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MedKoo Cat#: 563308 | Name: ML367
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML367 is an inhibitor of ATAD5 stabilization.

Chemical Structure

ML367
ML367
CAS#381168-77-0

Theoretical Analysis

MedKoo Cat#: 563308

Name: ML367

CAS#: 381168-77-0

Chemical Formula: C23H15ClF2N2O2

Exact Mass: 424.0790

Molecular Weight: 424.83

Elemental Analysis: C, 65.03; H, 3.56; Cl, 8.34; F, 8.94; N, 6.59; O, 7.53

Price and Availability

Size Price Availability Quantity
50mg USD 250.00 2 weeks
100mg USD 450.00 2 weeks
200mg USD 850.00 2 weeks
500mg USD 1,850.00 2 weeks
1g USD 2,950.00 2 weeks
2g USD 4,850.00 2 weeks
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Related CAS #
No Data
Synonym
ML367; ML-367; ML 367;
IUPAC/Chemical Name
(S)-9b-(4-Chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one
InChi Key
GXBAKXRLQAPKEE-QHCPKHFHSA-N
InChi Code
InChI=1S/C23H15ClF2N2O2/c24-16-8-6-15(7-9-16)23-18-4-2-1-3-17(18)22(30)28(23)12-11-27(23)21(29)14-5-10-19(25)20(26)13-14/h1-10,13H,11-12H2/t23-/m0/s1
SMILES Code
O=C1N2[C@@](N(C(C3=CC=C(F)C(F)=C3)=O)CC2)(C4=CC=C(Cl)C=C4)C5=C1C=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity.
In vitro activity:
This study details the discovery of ML367, a probe molecule that has low micromolar inhibitory activity in the ATAD5 destabilizer screen run with 10 μM 5-fluorouridine (5-FUrd) as the DNA damaging agent. Interestingly, ML367 was found to block general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. Reference: Probe Reports from the NIH Molecular Libraries Program [Internet]. 2013 Apr 15 [updated 2013 Nov 14]. https://pubmed.ncbi.nlm.nih.gov/24479200/
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMSO 96.0 225.97
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 424.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Rohde JM, Rai G, Choi YJ, Sakamuru S, Fox JT, Huang R, Xia M, Myung K, Boxer MB, Maloney DJ. Discovery of ML367, inhibitor of ATAD5 stabilization. 2013 Apr 15 [updated 2013 Nov 14]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 24479200.
In vitro protocol:
Rohde JM, Rai G, Choi YJ, Sakamuru S, Fox JT, Huang R, Xia M, Myung K, Boxer MB, Maloney DJ. Discovery of ML367, inhibitor of ATAD5 stabilization. 2013 Apr 15 [updated 2013 Nov 14]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 24479200.
In vivo protocol:
TBD
1: Rohde JM, Rai G, Choi YJ, Sakamuru S, Fox JT, Huang R, Xia M, Myung K, Boxer MB, Maloney DJ. Discovery of ML367, inhibitor of ATAD5 stabilization. 2013 Apr 15 [updated 2013 Nov 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK179831/ PubMed PMID: 24479200.

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