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MedKoo Cat#: 597906 | Name: Scopolamine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Scopolamine is an alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.

Chemical Structure

Scopolamine
Scopolamine
CAS#51-34-3 (free)

Theoretical Analysis

MedKoo Cat#: 597906

Name: Scopolamine

CAS#: 51-34-3 (free)

Chemical Formula: C17H21NO4

Exact Mass: 303.1471

Molecular Weight: 303.35

Elemental Analysis: C, 67.31; H, 6.98; N, 4.62; O, 21.10

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 2 Weeks
250mg USD 550.00 2 Weeks
1g USD 1,450.00 2 Weeks
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Related CAS #
114-49-8 (HBr) 55-16-3 (HCl) 51-34-3 (free) 6533-68-2 (HBr trihydrate)
Synonym
Scopolamine; l-Scopolamine; Transderm SCOP; SEE; Hyoscine; (−)-Scopolamine; Isoptpo Hyoscine
IUPAC/Chemical Name
(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate
InChi Key
STECJAGHUSJQJN-FWXGHANASA-N
InChi Code
InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1
SMILES Code
O=C(O[C@H]1C[C@@]2([H])[C@]3([H])O[C@]3([H])[C@@](N2C)([H])C1)[C@H](CO)C4=CC=CC=C4
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO and ethanol
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Scopolamine competitively inhibits muscarinic receptors for acetylcholine and acts as a nonselective muscarinic antagonist, producing both peripheral antimuscarinic properties and central sedative, antiemetic, and amnestic effects.
In vitro activity:
Scopolamine has potential as a treatment against Pythophthora infestans, a pathogen of potato blight. Scopolamine inhibited the mycelial growth of P. infestans with an IC50 value of 4.25 g L-1. Transcriptome analysis suggested that scopolamine led to a downregulation of most P. infestans genes functioning in cell growth, cell metabolism, and pathogenicity. Reference: J Sci Food Agric. 2023 Oct;103(13):6416-6428. https://pubmed.ncbi.nlm.nih.gov/37209269/
In vivo activity:
In a male Wistar rat model of Alzheimer’s disease, scopolamine administration may exacerbate or worsen certain Alzheimer’s disease-related biomarkers. After scopolamine administration, there was increased Aβ deposition in the hippocampus and an increase in GSK3βP9. There was also a state of oxidative stress in scopolamine-treated groups. Reference: Mol Neurobiol. 2020 Sep;57(9):3979-3988. https://pubmed.ncbi.nlm.nih.gov/32638218/
Solvent mg/mL mM
Solubility
DMSO 5.0 26.09
Ethanol 1.0 5.22
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 303.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Zhu Z, Xiong Z, Zou W, Shi Z, Li S, Zhang X, Liu S, Liu Y, Luo X, Ren J, Zhu Z, Dong P. Anti-oomycete ability of scopolamine against Phytophthora infestans, a terrible pathogen of potato late blight. J Sci Food Agric. 2023 Oct;103(13):6416-6428. doi: 10.1002/jsfa.12717. Epub 2023 May 31. PMID: 37209269. 2. Wang X, Zhu X, Ji X, Yang J, Zhou J. Group-Based Symptom Trajectory of Intramuscular Administration of Scopolamine Augmentation in Moderate to Severe Major Depressive Disorder: A Post-Hoc Analysis. Neuropsychiatr Dis Treat. 2023 May 1;19:1043-1053. doi: 10.2147/NDT.S408794. PMID: 37153351; PMCID: PMC10162387. 3. Hernández-Rodríguez M, Arciniega-Martínez IM, García-Marín ID, Correa-Basurto J, Rosales-Hernández MC. Chronic Administration of Scopolamine Increased GSK3βP9, Beta Secretase, Amyloid Beta, and Oxidative Stress in the Hippocampus of Wistar Rats. Mol Neurobiol. 2020 Sep;57(9):3979-3988. doi: 10.1007/s12035-020-02009-x. Epub 2020 Jul 7. PMID: 32638218.=
