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MedKoo Cat#: 597871 | Name: Arginylproline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arginylproline is a dipeptide composed of arginine and proline. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.

Chemical Structure

Arginylproline
CAS#2418-69-1

Theoretical Analysis

MedKoo Cat#: 597871

Name: Arginylproline

CAS#: 2418-69-1

Chemical Formula: C11H21N5O3

Exact Mass: 271.1644

Molecular Weight: 271.32

Elemental Analysis: C, 48.70; H, 7.80; N, 25.81; O, 17.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Arginylproline; Arg-pro; H-Arg-Pro-OH;
IUPAC/Chemical Name
L-arginyl-L-proline
InChi Key
LQJAALCCPOTJGB-YUMQZZPRSA-N
InChi Code
InChI=1S/C11H21N5O3/c12-7(3-1-5-15-11(13)14)9(17)16-6-2-4-8(16)10(18)19/h7-8H,1-6,12H2,(H,18,19)(H4,13,14,15)/t7-,8-/m0/s1
SMILES Code
O=C(O)[C@H]1N(C([C@H](CCCNC(N)=N)N)=O)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 271.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ferrasi AC, Puttini R, Galvani AF, Hamamoto Filho PT, Delafiori J, Argente VD, de Oliveira AN, Dias-Audibert FL, Catharino RR, Silva OC, Zanini MA, Kurokawa GA, Lima EO. Metabolomics Approach Reveals Important Glioblastoma Plasma Biomarkers for Tumor Biology. Int J Mol Sci. 2023 May 16;24(10):8813. doi: 10.3390/ijms24108813. PMID: 37240159; PMCID: PMC10218163. 2: Mitchell WM. Hydrolysis at arginylproline in polypeptides by clostridiopeptidase B. Science. 1968 Oct 18;162(3851):374-5. doi: 10.1126/science.162.3851.374. PMID: 5677534. 3: Li X, Niu M, Su J, Ma Z, Jin M, Qiao W, Zhang Y, Feng Y, An N, Hou Y, Yang S, Chuan S, Lei Z. Cloning and expression patterns of neuromedin U and its receptors in pigs. Neuropeptides. 2017 Aug;64:47-60. doi: 10.1016/j.npep.2017.04.003. Epub 2017 Apr 6. PMID: 28434792. 4: Wang X, Feng Z, Li C, Cai X, Long H, Zhang X, Huang A, Zeng Y, Ren W, Xie Z. Analysis of the Antioxidant Composition of Low Molecular Weight Metabolites from the Agarolytic Bacterium Alteromonas macleodii QZ9-9: Possibilities for High-Added Value Utilization of Macroalgae. Antioxidants (Basel). 2022 Oct 3;11(10):1977. doi: 10.3390/antiox11101977. PMID: 36290700; PMCID: PMC9598285. 5: Mijiti M, Mori R, Nakashima Y, Banno A, Ye Y, Takeuchi A, Matsuba S, Kiriyama K, Sutoh K, Nagaoka S. Protamine-derived peptide RPR (Arg-Pro-Arg) ameliorates oleic acid-induced lipogenesis via the PepT1 pathway in HepG2 cells. Biosci Biotechnol Biochem. 2023 Jan 24;87(2):197-207. doi: 10.1093/bbb/zbac197. PMID: 36521839. 6: Garde-García H, Redondo-González E, Maestro-de Las Casas M, Fernández-Pérez C, Moreno-Sierra J. Biomarkers and intermediate-high risk non-muscle invasive bladder cancer: a multivariate analysis of three different cellular pathways with pronostic implications. Clin Transl Oncol. 2021 Apr;23(4):840-845. doi: 10.1007/s12094-020-02476-7. Epub 2020 Aug 24. PMID: 32839927. 7: Mohammed Basabaeen AA, Abdelgader EA, Babekir EA, Abdelrahim SO, Eltayeb NH, Altayeb OA, Fadul EA, Sabo A, Ibrahim IK. TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population. Asian Pac J Cancer Prev. 2019 May 25;20(5):1579-1585. doi: 10.31557/APJCP.2019.20.5.1579. PMID: 31128065; PMCID: PMC6857868. 8: Jiang N, Pan J, Wang L, Duan YZ. No significant association between p53 codon 72 Arg/Pro polymorphism and risk of oral cancer. Tumour Biol. 2013 Feb;34(1):587-96. doi: 10.1007/s13277-012-0587-9. Epub 2012 Nov 29. PMID: 23192640. 9: Martínez-Lucas P, Moreno-Cuesta J, García-Olmo DC, Sánchez-Sánchez F, Escribano-Martínez J, del Pozo AC, Lizán-García M, García-Olmo D. Relationship between the Arg72Pro polymorphism of p53 and outcome for patients with traumatic brain injury. Intensive Care Med. 2005 Sep;31(9):1168-73. doi: 10.1007/s00134-005-2715-0. Epub 2005 Jul 9. PMID: 16007417. 10: Sidorowicz W, Canizaro PC, Bĕhal FJ. Kinin cleavage by human erythrocytes. Am J Hematol. 1984;17(4):383-91. doi: 10.1002/ajh.2830170408. PMID: 6437213. 11: Burov SV, Moskalenko IuE, Leko MV, Dorosh MIu, Panarin EF. [Derivatives of N-amidinoproline and their use in conventional and solid phase peptide synthesis]. Bioorg Khim. 2006 Nov-Dec;32(6):565-73. Russian. doi: 10.1134/s1068162006060021. PMID: 17180906. 12: Sidorowicz W, Szechiński J, Canizaro PC, Bĕhal FJ. Cleavage of the Arg1-Pro2 bond of bradykinin by a human lung peptidase: isolation, characterization, and inhibition by several beta-lactam antibiotics. Proc Soc Exp Biol Med. 1984 Apr;175(4):503-9. doi: 10.3181/00379727-175-41828. PMID: 6709646. 13: Lindner G, Grosse G. Morphologische Untersuchungen über die Wirkung von Substanz P-Teilsequenzen auf Nervengewebekulturen [Morphological studies of the effect of substance P partial sequences on nerve tissue culture]. Z Mikrosk Anat Forsch. 1983;97(1):65-74. German. PMID: 6195835. 14: Swanson AA, Davis RM, McDonald JK. The identification of prolyl endopeptidase in bovine lenses: a preliminary report. Curr Eye Res. 1984 Apr;3(4):659-61. doi: 10.3109/02713688409003068. PMID: 6370608.