin measurements. Ann Lab Med. 2014 Jul;34(4):263-73. doi: 10.3343/alm.2014.34.4.263. Epub 2014 Jun 19. Review. PubMed PMID: 24982830; PubMed Central PMCID: PMC4071182. 7: Huibers L, Moth G, Christensen MB, Vedsted P. Antibiotic prescribing patterns in out-of-hours primary care: a population-based descriptive study. Scand J Prim Health Care. 2014 Dec;32(4):200-7. doi: 10.3109/02813432.2014.972067. Epub 2014 Oct 28. PubMed PMID: 25350313; PubMed Central PMCID: PMC4278398. 8: Schäberle TF, Hack IM. Overcoming the current deadlock in antibiotic research. Trends Microbiol. 2014 Apr;22(4):165-7. doi: 10.1016/j.tim.2013.12.007. PubMed PMID: 24698433. 9: Mohammadinejad P, Ataeinia B, Kaynejad K, Zeinoddini A, Sadeghi B, Hosseini M, Rezaei N, Aghamohammadi A. Antibiotic resistance in patients with primary immunodeficiency disorders versus immunocompetent patients. Expert Rev Clin Immunol. 2015;11(10):1163-72. doi: 10.1586/1744666X.2015.1075396. Epub 2015 Aug 2. PubMed PMID: 26289374. 10: Deconinck L, Maillard H, Lemaitre M, Barbottin E, Bakhache E, Galperine T, Puisieux F, Hatron PY, Lambert M. [Adequacy of antibiotic therapy for urinary tract infection in a Medical Department from the university hospital of Lille: A retrospective cohort study]. Rev Med Interne. 2015 Nov;36(11):728-37. doi: 10.1016/j.revmed.2015.07.012. Epub 2015 Sep 4. French. PubMed PMID: 26343874. 11: Spicknall IH, Foxman B, Marrs CF, Eisenberg JN. A modeling framework for the evolution and spread of antibiotic resistance: literature review and model categorization. Am J Epidemiol. 2013 Aug 15;178(4):508-20. doi: 10.1093/aje/kwt017. Epub 2013 May 9. Review. PubMed PMID: 23660797; PubMed Central PMCID: PMC3736756. 12: Ouwehand AC, Forssten S, Hibberd AA, Lyra A, Stahl B. Probiotic approach to prevent antibiotic resistance. Ann Med. 2016;48(4):246-55. doi: 10.3109/07853890.2016.1161232. Epub 2016 Mar 26. Review. PubMed PMID: 27092975. 13: Kotwani A, Wattal C, Joshi PC, Holloway K. Knowledge and perceptions on antibiotic use and resistance among high school students and teachers in New Delhi, India: A qualitative study. Indian J Pharmacol. 2016 Jul-Aug;48(4):365-371. PubMed PMID: 27756945; PubMed Central PMCID: PMC4980922. 14: Ab Rahman N, Teng CL, Sivasampu S. Antibiotic prescribing in public and private practice: a cross-sectional study in primary care clinics in Malaysia. BMC Infect Dis. 2016 May 17;16:208. doi: 10.1186/s12879-016-1530-2. PubMed PMID: 27188538; PubMed Central PMCID: PMC4869350. 15: Raz R. Fosfomycin: an old--new antibiotic. Clin Microbiol Infect. 2012 Jan;18(1):4-7. doi: 10.1111/j.1469-0691.2011.03636.x. Epub 2011 Sep 13. Review. PubMed PMID: 21914036. 16: El-Hennawi DM, Ahmed MR, Farid AM, Al Murtadah AM. Comparative study of the efficacy of topical steroid and antibiotic combination therapy versus oral antibiotic alone when treating acute rhinosinusitis. J Laryngol Otol. 2015 May;129(5):462-7. doi: 10.1017/S0022215115000456. Epub 2015 Apr 14. PubMed PMID: 25869467. 17: Piovani D, Clavenna A, Cartabia M, Bortolotti A, Fortino I, Merlino L, Bonati M. Comparing recurrent antibiotic prescriptions in children treated with a brand name or a generic formulation. Pharmacoepidemiol Drug Saf. 2015 Feb;24(2):121-8. doi: 10.1002/pds.3654. Epub 2014 Jun 9. PubMed PMID: 24910387. 18: Beneš J. [Dawn of the antibiotic era and some consequences for the present]. Klin Mikrobiol Infekc Lek. 2012 Oct;18(5):142-9. Review. Czech. PubMed PMID: 23208868. 19: Pollack LA, van Santen KL, Weiner LM, Dudeck MA, Edwards JR, Srinivasan A. Antibiotic Stewardship Programs in U.S. Acute Care Hospitals: Findings From the 2014 National Healthcare Safety Network Annual Hospital Survey. Clin Infect Dis. 2016 Aug 15;63(4):443-9. doi: 10.1093/cid/ciw323. Epub 2016 May 19. PubMed PMID: 27199462. 20: Nair M, Krishnan A. Antibiotic releasing biodegradable scaffolds for osteomyelitis. Curr Drug Deliv. 2014;11(6):687-700. Review. PubMed PMID: 24730438.