In vitro protocol:
1. Zhu Z, Xiong Z, Zou W, Shi Z, Li S, Zhang X, Liu S, Liu Y, Luo X, Ren J, Zhu Z, Dong P. Anti-oomycete ability of scopolamine against Phytophthora infestans, a terrible pathogen of potato late blight. J Sci Food Agric. 2023 Oct;103(13):6416-6428. doi: 10.1002/jsfa.12717. Epub 2023 May 31. PMID: 37209269.
In vivo protocol:
1. Wang X, Zhu X, Ji X, Yang J, Zhou J. Group-Based Symptom Trajectory of Intramuscular Administration of Scopolamine Augmentation in Moderate to Severe Major Depressive Disorder: A Post-Hoc Analysis. Neuropsychiatr Dis Treat. 2023 May 1;19:1043-1053. doi: 10.2147/NDT.S408794. PMID: 37153351; PMCID: PMC10162387. 2. Hernández-Rodríguez M, Arciniega-Martínez IM, García-Marín ID, Correa-Basurto J, Rosales-Hernández MC. Chronic Administration of Scopolamine Increased GSK3βP9, Beta Secretase, Amyloid Beta, and Oxidative Stress in the Hippocampus of Wistar Rats. Mol Neurobiol. 2020 Sep;57(9):3979-3988. doi: 10.1007/s12035-020-02009-x. Epub 2020 Jul 7. PMID: 32638218.=
1: Tan N, Wang Y, Ren L, Tie F, Hu N, Wang H, Dong Q. Network Pharmacology and Molecular Dynamics Simulations Reveal the Mechanism of Total Alkaloid Components in Anisodus tanguticus (Maxim.) Pascher in Treating Inflammation and Pain. Chem Biodivers. 2024 Sep 23:e202401199. doi: 10.1002/cbdv.202401199. Epub ahead of print. PMID: 39313870. 2: Li MJ, Xu JY, Zhang HY, Guo M, Lan MN, Kong J, Liu SW, Zheng HJ. A medicine and food homology formula prevents cognitive deficits by inhibiting neuroinflammation and oxidative stress via activating AEA-Trpv1-Nrf2 pathway. Inflammopharmacology. 2024 Sep 21. doi: 10.1007/s10787-024-01570-4. Epub ahead of print. PMID: 39305407. 3: Myint SLL, Rodsiri R, Benya-Aphikul H, Rojanaratha T, Ritthidej G, Islamie R. Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in Mice. Adv Pharmacol Pharm Sci. 2024 Sep 9;2024:9941034. doi: 10.1155/2024/9941034. PMID: 39286638; PMCID: PMC11405110. 4: Marcelino AC, da Cunha Pereira P, Charles CM, Espejo-Arce X, Bahamondes L. Pain relief during intrauterine device placement in nulligravid women with both oral ketorolac and an analgesic: a double-blinded randomised trial. Eur J Contracept Reprod Health Care. 2024 Sep 16:1-6. doi: 10.1080/13625187.2024.2398440. Epub ahead of print. PMID: 39279687. 5: Kim Y, Cho M, Lee JS, Oh J, Lim J. Protocatechuic Acid from Euonymus alatus Mitigates Scopolamine-Induced Memory Impairment in Mice. Foods. 2024 Aug 23;13(17):2664. doi: 10.3390/foods13172664. PMID: 39272430; PMCID: PMC11394611. 6: Kumar S, Rastogi SK, Roy S, Sharma K, Kumar S, Maity D, Chand D, Vishwakarma S, Gayen JR, Srivastava KR, Kumar R, Yadav PN. Discovery and structure - activity relationships of 2,4,5-trimethoxyphenyl pyrimidine derivatives as selective D5 receptor partial agonists. Bioorg Chem. 2024 Sep 7;153:107809. doi: 10.1016/j.bioorg.2024.107809. Epub ahead of print. 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PMID: 39238384. 9: Cusin C, Dillon DG, Belleau E, Normandin MD, Petibon Y, El-Fakri G, Dhaynaut M, Hooker J, Kaptchuk T, McKee M, Hayden E, Meyer A, Jahan A, Origlio J, Ang YS, Brunner D, Kang M, Long Y, Fava M, Pizzagalli DA. Novel multi-modal methodology to investigate placebo response in major depressive disorder. J Affect Disord. 2024 Sep 2;368:1-7. doi: 10.1016/j.jad.2024.08.226. Epub ahead of print. PMID: 39233242. 10: Zhang YX, Niu XY, Xiao ZY, Wang MT, Zheng H. Scopolamine for patients with motion sickness: a systematic review and meta-analysis with trial sequential analysis. Acta Otolaryngol. 2024 Sep 3:1-10. doi: 10.1080/00016489.2024.2397556. Epub ahead of print. PMID: 39225593. 11: Lin J, Cai Z, Lin Y, Wu H, Gu Y. Efficacy of Low-Dose Scopolamine and Palonosetron in Reducing Immediate Post-Gastrointestinal Endoscopy Nausea and Vomiting: A Prospective, Randomized, Controlled Study. J Clin Pharmacol. 2024 Sep 3. doi: 10.1002/jcph.6127. Epub ahead of print. PMID: 39223994. 12: Malek R, Sałat K, Totoson P, Karcz T, Refouvelet B, Skrzypczak-Wiercioch A, Maj M, Simakov A, Martin H, Siwek A, Szałaj N, Godyń J, Panek D, Więckowska A, Jozwiak K, Demougeot C, Kieć-Kononowicz K, Chabchoub F, Iriepa I, Marco- Contelles J, Ismaili L. Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors. ACS Chem Neurosci. 2024 Sep 18;15(18):3363-3383. doi: 10.1021/acschemneuro.4c00341. Epub 2024 Aug 29. PMID: 39208251. 13: Gu X, Song Y, Liu X, Cheng Z, Min J, Zhang Y. METTL14-Mediated m6A Modification of TUG1 Represses Ferroptosis in Alzheimer's Disease via Inhibiting GDF15 Ubiquitination. Front Biosci (Landmark Ed). 2024 Aug 21;29(8):298. doi: 10.31083/j.fbl2908298. PMID: 39206905. 14: Vishnumurthy RH, Priya MGR, Tiwari P, Solomon VR. In-silico Studies and Antioxidant and Neuroprotective Assessment of Microencapsulated Celecoxib against Scopolamine-induced Alzheimer's Disease. Curr Pharm Des. 2024 Aug 28. doi: 10.2174/0113816128298289240723103828. Epub ahead of print. PMID: 39206485. 15: Shagufta, Ali G, Khan A, Rasheed A, Deeba F, Ullah R, Shahid M, Ali H, Khan R, Shamezai N, Sharif N. Evaluation of the Ameliorative Potential of 3,5-bis(2-hydroxyethyl)-1,3,5-thiadiazinane-2-thione against Scopolamine- Induced Alzheimer's Disease. Int J Mol Sci. 2024 Aug 22;25(16):9104. doi: 10.3390/ijms25169104. PMID: 39201791; PMCID: PMC11354520. 16: Lim CJM, Bray J, Janhunen SK, Platt B, Riedel G. Mouse Exploratory Behaviour in the Open Field with and without NAT-1 EEG Device: Effects of MK801 and Scopolamine. Biomolecules. 2024 Aug 15;14(8):1008. doi: 10.3390/biom14081008. PMID: 39199395; PMCID: PMC11352671. 17: Sadiq MH, Al-Zubaidy AA. Neuroprotective Effect of Famotidine in Mouse Models of Alzheimer's Disease. Clin Lab. 2024 Aug 1;70(8). doi: 10.7754/Clin.Lab.2024.240147. PMID: 39193965. 18: Kim HY, Lee JD, Kim H, Kim Y, Park JJ, Oh SB, Goo H, Cho KJ, Kim KB. 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